Interferon-induced proteins. Purification and characterization of a 15,000-dalton protein from human and bovine cells induced by interferon
- PMID: 6501319
Interferon-induced proteins. Purification and characterization of a 15,000-dalton protein from human and bovine cells induced by interferon
Abstract
Human interferons induce a protein of 15,000 daltons in human and bovine cells. This protein is located in the cytoplasm in a soluble form and is induced by concentrations of interferon which induce the antiviral state. Messenger RNA prepared from interferon-treated human and bovine cells contains a mRNA which yields on translation in vitro a protein similar in size to the 15-kDa protein induced by interferon in vivo. The human protein has been purified to homogeneity from interferon-treated human cells by ion-exchange chromatography and reverse-phase high-performance liquid chromatography. A comparison of the peptides generated by V8 protease from the human and bovine 15-kDa proteins reveals that the two proteins are similar but not identical.
Similar articles
-
Synthesis of interferon-inducible proteins is regulated differently by interferon-alpha and interferon-gamma.Virology. 1984 Apr 30;134(2):483-8. doi: 10.1016/0042-6822(84)90317-9. Virology. 1984. PMID: 6443593
-
Translation of mouse interferon mRNA in heterologous cells.Methods Enzymol. 1981;79(Pt B):99-103. doi: 10.1016/s0076-6879(81)79019-0. Methods Enzymol. 1981. PMID: 6173728 No abstract available.
-
Genetic engineering of human interferons from lymphoblastoid cells: I. Cloning of interferon species expressed in Sendai-induced Namalva cells.Adv Biotechnol Processes. 1985;4:1-23. Adv Biotechnol Processes. 1985. PMID: 2996569 Review. No abstract available.
-
Interferon induces a 15-kilodalton protein exhibiting marked homology to ubiquitin.J Biol Chem. 1987 Aug 15;262(23):11315-23. J Biol Chem. 1987. PMID: 2440890
-
Isolation of cDNA clones for the interferon-induced 67,000-dalton protein: direct induction of a family of mRNAs by human interferon-alpha and interferon-gamma.J Interferon Res. 1990 Jun;10(3):309-19. doi: 10.1089/jir.1990.10.309. J Interferon Res. 1990. PMID: 1696608
Cited by
-
UiO-66 nanoparticles combat influenza A virus in mice by activating the RIG-I-like receptor signaling pathway.J Nanobiotechnology. 2024 Mar 9;22(1):99. doi: 10.1186/s12951-024-02358-y. J Nanobiotechnology. 2024. PMID: 38461229 Free PMC article.
-
Unveiling the Multifaceted Roles of ISG15: From Immunomodulation to Therapeutic Frontiers.Vaccines (Basel). 2024 Feb 1;12(2):153. doi: 10.3390/vaccines12020153. Vaccines (Basel). 2024. PMID: 38400136 Free PMC article. Review.
-
ISG15 as a prognostic biomarker in solitary fibrous tumour.Cell Mol Life Sci. 2022 Jul 21;79(8):434. doi: 10.1007/s00018-022-04454-4. Cell Mol Life Sci. 2022. PMID: 35864381 Free PMC article.
-
ISG15 and ISGylation in Human Diseases.Cells. 2022 Feb 4;11(3):538. doi: 10.3390/cells11030538. Cells. 2022. PMID: 35159348 Free PMC article. Review.
-
Crosstalk Between SUMO and Ubiquitin-Like Proteins: Implication for Antiviral Defense.Front Cell Dev Biol. 2021 Apr 21;9:671067. doi: 10.3389/fcell.2021.671067. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 33968942 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources