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. 2024 May 17;60(5):828.
doi: 10.3390/medicina60050828.

The Relationship between the Ewing Test, Sudoscan Cardiovascular Autonomic Neuropathy Score and Cardiovascular Risk Score Calculated with SCORE2-Diabetes

Andra-Elena Nica  1   2 , Emilia Rusu  1   2 , Carmen Dobjanschi  1   2 , Florin Rusu  3 , Claudia Sivu  1 , Oana Andreea Parlițeanu  4 , Gabriela Radulian  1
Affiliations

The Relationship between the Ewing Test, Sudoscan Cardiovascular Autonomic Neuropathy Score and Cardiovascular Risk Score Calculated with SCORE2-Diabetes

Andra-Elena Nica et al. Medicina (Kaunas). .

Abstract

Background and Objectives: Cardiac autonomic neuropathy (CAN) is a severe complication of diabetes mellitus (DM) strongly linked to a nearly five-fold higher risk of cardiovascular mortality. Patients with Type 2 Diabetes Mellitus (T2DM) are a significant cohort in which these assessments have particular relevance to the increased cardiovascular risk inherent in the condition. Materials and Methods: This study aimed to explore the subtle correlation between the Ewing test, Sudoscan-cardiovascular autonomic neuropathy score, and cardiovascular risk calculated using SCORE 2 Diabetes in individuals with T2DM. The methodology involved detailed assessments including Sudoscan tests to evaluate sudomotor function and various cardiovascular reflex tests (CART). The cohort consisted of 211 patients diagnosed with T2DM with overweight or obesity without established ASCVD, aged between 40 to 69 years. Results: The prevalence of CAN in our group was 67.2%. In the study group, according SCORE2-Diabetes, four patients (1.9%) were classified with moderate cardiovascular risk, thirty-five (16.6%) with high risk, and one hundred seventy-two (81.5%) with very high cardiovascular risk. Conclusions: On multiple linear regression, the SCORE2-Diabetes algorithm remained significantly associated with Sudoscan CAN-score and Sudoscan Nephro-score and Ewing test score. Testing for the diagnosis of CAN in very high-risk patients should be performed because approximately 70% of them associate CAN. Increased cardiovascular risk is associated with sudomotor damage and that Sudoscan is an effective and non-invasive measure of identifying such risk.

Keywords: CAN; CVDs; SCORE2-Diabetes; Sudoscan; T2DM.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
(a) Scatterplot showing the relationship between Sudoscan CAN-score on y-axis and SCORE 2—Diabetes on x-axis. (b) Scatterplot showing the relationship between Sudoscan Nephro-score on y-axis and SCORE 2—Diabetes on x-axis.
Figure 2
Figure 2
(a) Scatterplot showing the relationship between Sudoscan feets-score on y-axis and SCORE 2—Diabetes on x-axis. (b) Scatterplot showing the relationship between Sudoscan hands-score on y-axis and SCORE 2—Diabetes on x-axis.
Figure 3
Figure 3
ROC curve of Sudoscan-CAN score in detecting very high cardiovascular risk in patients with T2DM.
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Grants and funding

Publication of this paper was supported by the University of Medicine and Pharmacy Carol Davila, through the institutional program Publish not Perish.

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