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. 2022 Oct 30;58(11):1561.
doi: 10.3390/medicina58111561.

Does Opuntia ficus-indica Juice Supplementation Improve Biochemical and Cardiovascular Response to a 6-Minute Walk Test in Type 2 Diabetic Patients?

Salma Abedelmalek  1   2 , Khouloud Aloui  3 , Nesrine Boussetta  3 , Bayan Alahmadi  2 , Mohamed Zouch  1   2 , Hamdi Chtourou  3   4 , Nizar Souissi  3
Affiliations

Does Opuntia ficus-indica Juice Supplementation Improve Biochemical and Cardiovascular Response to a 6-Minute Walk Test in Type 2 Diabetic Patients?

Salma Abedelmalek et al. Medicina (Kaunas). .

Abstract

Background and objectives: The purpose of this study was to evaluate the effect of Opuntia ficus-indica juice (OFIJ) on performance and biochemical and physiological responses to a 6 min walking test (6MWT) in diabetic patients. Materials and Methods: Twenty diabetic patients performed a 6MWT at 07:00 h. During each test session, they were asked to drink 70 mL/day of natural OFIJ or placebo (PLA) for 4 days. Results: the results showed that cardiovascular parameters increased significantly after the 6MWT under both conditions. While, cortisol, HbA1c, cholesterol total (CT), triglycerides (TG), as well as low-density lipoprotein (LDL) were not modified between without and with supplementation. Likewise, no significant variation in performance was observed for PLA and OFIJ (p > 0.05). The cardiovascular parameters (heart rate max (HRmax), diastolic blood pressure (DBP), and systolic blood pressure (SBP)), lipid profile (CT, TG, LDL, and high-density lipoprotein HDL), hormonal parameters (insulin and glucagon), HbA1c and lactate ([La]) did not present any significant modification either between PLA or OFIJ (p > 0.05). Muscle-damage markers (creatine kinase (CK) and lactate dehydrogenase (LDH)], cortisol, and liver parameters (i.e., oxidative stress marker, γGT, and total bilirubin) as well as glucose (GLC) were affected by supplementation (p < 0.05) before and after the 6MWT, but this change was significant only for OFIJ (p < 0.05). Conclusion: OFIJ had an antioxidant capacity, improved performance of the 6MWT, and reduced muscle-damage markers and glucose level in type 2 diabetic patients.

Keywords: 6MWT; OFIJ supplementation; biochemical parameters; diabetes; muscle damage.

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Conflict of interest statement

The authors report no conflict of interest. The authors alone are responsible for the content and writing of the article.

Figures

Figure 1
Figure 1
Flow-chart of participant recruitment.
Figure 2
Figure 2
6MWT [A] and RPE scores [B] (mean ± SD) without and with supplementation of PLA and OFIJ. ¥: significant difference compared with PLA (p < 0.05).
Figure 3
Figure 3
Cardiovascular parameters (mean ± SD; n = 20) recorded before and after the 6MWT without and with supplementation of PLA and OFIJ. £: significant difference compared to before the 6MWT (p < 0.05).
Figure 4
Figure 4
Lipid-profile parameters (mean ± SD; n = 20) recorded before and after the 6MWT during without and with supplementation of PLA and OFIJ. £: significant difference compared to before the 6MWT (p < 0.05).
Figure 5
Figure 5
Hormonal parameters (mean ± SD; n = 20) recorded before and after the 6MWT during without and with supplementation of PLA and OFIJ. £: significant difference compared to before the 6MWT (p < 0.05). ¥: significant difference compared to without supplementation (p < 0.05).
Figure 6
Figure 6
Muscle-damage markers (mean ± SD; n = 20) recorded before and after the 6MWT during without and with supplementation of PLA and OFIJ. £: significant difference compared to before the 6MWT (p < 0.05). ¥: significant difference compared to without supplementation (p < 0.05).
Figure 7
Figure 7
Hepatic parameters (mean ± SD; n = 20) recorded before and after the 6MWT during without and with supplementation of PLA and OFIJ. £: significant difference compared to before the 6MWT (p < 0.05). ¥: significant difference compared to without supplementation (p < 0.05).
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