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Comparative Study
. 1995 Oct 6;83(1):111-9.
doi: 10.1016/0092-8674(95)90239-2.

Complexins: cytosolic proteins that regulate SNAP receptor function

H T McMahon  1 , M Missler, C Li, T C Südhof
Affiliations
Free article
Comparative Study

Complexins: cytosolic proteins that regulate SNAP receptor function

H T McMahon et al. Cell. .
Free article

Abstract

A family of proteins called complexins was discovered that compete with alpha-SNAP, but not synaptotagmin, for SNAP receptor binding. Complexins I and II are highly homologous hydrophilic proteins that are tightly conserved, with 100% identity among mouse, rat, and human complexin II. They are enriched in neurons where they colocalize with syntaxin and SNAP-25; in addition, complexin II is expressed ubiquitously at low levels. Complexins bind weakly to syntaxin alone and not at all to synaptobrevin and SNAP-25, but strongly to the SNAP receptor-core complex composed of these three molecules. They compete with alpha-SNAP for binding to the core complex but not with other interacting molecules, including synaptotagmin I, suggesting that the complexins regulate the sequential interactions of alpha-SNAP and synaptotagmins with the SNAP receptor during exocytosis.

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