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. 2024 Jun 5;16(22):28276-28289.
doi: 10.1021/acsami.4c06064. Epub 2024 May 24.

Effect of Microsphere Concentration on Catechin Release from Microneedle Arrays

Farzaneh Sabbagh  1 , Aarti R Deshmukh  1 , Yoseok Choi  1 , Beom Soo Kim  1
Affiliations

Effect of Microsphere Concentration on Catechin Release from Microneedle Arrays

Farzaneh Sabbagh et al. ACS Appl Mater Interfaces. .

Abstract

In this work, microspheres were developed by cross-linking glutaraldehyde in an aqueous gelatin solution with a surfactant and solvent. A poly(vinyl alcohol) (PVA) solution was produced and combined with catechin-loaded microspheres. Different microsphere concentrations (0%, 5%, 10%, and 15%) were applied to the PVA microneedles. The moisture content, particle size, swelling, and drug release percentage of microneedles were studied using various microsphere concentrations. Fourier transform infrared and scanning electron microscopy (SEM) investigations validated the structure of gelatin microspheres as well as their decoration in microneedles. The SEM scans revealed that spherical microspheres with a wrinkled and folded morphology were created, with no physical holes visible on the surface. The gelatin microspheres generated had a mean particle size of 20-30 μm. Ex vivo release analysis indicated that microneedles containing 10% microspheres released the most catechin, with 42.9% at 12 h and 84.4% at 24 h.

Keywords: Franz diffusion cells; gelatin microspheres; microneedles; polymeric carriers; transdermal drug delivery.

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