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Review
. 2023 Jan 13;24(2):1566.
doi: 10.3390/ijms24021566.

Endoplasmic Reticulum Stress and Cancer: Could Unfolded Protein Response Be a Druggable Target for Cancer Therapy?

Gregorio Bonsignore  1 , Simona Martinotti  1 , Elia Ranzato  1
Affiliations
Review

Endoplasmic Reticulum Stress and Cancer: Could Unfolded Protein Response Be a Druggable Target for Cancer Therapy?

Gregorio Bonsignore et al. Int J Mol Sci. .

Abstract

Unfolded protein response (UPR) is an adaptive response which is used for re-establishing protein homeostasis, and it is triggered by endoplasmic reticulum (ER) stress. Specific ER proteins mediate UPR activation, after dissociation from chaperone Glucose-Regulated Protein 78 (GRP78). UPR can decrease ER stress, producing an ER adaptive response, block UPR if ER homeostasis is restored, or regulate apoptosis. Some tumour types are linked to ER protein folding machinery disturbance, highlighting how UPR plays a pivotal role in cancer cells to keep malignancy and drug resistance. In this review, we focus on some molecules that have been revealed to target ER stress demonstrating as UPR could be a new target in cancer treatment.

Keywords: ER stress; GRP78; UPR; natural compounds.

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Conflict of interest statement

The authors declare no conflict of interest.

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