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. 2024 Jun;26(3):93-95.
doi: 10.1089/cell.2024.0029.

Revitalizing the Aging Immune System Through Selective Stem Cell Targeting

Anna Konturek-Ciesla  1 , David Bryder  1
Affiliations

Revitalizing the Aging Immune System Through Selective Stem Cell Targeting

Anna Konturek-Ciesla et al. Cell Reprogram. 2024 Jun.

Abstract

The interplay between aging and immune system deterioration presents a formidable challenge to human health, especially in the context of a globally aging population. Aging is associated with a decline in the body's ability to combat infections and an increased risk of various diseases, underlining the importance of rejuvenating the immune system as a strategy for promoting healthier aging. In issue 628 of Nature (2024), Ross et al. present a compelling study that introduces a novel strategy for rejuvenating the aged immune system (Ross et al., 2024). By using antibodies to selectively eliminate "aberrant" hematopoietic stem cells (HSCs), this research opens new avenues for addressing age-related immune deterioration.

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