Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Jul 7;28(13):5283.
doi: 10.3390/molecules28135283.

Review Insights on Salivary Proteomics Biomarkers in Oral Cancer Detection and Diagnosis

Vidhya Rekha Umapathy  1 , Prabhu Manickam Natarajan  2 , Bhuminathan Swamikannu  3
Affiliations
Review

Review Insights on Salivary Proteomics Biomarkers in Oral Cancer Detection and Diagnosis

Vidhya Rekha Umapathy et al. Molecules. .

Abstract

Early detection is crucial for the treatment and prognosis of oral cancer, a potentially lethal condition. Tumor markers are abnormal biological byproducts produced by malignant cells that may be found and analyzed in a variety of bodily fluids, including saliva. Early detection and appropriate treatment can increase cure rates to 80-90% and considerably improve quality of life by reducing the need for costly, incapacitating medicines. Salivary diagnostics has drawn the interest of many researchers and has been proven to be an effective tool for both medication monitoring and the diagnosis of several systemic diseases. Since researchers are now searching for biomarkers in saliva, an accessible bodily fluid, for noninvasive diagnosis of oral cancer, measuring tumor markers in saliva is an interesting alternative to blood testing for early identification, post-treatment monitoring, and monitoring high-risk lesions. New molecular markers for oral cancer detection, treatment, and prognosis have been found as a result of developments in the fields of molecular biology and salivary proteomics. The numerous salivary tumor biomarkers and how they relate to oral cancer and pre-cancer are covered in this article. We are optimistic that salivary protein biomarkers may one day be discovered for the clinical detection of oral cancer because of the rapid advancement of proteomic technology.

Keywords: early detection; oral cancer; protein biomarkers; saliva; salivary proteomic.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Major list of proteins found in human saliva. Numbers in the chart represent the % of proteins in saliva.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Tabak L.A. A revolution in biomedical assessment: The development of salivary diagnostics. J. Dent. Educ. 2001;65:1335–1339. doi: 10.1002/j.0022-0337.2001.65.12.tb03492.x. - DOI - PubMed
    1. Chaubron F. Method of Evaluating Cancer Risk in Human (EP) No. 8,993,333. U.S. Patent. 2015 March 31;
    1. Malathi N., Mythili S., Vasanthi H.R. Salivary diagnostics: A brief review. ISRN Dent. 2014;2014:158786. doi: 10.1155/2014/158786. - DOI - PMC - PubMed
    1. Nunes L.A.S., Mussavira S., Bindhu O.S. Clinical and diagnostic utility of saliva as a non-invasive diagnostic fluid: A systematic review. Biochem. Med. 2015;25:177–192. doi: 10.11613/BM.2015.018. - DOI - PMC - PubMed
    1. Panta P., Venna V.R. Salivary RNA signatures in oral cancer detection. Anal. Cell. Pathol. 2014;2014:450629. doi: 10.1155/2014/450629. - DOI - PMC - PubMed

Grants and funding

This research received no external funding.
-