Cognitive Fitness: Harnessing the Strength of Exerkines for Aging and Metabolic Challenges

doi:10.3390/sports12020057

Review

. 2024 Feb 13;12(2):57.

doi: 10.3390/sports12020057.

Cognitive Fitness: Harnessing the Strength of Exerkines for Aging and Metabolic Challenges

Mona Saheli¹, Mandana Moshrefi², Masoumeh Baghalishahi¹, Amirhossein Mohkami³, Yaser Firouzi⁴, Katsuhiko Suzuki⁵, Kayvan Khoramipour⁶

Affiliations

¹ Department of Anatomical Sciences, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman 7616913555, Iran.
² Department of Physiology and Pharmacology, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman 7616913555, Iran.
³ Department of Exercise Physiology, Faculty of Sport Sciences, Hakim Sabzevari University, Sabzevar 9617976487, Iran.
⁴ Department of Exercise Physiology, Faculty of Sport Sciences, Shahid Bahonar University, Kerman 7616913439, Iran.
⁵ Faculty of Sport Sciences, Waseda University, Tokorozawa 359-1192, Japan.
⁶ Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman 7619813159, Iran.

PMID: 38393277
PMCID: PMC10891799
DOI: 10.3390/sports12020057

Review

Cognitive Fitness: Harnessing the Strength of Exerkines for Aging and Metabolic Challenges

Mona Saheli et al. Sports (Basel). 2024.

. 2024 Feb 13;12(2):57.

doi: 10.3390/sports12020057.

Authors

Mona Saheli¹, Mandana Moshrefi², Masoumeh Baghalishahi¹, Amirhossein Mohkami³, Yaser Firouzi⁴, Katsuhiko Suzuki⁵, Kayvan Khoramipour⁶

Affiliations

¹ Department of Anatomical Sciences, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman 7616913555, Iran.
² Department of Physiology and Pharmacology, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman 7616913555, Iran.
³ Department of Exercise Physiology, Faculty of Sport Sciences, Hakim Sabzevari University, Sabzevar 9617976487, Iran.
⁴ Department of Exercise Physiology, Faculty of Sport Sciences, Shahid Bahonar University, Kerman 7616913439, Iran.
⁵ Faculty of Sport Sciences, Waseda University, Tokorozawa 359-1192, Japan.
⁶ Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman 7619813159, Iran.

PMID: 38393277
PMCID: PMC10891799
DOI: 10.3390/sports12020057

Abstract

Addressing cognitive impairment (CI) represents a significant global challenge in health and social care. Evidence suggests that aging and metabolic disorders increase the risk of CI, yet promisingly, physical exercise has been identified as a potential ameliorative factor. Specifically, there is a growing understanding that exercise-induced cognitive improvement may be mediated by molecules known as exerkines. This review delves into the potential impact of aging and metabolic disorders on CI, elucidating the mechanisms through which various exerkines may bolster cognitive function in this context. Additionally, the discussion extends to the role of exerkines in facilitating stem cell mobilization, offering a potential avenue for improving cognitive impairment.

Keywords: cognition; elderlies; exerkines; metabolic disorders; stem cells.

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Conflict of interest statement

The authors declare no conflict of interest.

References

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This research was funded by Neuroscience Research Center, Kerman University of Medical Sciences.

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[1] Petersen R.C. Mild cognitive impairment. Contin. Lifelong Learn. Neurol. 2016;22:404. doi: 10.1212/CON.0000000000000313. - DOI - PMC - PubMed

[2] Petersen R.C. Mild cognitive impairment. Contin. Lifelong Learn. Neurol. 2016;22:404. doi: 10.1212/CON.0000000000000313. - DOI - PMC - PubMed

[3] Posner M.I. Attention in Cognitive Neuroscience: An Overview. The MIT Press; Cambridge, MA, USA: 1995.

[4] Posner M.I. Attention in Cognitive Neuroscience: An Overview. The MIT Press; Cambridge, MA, USA: 1995.

[5] Corbo I., Casagrande M. Higher-level executive functions in healthy elderly and mild cognitive impairment: A systematic review. J. Clin. Med. 2022;11:1204. doi: 10.3390/jcm11051204. - DOI - PMC - PubMed

[6] Corbo I., Casagrande M. Higher-level executive functions in healthy elderly and mild cognitive impairment: A systematic review. J. Clin. Med. 2022;11:1204. doi: 10.3390/jcm11051204. - DOI - PMC - PubMed

[7] Roark B., Mitchell M., Hosom J.-P., Hollingshead K., Kaye J. Spoken language derived measures for detecting mild cognitive impairment. IEEE Trans. Audio Speech Lang. Process. 2011;19:2081–2090. doi: 10.1109/TASL.2011.2112351. - DOI - PMC - PubMed

[8] Roark B., Mitchell M., Hosom J.-P., Hollingshead K., Kaye J. Spoken language derived measures for detecting mild cognitive impairment. IEEE Trans. Audio Speech Lang. Process. 2011;19:2081–2090. doi: 10.1109/TASL.2011.2112351. - DOI - PMC - PubMed

[9] Singleton E.H., Fieldhouse J.L., van’t Hooft J.J., Scarioni M., van Engelen M.P.E., Sikkes S.A., de Boer C., Bocancea D.I., van den Berg E., Scheltens P.A., et al. Social cognition deficits and biometric signatures in the behavioural variant of Alzheimer’s disease. Brain. 2023;146:2163–2174. doi: 10.1093/brain/awac382. - DOI - PMC - PubMed

[10] Singleton E.H., Fieldhouse J.L., van’t Hooft J.J., Scarioni M., van Engelen M.P.E., Sikkes S.A., de Boer C., Bocancea D.I., van den Berg E., Scheltens P.A., et al. Social cognition deficits and biometric signatures in the behavioural variant of Alzheimer’s disease. Brain. 2023;146:2163–2174. doi: 10.1093/brain/awac382. - DOI - PMC - PubMed

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Cognitive Fitness: Harnessing the Strength of Exerkines for Aging and Metabolic Challenges

Affiliations

Cognitive Fitness: Harnessing the Strength of Exerkines for Aging and Metabolic Challenges

Authors

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Abstract

Conflict of interest statement

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Abstract

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