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Review
. 2024 Apr;61(4):2270-2282.
doi: 10.1007/s12035-023-03714-z. Epub 2023 Oct 23.

The Role of Astrocytic Mitochondria in the Pathogenesis of Brain Ischemia

Ling-Yan Zhang  1   2 , Yu-Yan Hu  1   2 , Xi-Yun Liu  1 , Xiao-Yu Wang  1 , Shi-Chao Li  1 , Jing-Ge Zhang  1   2 , Xiao-Hui Xian  1   2 , Wen-Bin Li  1   2 , Min Zhang  3   4
Affiliations
Review

The Role of Astrocytic Mitochondria in the Pathogenesis of Brain Ischemia

Ling-Yan Zhang et al. Mol Neurobiol. 2024 Apr.

Abstract

The morbidity rate of ischemic stroke is increasing annually with the growing aging population in China. Astrocytes are ubiquitous glial cells in the brain and play a crucial role in supporting neuronal function and metabolism. Increasing evidence shows that the impairment or loss of astrocytes contributes to neuronal dysfunction during cerebral ischemic injury. The mitochondrion is increasingly recognized as a key player in regulating astrocyte function. Changes in astrocytic mitochondrial function appear to be closely linked to the homeostasis imbalance defects in glutamate metabolism, Ca2+ regulation, fatty acid metabolism, reactive oxygen species, inflammation, and copper regulation. Here, we discuss the role of astrocytic mitochondria in the pathogenesis of brain ischemic injury and their potential as a therapeutic target.

Keywords: Astrocyte; Inflammation; Ischemic stroke; Mitochondria; Mitochondria transfer.

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