Canine model of obstructive sleep apnea: model description and preliminary application
- PMID: 8045863
- DOI: 10.1152/jappl.1994.76.4.1810
Canine model of obstructive sleep apnea: model description and preliminary application
Abstract
This report describes a canine model of obstructive sleep apnea (OSA) developed in our laboratory and the results of its preliminary short-term application. Healthy adult dogs were prepared with a tracheostomy and with implanted electroencephalographic and nuchal electromyographic recording electrodes. A silent occlusion valve was attached to the outer end of the endotracheal tube. The electroencephalogram and electromyogram were monitored continuously by a computer that determined sleep-wake state using software developed in our laboratory. At a predetermined time (e.g., 12 s) after each sleep onset, a signal was transmitted from the computer to the valve controller, resulting in airway occlusion. When the dog aroused from sleep, the occlusion was released. These events therefore mimic those that occur in human OSA. Successful operation of the model was confirmed during 5-day continuous trials in two dogs. During the trials, the dogs became increasingly somnolent both by behavioral observation and objective measurement. The frequency of occlusions increased, and measures of apnea severity, including apnea duration and end-apneic arterial oxygen saturation, worsened. We conclude that this experimental model of repeated airway occlusion during sleep provides a potentially powerful tool for investigating the sequelae of OSA.
Similar articles
-
Sleep architecture in a canine model of obstructive sleep apnea.Sleep. 1998 Dec 15;21(8):847-58. Sleep. 1998. PMID: 9871947
-
Effect of obstructive sleep apnea versus sleep fragmentation on responses to airway occlusion.Am J Respir Crit Care Med. 1997 May;155(5):1609-17. doi: 10.1164/ajrccm.155.5.9154865. Am J Respir Crit Care Med. 1997. PMID: 9154865
-
Sleep fragmentation in obstructive sleep apnea.Sleep. 1996 Nov;19(9 Suppl):S61-6. doi: 10.1093/sleep/19.suppl_9.s61. Sleep. 1996. PMID: 9122574 Review.
-
Effect of sleep deprivation on responses to airway obstruction in the sleeping dog.J Appl Physiol (1985). 1994 Oct;77(4):1811-8. doi: 10.1152/jappl.1994.77.4.1811. J Appl Physiol (1985). 1994. PMID: 7836204
-
Breathing abnormalities during sleep.Arch Intern Med. 1983 Jun;143(6):1221-8. Arch Intern Med. 1983. PMID: 6344828 Review.
Cited by
-
Hypoxia modeling techniques: A review.Heliyon. 2023 Feb;9(2):e13238. doi: 10.1016/j.heliyon.2023.e13238. Epub 2023 Jan 26. Heliyon. 2023. PMID: 36718422 Free PMC article. Review.
-
Metoprolol prevents neuronal dendrite remodeling in a canine model of chronic obstructive sleep apnea.Acta Pharmacol Sin. 2020 May;41(5):620-628. doi: 10.1038/s41401-019-0323-8. Epub 2019 Dec 20. Acta Pharmacol Sin. 2020. PMID: 31863057 Free PMC article.
-
Aortic remodelling induced by obstructive apneas is normalized with mesenchymal stem cells infusion.Sci Rep. 2019 Aug 7;9(1):11443. doi: 10.1038/s41598-019-47813-1. Sci Rep. 2019. PMID: 31391506 Free PMC article.
-
Establishment of a Rabbit Model of Chronic Obstructive Sleep Apnea and Application in Cardiovascular Consequences.Chin Med J (Engl). 2017 Feb 20;130(4):452-459. doi: 10.4103/0366-6999.199828. Chin Med J (Engl). 2017. PMID: 28218220 Free PMC article.
-
Chronic intermittent hypoxia and obstructive sleep apnea: an experimental and clinical approach.Hypoxia (Auckl). 2016 Apr 27;4:99-108. doi: 10.2147/HP.S103091. eCollection 2016. Hypoxia (Auckl). 2016. PMID: 27800512 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical