Lipid peroxidation level and antioxidant micronutrient status in a pre-aging population; correlation with chronic disease prevalence in a French epidemiological study (Nantes, France)
- PMID: 9430087
Lipid peroxidation level and antioxidant micronutrient status in a pre-aging population; correlation with chronic disease prevalence in a French epidemiological study (Nantes, France)
Abstract
Objective: The general objective of the Etude du Viellissement Arterial (EVA) program is to follow vascular aging and the decline in cognitive functions at the cerebrovascular level longitudinally over a 4-year period. One of the specific objectives of this EVA study is to examine epidemiologically the relationship between the markers of oxidative stress (lipid peroxidation), the antioxidant micronutrient status (particularly of selenium, vitamin E, and the carotenoids) and the prevalence of chronic disorders occurring during the pre-aging period.
Methods: 1389 subjects aged from 59 to 71 years were studied.
Results: The concentration of plasma lipid peroxides was higher than in young adults (2.91 +/- 0.38, men; 2.97 +/- 0.40, women (mumol/l). On the other hand, plasma Se (1.09 +/- 0.21, men; 1.10 +/- 0.19, women (mumol/l)), erythrocyte vitamin E (5.32 +/- 1.29, men; 5.52 +/- 1.28, women (mumol/l)), and total plasma carotenoids (2.19 +/- 0.98, men; 3.07 +/- 1.33, women (mumol/l)) were comparable to values in young adults. In our cohort, 40% of subjects had unremarkable medical histories. The disorders most often encountered were lipemia (29.8% of men, 36.1% of women), and hypertension (28.9% of men, 30.4% of women).
Conclusion: Se and vitamin E levels were raised in cases of lipemia, especially in those treated with fibrates. The mechanism of the increase is unknown. In hypertensives and diabetics, there was a decrease in total carotenoids associated with increased peroxidative risk.
Similar articles
-
Selenium and cognitive impairment: a brief-review based on results from the EVA study.Biofactors. 2012 Mar-Apr;38(2):139-44. doi: 10.1002/biof.1003. Epub 2012 Mar 15. Biofactors. 2012. PMID: 22419540 Review.
-
Total plasma carotenoids and mortality in the elderly: results of the Epidemiology of Vascular Ageing (EVA) study.Br J Nutr. 2009 Jan;101(1):86-92. doi: 10.1017/S0007114508998445. Epub 2008 May 29. Br J Nutr. 2009. PMID: 18507882
-
Demographic and cardiovascular risk factors in relation to antioxidant status: the EVA Study.Int J Vitam Nutr Res. 1998;68(1):26-35. Int J Vitam Nutr Res. 1998. PMID: 9503045
-
Selenium and antioxidant vitamin and lipidoperoxidation levels in preaging French population. EVA Study Group. Edude de vieillissement artériel.Biol Trace Elem Res. 1997 May;57(2):183-90. doi: 10.1007/BF02778201. Biol Trace Elem Res. 1997. PMID: 9282265 Clinical Trial.
-
Increased risk of cardiovascular disease at suboptimal plasma concentrations of essential antioxidants: an epidemiological update with special attention to carotene and vitamin C.Am J Clin Nutr. 1993 May;57(5 Suppl):787S-797S. doi: 10.1093/ajcn/57.5.787S. Am J Clin Nutr. 1993. PMID: 8475897 Review.
Cited by
-
8-Isoprostane: A salivary oxidative stress biomarker for oral submucous fibrosis and oral squamous cell carcinoma.J Oral Maxillofac Pathol. 2020 May-Aug;24(2):279-284. doi: 10.4103/jomfp.JOMFP_235_19. Epub 2020 Sep 9. J Oral Maxillofac Pathol. 2020. PMID: 33456237 Free PMC article.
-
Is Extra Virgin Olive Oil an Ally for Women's and Men's Cardiovascular Health?Cardiovasc Ther. 2020 Apr 24;2020:6719301. doi: 10.1155/2020/6719301. eCollection 2020. Cardiovasc Ther. 2020. PMID: 32454893 Free PMC article. Review.
-
Serum Selenium and Lead Levels: a Possible Link with Diabetes and Associated Proteinuria.Biol Trace Elem Res. 2020 Feb;193(2):342-347. doi: 10.1007/s12011-019-01721-7. Epub 2019 Apr 19. Biol Trace Elem Res. 2020. PMID: 31004272
-
Selenium exposure and the risk of type 2 diabetes: a systematic review and meta-analysis.Eur J Epidemiol. 2018 Sep;33(9):789-810. doi: 10.1007/s10654-018-0422-8. Epub 2018 Jul 5. Eur J Epidemiol. 2018. PMID: 29974401 Review.
-
Supplementation of Micronutrient Selenium in Metabolic Diseases: Its Role as an Antioxidant.Oxid Med Cell Longev. 2017;2017:7478523. doi: 10.1155/2017/7478523. Epub 2017 Dec 26. Oxid Med Cell Longev. 2017. PMID: 29441149 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Medical