Effect of endurance training on mRNA expression of uncoupling proteins 1, 2, and 3 in the rat
- PMID: 9506477
- DOI: 10.1096/fasebj.12.3.335
Effect of endurance training on mRNA expression of uncoupling proteins 1, 2, and 3 in the rat
Abstract
Endurance exercise training has been shown to decrease diet-induced thermogenesis (DIT) in rats and humans. In rodents, most thermogenesis is thought to occur in brown adipose tissue via activation of the uncoupling protein-1 (UCP1) and in skeletal muscle. Since the level of UCP1 mRNA in rat BAT was reported to be unmodified by exercise training, the newly described uncoupling proteins UCP2 and UCP3 could be responsible for the decreased DIT in trained rats. UCP3 mRNA levels in endurance-trained rats were found to be reduced by 76% and 59% in tibialis anterior and soleus muscles, respectively. UCP2 mRNA levels were also decreased in tibialis anterior and in heart by 54% and 41%, respectively. Neither white adipose tissue UCP2 nor brown adipose tissue UCP1, UCP2, and UCP3 mRNA levels were modified. The results of this study show that a need for a higher metabolic efficiency is associated with decreased mRNA expression of the uncoupling proteins in skeletal and heart muscles, which would decrease energy dissipation in these tissues. The down-regulation of UCP3 and UCP2 expressions might also contribute to the rapid weight gain known to occur when exercise training ceased.
Similar articles
-
The role of uncoupling proteins in the regulation of metabolism.Acta Physiol Scand. 2003 Aug;178(4):405-12. doi: 10.1046/j.1365-201X.2003.01159.x. Acta Physiol Scand. 2003. PMID: 12864746 Review.
-
Regulation of UCP1, UCP2, and UCP3 mRNA expression in brown adipose tissue, white adipose tissue, and skeletal muscle in rats by estrogen.Biochem Biophys Res Commun. 2001 Oct 19;288(1):191-7. doi: 10.1006/bbrc.2001.5763. Biochem Biophys Res Commun. 2001. PMID: 11594772
-
Tissue-specific expression and cold-induced mRNA levels of uncoupling proteins in the Djungarian hamster.Physiol Biochem Zool. 2001 Mar-Apr;74(2):203-11. doi: 10.1086/319665. Physiol Biochem Zool. 2001. PMID: 11247739
-
Uncoupling protein-2 (UCP2) and uncoupling protein-3 (UCP3) expression in adipose tissue and skeletal muscle in humans.Int J Obes Relat Metab Disord. 1999 Jun;23 Suppl 6:S64-7. doi: 10.1038/sj.ijo.0800950. Int J Obes Relat Metab Disord. 1999. PMID: 10454128 Review.
-
Role of UCP homologues in skeletal muscles and brown adipose tissue: mediators of thermogenesis or regulators of lipids as fuel substrate?FASEB J. 1998 Jun;12(9):715-24. doi: 10.1096/fasebj.12.9.715. FASEB J. 1998. PMID: 9619450
Cited by
-
New Insights into Molecular Mechanisms Mediating Adaptation to Exercise; A Review Focusing on Mitochondrial Biogenesis, Mitochondrial Function, Mitophagy and Autophagy.Cells. 2021 Oct 2;10(10):2639. doi: 10.3390/cells10102639. Cells. 2021. PMID: 34685618 Free PMC article. Review.
-
Anti-obesity effect of Yangkyuksanwha-tang in high-fat diet-induced obese mice.BMC Complement Altern Med. 2019 Sep 5;19(1):246. doi: 10.1186/s12906-019-2669-3. BMC Complement Altern Med. 2019. PMID: 31488172 Free PMC article.
-
Chronic Exercise Improves Mitochondrial Function and Insulin Sensitivity in Brown Adipose Tissue.Front Physiol. 2018 Aug 17;9:1122. doi: 10.3389/fphys.2018.01122. eCollection 2018. Front Physiol. 2018. PMID: 30174613 Free PMC article.
-
Potential Causes of Elevated REE after High-Intensity Exercise.Med Sci Sports Exerc. 2017 Dec;49(12):2414-2421. doi: 10.1249/MSS.0000000000001386. Med Sci Sports Exerc. 2017. PMID: 28737531 Free PMC article.
-
High-intensity interval training and calorie restriction promote remodeling of glucose and lipid metabolism in diet-induced obesity.Am J Physiol Endocrinol Metab. 2017 Aug 1;313(2):E243-E256. doi: 10.1152/ajpendo.00445.2016. Epub 2017 Jun 6. Am J Physiol Endocrinol Metab. 2017. PMID: 28588097 Free PMC article.
Publication types
MeSH terms
Substances
Associated data
- Actions
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Research Materials