The spatio-temporal pattern of photoreceptor degeneration in the aged rd/rd mouse retina
- PMID: 8625386
- DOI: 10.1007/s004410050579
The spatio-temporal pattern of photoreceptor degeneration in the aged rd/rd mouse retina
Abstract
Photoreceptor degeneration in the retina of the rd/rd (retinal degeneration) mice has been studied using immunocytochemistry with antisera against cone- and rod-opsin. The rd/rd mice exhibited different regional specific rates of degeneration for rods and cones. As early as postnatal day 25, cells labelled with the rod-opsin and cone-opsin antisera disappeared preferently from the central retina. Whereas in the inferior half of the retina, degeneration subsequently proceeded towards the periphery, this did not occur in the dorsal hemisphere. By the age of 100 days, many cells immunoreactive for the cone-opsin antiserum and a few cells immunoreactive for the rod-opsin antiserum were located in an area of the dorsal retina. The ventral retina lacked labelled elements at this age. Finally, rd/rd mice at one year or 600 days of age contained a similar number of cone-opsin immunopositive cells (approximately 2000-2800 cells), occupying almost the same area in the retina as that found at 100 days of age. A photoreceptor candidate for the entrainment of non-visual photoreception probably remains in the cone population in aged rd/rd mice.
Similar articles
-
A 221-bp fragment of the mouse opsin promoter directs expression specifically to the rod photoreceptors of transgenic mice.Vis Neurosci. 1997 Jul-Aug;14(4):617-25. doi: 10.1017/s095252380001258x. Vis Neurosci. 1997. PMID: 9278991
-
Photoreceptors regulating circadian behavior: a mouse model.J Biol Rhythms. 1993;8 Suppl:S17-23. J Biol Rhythms. 1993. PMID: 8274758 Review.
-
Photopigments and circadian systems of vertebrates.Biophys Chem. 1995 Sep-Oct;56(1-2):3-11. doi: 10.1016/0301-4622(95)00009-m. Biophys Chem. 1995. PMID: 7662867 Review.
-
The persistence of cone photoreceptors within the dorsal retina of aged retinally degenerate mice (rd/rd): implications for circadian organization.Neurosci Lett. 1995 Feb 24;187(1):33-6. doi: 10.1016/0304-3940(95)11330-y. Neurosci Lett. 1995. PMID: 7617296
-
Circadian photoreception in the retinally degenerate mouse (rd/rd).J Comp Physiol A. 1991 Jul;169(1):39-50. doi: 10.1007/BF00198171. J Comp Physiol A. 1991. PMID: 1941717
Cited by
-
Loss of Müller cell glutamine synthetase immunoreactivity is associated with neuronal changes in late-stage retinal degeneration.Front Neuroanat. 2023 Mar 7;17:997722. doi: 10.3389/fnana.2023.997722. eCollection 2023. Front Neuroanat. 2023. PMID: 36960036 Free PMC article.
-
Retinoic acid signaling mediates peripheral cone photoreceptor survival in a mouse model of retina degeneration.Elife. 2022 Mar 22;11:e76389. doi: 10.7554/eLife.76389. Elife. 2022. PMID: 35315776 Free PMC article.
-
Intravitreal Delivery of Melatonin Is Protective Against the Photoreceptor Loss in Mice: A Potential Therapeutic Strategy for Degenerative Retinopathy.Front Pharmacol. 2020 Feb 12;10:1633. doi: 10.3389/fphar.2019.01633. eCollection 2019. Front Pharmacol. 2020. PMID: 32116667 Free PMC article.
-
Spatio-temporal characterization of S- and M/L-cone degeneration in the Rd1 mouse model of retinitis pigmentosa.BMC Neurosci. 2019 Sep 3;20(1):46. doi: 10.1186/s12868-019-0528-2. BMC Neurosci. 2019. PMID: 31481030 Free PMC article.
-
Visual responses in the dorsal lateral geniculate nucleus at early stages of retinal degeneration in rd1 PDE6β mice.J Neurophysiol. 2019 Oct 1;122(4):1753-1764. doi: 10.1152/jn.00231.2019. Epub 2019 Aug 28. J Neurophysiol. 2019. PMID: 31461375 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
Miscellaneous
