Gut microbiota in overweight and obesity: crosstalk with adipose tissue
- PMID: 38066102
- DOI: 10.1038/s41575-023-00867-z
Gut microbiota in overweight and obesity: crosstalk with adipose tissue
Abstract
Overweight and obesity are characterized by excessive fat mass accumulation produced when energy intake exceeds energy expenditure. One plausible way to control energy expenditure is to modulate thermogenic pathways in white adipose tissue (WAT) and/or brown adipose tissue (BAT). Among the different environmental factors capable of influencing host metabolism and energy balance, the gut microbiota is now considered a key player. Following pioneering studies showing that mice lacking gut microbes (that is, germ-free mice) or depleted of their gut microbiota (that is, using antibiotics) developed less adipose tissue, numerous studies have investigated the complex interactions existing between gut bacteria, some of their membrane components (that is, lipopolysaccharides), and their metabolites (that is, short-chain fatty acids, endocannabinoids, bile acids, aryl hydrocarbon receptor ligands and tryptophan derivatives) as well as their contribution to the browning and/or beiging of WAT and changes in BAT activity. In this Review, we discuss the general physiology of both WAT and BAT. Subsequently, we introduce how gut bacteria and different microbiota-derived metabolites, their receptors and signalling pathways can regulate the development of adipose tissue and its metabolic capacities. Finally, we describe the key challenges in moving from bench to bedside by presenting specific key examples.
© 2023. Springer Nature Limited.
Similar articles
-
The gut microbiota modulates both browning of white adipose tissue and the activity of brown adipose tissue.Rev Endocr Metab Disord. 2019 Dec;20(4):387-397. doi: 10.1007/s11154-019-09523-x. Rev Endocr Metab Disord. 2019. PMID: 31776853 Review.
-
Panax notoginseng saponins modulate the gut microbiota to promote thermogenesis and beige adipocyte reconstruction via leptin-mediated AMPKα/STAT3 signaling in diet-induced obesity.Theranostics. 2020 Sep 14;10(24):11302-11323. doi: 10.7150/thno.47746. eCollection 2020. Theranostics. 2020. PMID: 33042284 Free PMC article.
-
n-3 polyunsaturated fatty acids in the regulation of adipose tissue browning and thermogenesis in obesity: Potential relationship with gut microbiota.Prostaglandins Leukot Essent Fatty Acids. 2022 Feb;177:102388. doi: 10.1016/j.plefa.2021.102388. Epub 2021 Dec 29. Prostaglandins Leukot Essent Fatty Acids. 2022. PMID: 34995899 Review.
-
Functional changes of the gastric bypass microbiota reactivate thermogenic adipose tissue and systemic glucose control via intestinal FXR-TGR5 crosstalk in diet-induced obesity.Microbiome. 2022 Jun 24;10(1):96. doi: 10.1186/s40168-022-01264-5. Microbiome. 2022. PMID: 35739571 Free PMC article.
-
Resveratrol enhances brown adipose tissue activity and white adipose tissue browning in part by regulating bile acid metabolism via gut microbiota remodeling.Int J Obes (Lond). 2020 Aug;44(8):1678-1690. doi: 10.1038/s41366-020-0566-y. Epub 2020 Mar 17. Int J Obes (Lond). 2020. PMID: 32203111
Cited by
-
Ageing, microbes and health.Microb Biotechnol. 2024 May;17(5):e14477. doi: 10.1111/1751-7915.14477. Microb Biotechnol. 2024. PMID: 38801344 Free PMC article. Review.
-
Exosomes in the pathogenesis and treatment of cancer-related cachexia.J Transl Med. 2024 Apr 30;22(1):408. doi: 10.1186/s12967-024-05201-y. J Transl Med. 2024. PMID: 38689293 Free PMC article. Review.
References
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical