Chronic toxicity and oncogenicity bioassay of inhaled ethylene in Fischer-344 rats
- PMID: 6745536
- DOI: 10.1016/0272-0590(84)90205-7
Chronic toxicity and oncogenicity bioassay of inhaled ethylene in Fischer-344 rats
Abstract
The toxicity and oncogenicity of inhaled ethylene was determined in Fischer-344 rats. Nine hundred and sixty animals were randomly divided into four groups of one hundred twenty animals of each sex and were exposed 6 hr/day, 5 days/week, for up to 24 months to concentrations of ethylene in air of 0, 300, 1000, or 3000 ppm. The maximum tolerated dose was not used as concentrations above 3000 ppm were considered hazardous because of the risks associated with ethylene's explosive properties. The calculated time-weighted average concentrations for the 24 months of exposure were 0.0, 301, 1003, and 3003 ppm, respectively. Randomly selected animals were necropsied and examined after 6, 12, and 18 months of exposure. All surviving rats were necropsied at 24 months. A complete selection of tissues and organs from all animals in the control and 3000-ppm groups were examined for microscopic lesions. All animals were examined for clinical changes throughout the course of the study and selected animals were used to determine ophthalmologic or hematologic effects and for clinical blood chemistry or urinalysis effects. There were 151 unscheduled deaths (15.7% of 960 animals). There was no difference in mortality between groups during the 2-year study. Gross examination of rats dying during the study, or of those that were sacrificed as scheduled, did not reveal any lesions attributable to ethylene exposure. Histologically, a variety of proliferative, degenerative, and inflammatory lesions were observed in both the control and 3000-ppm groups. These lesions were typical of those seen in this strain of animal and were considered unrelated to ethylene exposure.(ABSTRACT TRUNCATED AT 250 WORDS)
Similar articles
-
Chronic toxicity and oncogenicity bioassay of inhaled toluene in Fischer-344 rats.Fundam Appl Toxicol. 1983 Jul-Aug;3(4):315-9. doi: 10.1016/s0272-0590(83)80146-8. Fundam Appl Toxicol. 1983. PMID: 6628894
-
Carcinogenic and toxicologic effects of inhaled ethylene oxide and propylene oxide in F344 rats.Toxicol Appl Pharmacol. 1984 Oct;76(1):69-84. doi: 10.1016/0041-008x(84)90030-9. Toxicol Appl Pharmacol. 1984. PMID: 6484993
-
NTP technical report on the toxicity studies of Dibutyl Phthalate (CAS No. 84-74-2) Administered in Feed to F344/N Rats and B6C3F1 Mice.Toxic Rep Ser. 1995 Apr;30:1-G5. Toxic Rep Ser. 1995. PMID: 12209194
-
Toxicology and carcinogenesis studies of milk thistle extract (CAS No. 84604-20-6) in F344/N rats and B6C3F1 mice (Feed Studies).Natl Toxicol Program Tech Rep Ser. 2011 May;(565):1-177. Natl Toxicol Program Tech Rep Ser. 2011. PMID: 21685957 Review.
-
Ethylene.IARC Monogr Eval Carcinog Risks Hum. 1994;60:45-71. IARC Monogr Eval Carcinog Risks Hum. 1994. PMID: 7869580 Free PMC article. Review. No abstract available.
Cited by
-
The role of endogenous versus exogenous sources in the exposome of putative genotoxins and consequences for risk assessment.Arch Toxicol. 2022 May;96(5):1297-1352. doi: 10.1007/s00204-022-03242-0. Epub 2022 Mar 6. Arch Toxicol. 2022. PMID: 35249149 Free PMC article. Review.
-
Mode of action-based risk assessment of genotoxic carcinogens.Arch Toxicol. 2020 Jun;94(6):1787-1877. doi: 10.1007/s00204-020-02733-2. Epub 2020 Jun 15. Arch Toxicol. 2020. PMID: 32542409 Free PMC article. Review.
-
Ethylene oxide in blood of ethylene-exposed B6C3F1 mice, Fischer 344 rats, and humans.Toxicol Sci. 2013 Dec;136(2):344-58. doi: 10.1093/toxsci/kft218. Epub 2013 Sep 25. Toxicol Sci. 2013. PMID: 24068676 Free PMC article.
-
Kinetics of ethylene and ethylene oxide in subcellular fractions of lungs and livers of male B6C3F1 mice and male fischer 344 rats and of human livers.Toxicol Sci. 2011 Oct;123(2):384-98. doi: 10.1093/toxsci/kfr194. Epub 2011 Jul 23. Toxicol Sci. 2011. PMID: 21785163 Free PMC article.
-
Is ambient ethene a cancer risk factor?Environ Health Perspect. 1994 Oct;102 Suppl 4(Suppl 4):157-60. doi: 10.1289/ehp.102-1566931. Environ Health Perspect. 1994. PMID: 7821290 Free PMC article. Review.