Dose-response relationship between prevalence of cerebrovascular disease and ingested inorganic arsenic
- PMID: 9303014
- DOI: 10.1161/01.str.28.9.1717
Dose-response relationship between prevalence of cerebrovascular disease and ingested inorganic arsenic
Abstract
Background and purpose: Circulatory diseases such as ischemic heart disease and peripheral vascular disease induced by long-term arsenic exposure have been well documented in previous studies, but the dose-response relationship between cerebrovascular disease and ingested inorganic arsenic remains to be elucidated. The prevalence of cerebrovascular disease among residents of the Lanyang Basin on the northeast coast of Taiwan was surveyed to examine its association with exposure to arsenic in well water.
Methods: A total of 8102 men and women from 3901 households were recruited in this study. The status of cerebrovascular disease of study subjects was identified through home-visit personal interviews and ascertained by review of hospital medical records according to the World Health Organization criteria. Information on consumption of well water, sociodemographic characteristics, cigarette smoking, and alcohol consumption habits, as well as personal and family history of diseases, was also obtained. Arsenic concentration in the well water of each household was determined by hydride generation and atomic absorption spectrometry. Logistic regression analysis was used to estimate multivariate-adjusted odds ratios and 95% confidence intervals for various risk factors of cerebrovascular disease.
Results: A significant dose-response relationship was observed between arsenic concentration in well water and prevalence of cerebrovascular disease after adjustment for age, sex, hypertension, diabetes mellitus, cigarette smoking, and alcohol consumption. The biological gradient was even more prominent for cerebral infarction, showing multivariate-adjusted odds ratios of 1.0, 3.4, 4.5, and 6.9, respectively, for those who consumed well water with an arsenic content of 0, 0.1 to 50.0, 50.1 to 299.9, and > 300 micrograms/L.
Conclusions: Long-term exposure to inorganic arsenic from well water was associated with an increased prevalence of cerebrovascular disease, especially cerebral infarction.
Similar articles
-
Biological gradient between long-term arsenic exposure and carotid atherosclerosis.Circulation. 2002 Apr 16;105(15):1804-9. doi: 10.1161/01.cir.0000015862.64816.b2. Circulation. 2002. PMID: 11956123
-
Dose-response relationship between peripheral vascular disease and ingested inorganic arsenic among residents in blackfoot disease endemic villages in Taiwan.Atherosclerosis. 1996 Feb;120(1-2):125-33. doi: 10.1016/0021-9150(95)05693-9. Atherosclerosis. 1996. PMID: 8645353
-
Ingested inorganic arsenic and prevalence of diabetes mellitus.Am J Epidemiol. 1994 Mar 1;139(5):484-92. doi: 10.1093/oxfordjournals.aje.a117031. Am J Epidemiol. 1994. PMID: 8154472
-
An overview on peripheral vascular disease in blackfoot disease-hyperendemic villages in Taiwan.Angiology. 2002 Sep-Oct;53(5):529-37. doi: 10.1177/000331970205300505. Angiology. 2002. PMID: 12365859 Review.
-
Chronic health effects in people exposed to arsenic via the drinking water: dose-response relationships in review.Toxicol Appl Pharmacol. 2004 Aug 1;198(3):243-52. doi: 10.1016/j.taap.2003.10.022. Toxicol Appl Pharmacol. 2004. PMID: 15276403 Review.
Cited by
-
Interaction landscape of a 'CαNN' motif with arsenate and arsenite: a potential peptide-based scavenger of arsenic.RSC Adv. 2019 Jan 9;9(2):1062-1074. doi: 10.1039/c8ra08225a. eCollection 2019 Jan 2. RSC Adv. 2019. PMID: 35517606 Free PMC article.
-
Relationship Analysis of Inorganic Arsenic Exposure and Metabolic Syndrome Based on Propensity Score Matching in Xinjiang, China.Diabetes Metab Syndr Obes. 2022 Mar 25;15:921-931. doi: 10.2147/DMSO.S349583. eCollection 2022. Diabetes Metab Syndr Obes. 2022. PMID: 35370411 Free PMC article.
-
Mechanism for Higher Tolerance to and Lower Accumulation of Arsenite in NtCyc07-Overexpressing Tobacco.Plants (Basel). 2020 Nov 3;9(11):1480. doi: 10.3390/plants9111480. Plants (Basel). 2020. PMID: 33153165 Free PMC article.
-
Association between Heavy Metals and Rare Earth Elements with Acute Ischemic Stroke: A Case-Control Study Conducted in the Canary Islands (Spain).Toxics. 2020 Sep 2;8(3):66. doi: 10.3390/toxics8030066. Toxics. 2020. PMID: 32887274 Free PMC article.
-
Long-term observational study on 6223 survivors of arsenic poisoning due to contaminated milk powder during infancy.Cancer Sci. 2020 Oct;111(10):3873-3880. doi: 10.1111/cas.14623. Epub 2020 Sep 5. Cancer Sci. 2020. PMID: 32885537 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical