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. 2023 Jan 11;15(2):370.
doi: 10.3390/nu15020370.

Interaction between SIDT2 and ABCA1 Variants with Nutrients on HDL-c Levels in Mexican Adults

Guadalupe León-Reyes  1 , Anna D Argoty-Pantoja  2 , Berenice Rivera-Paredez  2 , Alberto Hidalgo-Bravo  3 , Yvonne N Flores  4   5   6 , Jorge Salmerón  2 , Rafael Velázquez-Cruz  1
Affiliations

Interaction between SIDT2 and ABCA1 Variants with Nutrients on HDL-c Levels in Mexican Adults

Guadalupe León-Reyes et al. Nutrients. .

Abstract

Previous studies have reported that the SIDT2 and ABCA1 genes are involved in lipid metabolism. We aimed to analyze the association-the gene x gene interaction between rs17120425 and rs1784042 on SIDT2 and rs9282541 on ABCA1 and their diet interaction on the HDL-c serum levels-in a cohort of 1982 Mexican adults from the Health Workers Cohort Study. Demographic and clinical data were collected through a structured questionnaire and standardized procedures. Genotyping was performed using a predesigned TaqMan assay. The associations and interactions of interest were estimated using linear and logistic regression. Carriers of the rs17120425-A and rs1784042-A alleles had slightly higher blood HDL-c levels compared to the non-carriers. In contrast, rs9282541-A was associated with low blood HDL-c levels (OR = 1.34, p = 0.013). The rs1784042 x rs9282541 interaction was associated with high blood HDL-c levels (p = 3.4 × 10-4). Premenopausal women who carried at least one rs17120425-A allele and consumed high dietary fat, protein, monounsaturated, or polyunsaturated fatty acids levels had higher HDL-c levels than the non-carriers. These results support the association between the genetic variants on SIDT2 and ABCA1 with HDL-c levels and suggest gene-gene and gene-diet interactions over HDL-c concentrations in Mexican adults. Our findings could be a platform for developing clinical and dietary strategies for improving the health of the Mexican population.

Keywords: Mexican population; gene–diet interaction; gene–gene interaction; hypoalphalipoproteinemia; rs17120425; rs1784042; rs9282541.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Interactions between polymorphisms of SIDT2 and ABCA1 on HDL-c levels in the total population. (a) SIDT2–rs1784042 x ABCA1–rs9282541 and (b) SIDT2–rs17120425 x ABCA1–rs9282541 interactions on HDL-c levels. HDL-c showed as mean, 95% confidence interval. Models adjusted for age (years), sex, body mass index (Kg/m2), physical activity (inactive/active), lipid-lowering medications (no, yes), smoking (no, current, past), diabetes (no, impaired glucose tolerance, yes), and arterial hypertension (SBP ≥ 140 mm/Hg or DBP ≥ 90 mm/Hg or antihypertensive drug).
Figure 2
Figure 2
Interaction between SIDT2-rs17120425 and PUFAs dietary intake with HDL-c levels in premenopausal women. HDL-c showed as mean, 95% confidence interval. PUFAs intake plotted as the minimum and maximum consumptions in the study population. Model adjusted for age (years), body mass index (Kg/m2), physical activity (inactive/active), lipid-lowering medications (no, yes), smoking (no, current, past), diabetes (no, impaired glucose tolerance, yes), and arterial hypertension (SBP ≥ 140 or DBP ≥ 90 or antihypertensive drug); PUFAs: polyunsaturated fatty acids.
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