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. 2024 Feb;132(2):24001.
doi: 10.1289/EHP14287. Epub 2024 Feb 6.

Marking Time: Epigenetic Aging May Partially Explain the Arsenic-Cardiovascular Disease Link

Silke Schmidt

Marking Time: Epigenetic Aging May Partially Explain the Arsenic-Cardiovascular Disease Link

Silke Schmidt. Environ Health Perspect. 2024 Feb.

Abstract

New epigenetic clocks point to DNA methylation as a mechanism in the well-known link between arsenic exposure and cardiovascular disease risk. The results validate the use of these clocks in Native American populations.

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Figures

Indigenous woman with short hair and serious expression is standing by a road in a desert landscape with red mesas in background
Graphical abstract
Indigenous woman with short hair and serious expression is standing by a road in a desert landscape with red mesas in background
Using data from the Strong Heart Study—which enrolled Native Americans in Arizona, Oklahoma, North Dakota, and South Dakota—researchers found that the link between arsenic exposure and cardiovascular disease could be partly explained by epigenetic changes that suggested faster physiological aging. Image: © iStock.com/grandriver.
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