Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Jan 26:15:1305886.
doi: 10.3389/fimmu.2024.1305886. eCollection 2024.

Research advances of Zanthoxylum bungeanum Maxim. polyphenols in inflammatory diseases

Jinxin Qi  1   2 , Zhaoping Pan  1   2 , Xiaoyun Wang  1   2 , Nan Zhang  3 , Gu He  1   2 , Xian Jiang  1   2
Affiliations
Review

Research advances of Zanthoxylum bungeanum Maxim. polyphenols in inflammatory diseases

Jinxin Qi et al. Front Immunol. .

Abstract

Zanthoxylum bungeanum Maxim., commonly known as Chinese prickly ash, is a well-known spice and traditional Chinese medicine ingredient with a rich history of use in treating inflammatory conditions. This review provides a comprehensive overview of the botanical classification, traditional applications, and anti-inflammatory effects of Z. bungeanum, with a specific focus on its polyphenolic components. These polyphenols have exhibited considerable promise, as evidenced by preclinical studies in animal models, suggesting their therapeutic potential in human inflammatory diseases such as ulcerative colitis, arthritis, asthma, chronic obstructive pulmonary disease, cardiovascular disease, and neurodegenerative conditions. This positions them as a promising class of natural compounds with the potential to enhance human well-being. However, further research is necessary to fully elucidate their mechanisms of action and develop safe and effective therapeutic applications.

Keywords: NF-κB; Zanthoxylum bungeanum Maxim.; inflammation; inflammatory disease; polyphenols.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Constituents of Z. bungeanum and their pharmacological effects.
Figure 2
Figure 2
Polyphenols identified in Z. bungeanum.
Figure 3
Figure 3
Molecule mechanism of polyphenols in Z. bungeanum and their anti-inflammatory effect.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Bautista DM, Sigal YM, Milstein AD, Garrison JL, Zorn JA, Tsuruda PR, et al. . Pungent agents from Szechuan peppers excite sensory neurons by inhibiting two-pore potassium channels. Nat Neurosci (2008) 11(7):772–9. doi: 10.1038/nn.2143 - DOI - PMC - PubMed
    1. Zhang M, Wang J, Zhu L, Li T, Jiang W, Zhou J, et al. . Zanthoxylum bungeanum maxim. (Rutaceae): A systematic review of its traditional uses, botany, phytochemistry, pharmacology, pharmacokinetics, and toxicology. Int J Mol Sci (2017) 18(10):2172. doi: 10.3390/ijms18102172 - DOI - PMC - PubMed
    1. Institute of Botany, Chinese Academy of Sciences . Flora of China. China: Institute of Botany Chinese Academy of Sciences; (2007-2019).
    1. Commission CP. Pharmacopoeia of the People’s Republic of China. China: China Medical Science Press; (2020).
    1. Institute of Botany, Chinese Academy of Sciences . Flora Reipublicae Popularis Sinicae. China: Institute of Botany Chinese Academy of Sciences; (2005-2019).

Publication types

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by grants from the National Natural Science Foundation of China (82273559 and 82073473), the 1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University (ZYJC21036), the Clinical Research Innovation Project, West China Hospital, Sichuan University (2019HXCX10) and Sichuan University-Zigong Special Fund for University-Local Science and Technology Cooperation (2021CDZG-21).
-