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. 2022 Dec;45(10):1177-1183.
doi: 10.1016/j.jfo.2022.05.014. Epub 2022 Nov 7.

Association between transforming growth factors-β and matrix metalloproteinases in the aqueous humor and plasma in myopic patients

Y Yue  1 , D Che  2 , Y-W Hsiao  2 , J Zhou  2 , K Zhao  3
Affiliations

Association between transforming growth factors-β and matrix metalloproteinases in the aqueous humor and plasma in myopic patients

Y Yue et al. J Fr Ophtalmol. 2022 Dec.

Abstract

Purpose: To investigate the relationship between levels of transforming growth factor beta (TGF-beta), matrix metalloproteinase (MMP) and tissue inhibitors of MMP (TIMP) in the aqueous humor (AH) and plasma (PL) of myopic patients.

Methods: Aqueous humor and plasma were collected intraoperatively from 37 myopic patients with various axial lengths (AL) during ICL surgery. The concentrations of TGF-β1, TGF-β2, TGF-β3, MMP-1, MMP-2, MMP-7, MMP-9, MMP-10, TIMP-1, TIMP-2, TIMP-3 and TIMP-4 were measured using Luminex xMAP Technology kits (Milliplex xMAP kits). The association between TGFβ and MMP/TIMP levels were analyzed based on the Spearman's correlation test or Pearson's correlation test.

Results: There was a negative correlation between TGF-β1 and MMP-1, TIMP-2, TIMP-3 and TIMP-4 in the AH, and a positive correlation between TGF-β1 and MMP-1 in the PL. In the AH, levels of TGF-β2 were positively correlated with levels of TIMP-3 (r=0.441; P < 0.001). In the PL, levels of TGF-β2 also correlated positively with levels of TIMP-3 (r=0.427; P < 0.001)).

Conclusion: The level of TGF-β2 was the highest among TGF-βs in the AH. A consistent positive correlation between TGF-β2 and TIMP-3 was found both in the AH and PL, indicating that systemic levels of TGF-β2 and MMPs/TIMPs may also play a role in myopic progression.

Keywords: Aqueous humor; High myopia; Humeur aqueuse; Matrix metalloproteinase; Myopie forte; Métalloprotéinase matricielle; Plasma; TGF-β.

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