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Review
. 2024 Mar 20;29(6):1373.
doi: 10.3390/molecules29061373.

Targeting Cancer Hallmarks with Epigallocatechin Gallate (EGCG): Mechanistic Basis and Therapeutic Targets

Wamidh H Talib  1 , Dima Awajan  2 , Abdelrahim Alqudah  3 , Razan Alsawwaf  2 , Raha Althunibat  2 , Mahmoud Abu AlRoos  2 , Ala'a Al Safadi  2 , Sharif Abu Asab  2 , Rawan W Hadi  1 , Lina T Al Kury  4
Affiliations
Review

Targeting Cancer Hallmarks with Epigallocatechin Gallate (EGCG): Mechanistic Basis and Therapeutic Targets

Wamidh H Talib et al. Molecules. .

Abstract

Epigallocatechin gallate (EGCG) is a catechin, which is a type of flavonoid found in high concentrations in green tea. EGCG has been studied extensively for its potential health benefits, particularly in cancer. EGCG has been found to exhibit anti-proliferative, anti-angiogenic, and pro-apoptotic effects in numerous cancer cell lines and animal models. EGCG has demonstrated the ability to interrupt various signaling pathways associated with cellular proliferation and division in different cancer types. EGCG anticancer activity is mediated by interfering with various cancer hallmarks. This article summarize and highlight the effects of EGCG on cancer hallmarks and focused on the impacts of EGCG on these cancer-related hallmarks. The studies discussed in this review enrich the understanding of EGCG's potential as a therapeutic tool against cancer, offering a substantial foundation for scientists and medical experts to advance scientific and clinical investigations regarding EGCG's possibility as a potential anticancer treatment.

Keywords: angiogenesis; anticancer; cancer hallmarks; epigallocatechin gallate (EGCG); immune evasion; metastasis.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 2
Figure 2
Green tea metabolism in human body [17].
Figure 1
Figure 1
Summary for the potential cancer hallmarks targets for EGCG. Generated by BioRender (https://www.biorender.com/, access date: 1 February 2024).
Figure 3
Figure 3
Hepatotoxicity of EGCG [37].
Figure 4
Figure 4
Structure of epigallocatechin-3-gallate. [(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl) chroman-3-yl]3,4,5-trihydroxy-benzoate.
Figure 5
Figure 5
Binding of EGCG induce lipid raft-mediated apoptosis [80].
Figure 6
Figure 6
EGCG induce apoptosis in cancer cells through targeting glucose metabolism [62].
See this image and copyright information in PMC

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Grants and funding

This research was funded by the Applied Science Private University, Amman, Jordan (grant number DRGS-2024-1).

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