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Randomized Controlled Trial
. 2024 May 7;16(10):1405.
doi: 10.3390/nu16101405.

Placebo Effect of Caffeine on Physiological Parameters and Physical Performance

David Ortiz-Sánchez  1 , Alfredo Bravo-Sánchez  1   2 , María Ramírez-delaCruz  1 , Pablo Abián  1   3 , Javier Abián-Vicén  1
Affiliations
Randomized Controlled Trial

Placebo Effect of Caffeine on Physiological Parameters and Physical Performance

David Ortiz-Sánchez et al. Nutrients. .

Abstract

This study aimed to analyse the placebo effect associated with a high dose of caffeine (9 mg/kg) on heart rate and its variability and on strength tests.

Methods: 18 participants experienced in strength training (19.7 ± 2.3 years; 72.2 ± 15.0 kg; 169.6 ± 9.0 cm) performed two days of trials (caffeine-informed/placebo-ingested (placebo) and non-ingested (control)). Firstly, heart rate and its variability were measured while participants lay down for 15 min. After that, bench press and squat tests were performed at 3 different loads (50%, 75% and 90% of 1RM). Perception of performance, effort and side effects were also evaluated.

Results: no differences were found in the vast majority of strength variables analysed. Resting heart rate decreased in the placebo trial (60.39 ± 10.18 bpm control vs. 57.56 ± 9.50 bpm placebo, p = 0.040), and mean RR increased (1020.1 ± 172.9 ms control vs. 1071.5 ± 185.7 ms placebo, p = 0.032). Heart rate variability and perception of performance and effort were similar between conditions (p > 0.05 in all cases). Side effects such as activeness and nervousness were reported while consuming the placebo.

Conclusions: the placebo effect did not modify performance in the majority of the strength test variables, HRV and perception of performance and effort. However, resting heart rate was reduced, mean RR increased, and some side effects appeared in the placebo trial.

Keywords: ergogenic aids; expectations; heart rate variability; side effects; strength.

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Conflict of interest statement

The authors declare no conflicts of interest.

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