Synaptic depression and cortical gain control
- PMID: 8985017
- DOI: 10.1126/science.275.5297.221
Synaptic depression and cortical gain control
Abstract
Cortical neurons receive synaptic inputs from thousands of afferents that fire action potentials at rates ranging from less than 1 hertz to more than 200 hertz. Both the number of afferents and their large dynamic range can mask changes in the spatial and temporal pattern of synaptic activity, limiting the ability of a cortical neuron to respond to its inputs. Modeling work based on experimental measurements indicates that short-term depression of intracortical synapses provides a dynamic gain-control mechanism that allows equal percentage rate changes on rapidly and slowly firing afferents to produce equal postsynaptic responses. Unlike inhibitory and adaptive mechanisms that reduce responsiveness to all inputs, synaptic depression is input-specific, leading to a dramatic increase in the sensitivity of a neuron to subtle changes in the firing patterns of its afferents.
Comment in
-
Neuroscience. More than just frequency detectors?Science. 1997 Jan 10;275(5297):179-80. doi: 10.1126/science.275.5297.179. Science. 1997. PMID: 8999547 No abstract available.
Similar articles
-
Complementary Inhibitory Weight Profiles Emerge from Plasticity and Allow Flexible Switching of Receptive Fields.J Neurosci. 2020 Dec 9;40(50):9634-9649. doi: 10.1523/JNEUROSCI.0276-20.2020. Epub 2020 Nov 9. J Neurosci. 2020. PMID: 33168622 Free PMC article.
-
Asymmetric synaptic depression in cortical networks.Cereb Cortex. 2008 Apr;18(4):771-88. doi: 10.1093/cercor/bhm119. Epub 2007 Aug 9. Cereb Cortex. 2008. PMID: 17693394
-
Short-term synaptic plasticity as a temporal filter.Trends Neurosci. 2001 Jul;24(7):381-5. doi: 10.1016/s0166-2236(00)01835-x. Trends Neurosci. 2001. PMID: 11410267 Review.
-
Repetitive stimulation induced potentiation of excitatory transmission in the rat dorsal horn: an in vitro study.J Neurophysiol. 1994 Jan;71(1):216-28. doi: 10.1152/jn.1994.71.1.216. J Neurophysiol. 1994. PMID: 7908954
-
Cracking the neuronal code.Science. 1995 Nov 3;270(5237):756-7. doi: 10.1126/science.270.5237.756. Science. 1995. PMID: 7481761 Review. No abstract available.
Cited by
-
A Computational Model for the Simulation of Prepulse Inhibition and Its Modulation by Cortical and Subcortical Units.Brain Sci. 2024 May 15;14(5):502. doi: 10.3390/brainsci14050502. Brain Sci. 2024. PMID: 38790479 Free PMC article.
-
The spike-timing-dependent plasticity of VIP interneurons in motor cortex.Front Cell Neurosci. 2024 Apr 19;18:1389094. doi: 10.3389/fncel.2024.1389094. eCollection 2024. Front Cell Neurosci. 2024. PMID: 38706517 Free PMC article.
-
Role of Posterior Medial Thalamus in the Modulation of Striatal Circuitry and Choice Behavior.bioRxiv [Preprint]. 2024 Mar 27:2024.03.21.586152. doi: 10.1101/2024.03.21.586152. bioRxiv. 2024. PMID: 38585753 Free PMC article. Preprint.
-
Neural Circuitry Polarization in the Spinal Dorsal Horn (SDH): A Novel Form of Dysregulated Circuitry Plasticity during Pain Pathogenesis.Cells. 2024 Feb 25;13(5):398. doi: 10.3390/cells13050398. Cells. 2024. PMID: 38474361 Free PMC article. Review.
-
Functional dynamics and selectivity of two parallel corticocortical pathways from motor cortex to layer 5 circuits in somatosensory cortex.bioRxiv [Preprint]. 2024 May 20:2024.02.11.579810. doi: 10.1101/2024.02.11.579810. bioRxiv. 2024. Update in: eNeuro. 2024 Jun 21;11(6):ENEURO.0154-24.2024. doi: 10.1523/ENEURO.0154-24.2024. PMID: 38405888 Free PMC article. Updated. Preprint.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources