Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1994 Feb 28;638(1-2):182-8.
doi: 10.1016/0006-8993(94)90648-3.

Collateral axonal projections to limbic structures from ventrolateral medullary A1 noradrenergic neurons

S Roder  1 , J Ciriello
Affiliations

Collateral axonal projections to limbic structures from ventrolateral medullary A1 noradrenergic neurons

S Roder et al. Brain Res. .

Abstract

Experiments were done to investigate whether catecholaminergic neurons within the ventrolateral medulla (VLM) send collateral axonal projections to the central nucleus of the amygdala (ACe) and the bed nucleus of the stria terminalis (BST). Unilateral microinjections of the fluorescent retrograde tracers fluorogold (FG) or rhodamine labelled latex micro-beads (Rd) were made into either ACe or BST in the rat. Brainstem sections were then processed immunohistochemically for the identification of cell bodies containing the catecholamine biosynthetic enzymes tyrosine hydroxylase, dopamine beta-hydroxylase (DBH) or phenylethanolamine-N-methyltransferase (PNMT). Retrogradely labelled cell bodies projecting to either ACe or BST were found throughout the rostrocaudal extent of VLM, bilaterally. Approximately 44% of these retrogradely labelled neurons were found to contain both retrograde tracers. In addition, approximately 91% of the VLM neurons that send collateral axonal projections to ACe and BST were also immunoreactive to DBH. None were found to contain PNMT immunoreactivity. These results demonstrate that noradrenergic neurons of the A1 cell group in VLM innervate ACe and BST via collateral axonal projections and suggest that these VLM neurons may be directly involved in relaying cardiovascular afferent and/or visceral afferent information directly to these limbic structures.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

LinkOut - more resources

-