Implications of the hyperinsulinaemia-diabetes-cancer link for preventive efforts
- PMID: 9818771
Implications of the hyperinsulinaemia-diabetes-cancer link for preventive efforts
Abstract
Recent epidemiological evidence points to a link between non-insulin dependent diabetes mellitus type II (NIDDM) and cancer of the colon, liver, pancreas, breast and endometrium. This appears to be due to the long period of hyperinsulinaemia which precedes the clinical phase of NIDDM, insulin promoting colon tumour development as well as acting as a hepatocarcinogen. Indeed, the hormone could play a central role in neoplasia, and its influence could explain the observed enhancing effects of obesity and a high fat diet, as well as the inhibition associated with physical exercise, dehydroepiandrosterone administration and high soluble fibre intake. Measures to decrease insulin levels, including lifestyle improvement and supplementation with agents known to decrease insulin resistance may therefore offer a general approach to prevention of cancer in a wide variety of organ sites of major clinical importance.
Similar articles
-
Can endogenous hyperinsulinaemia explain the increased risk of cancer development and mortality in type 2 diabetes: evidence from mouse models.Diabetes Metab Res Rev. 2010 Nov;26(8):599-601. doi: 10.1002/dmrr.1139. Epub 2010 Oct 12. Diabetes Metab Res Rev. 2010. PMID: 20941806
-
[Diabetes, insulin, insulin analogues, and cancer].Dtsch Med Wochenschr. 2010 May;135(18):924-9. doi: 10.1055/s-0030-1253681. Epub 2010 Apr 27. Dtsch Med Wochenschr. 2010. PMID: 20425680 Review. German.
-
Diabetes mellitus type 2 - an independent risk factor for cancer?Exp Clin Endocrinol Diabetes. 2010 Jan;118(1):4-8. doi: 10.1055/s-0029-1243193. Epub 2010 Feb 1. Exp Clin Endocrinol Diabetes. 2010. PMID: 20127570 Review.
-
[Correlations of insulin resistance and neoplasms].Magy Onkol. 2006;50(2):127-35. Epub 2006 Aug 4. Magy Onkol. 2006. PMID: 16888676 Review. Hungarian.
-
Development and consequences of insulin resistance: lessons from animals with hyperinsulinaemia.Diabetes Metab. 1996 Apr;22(2):122-31. Diabetes Metab. 1996. PMID: 8792092 Review.
Cited by
-
A Review of Incidence and Related Risk Factors in the Development of Hepatocellular Carcinoma.Cureus. 2023 Nov 26;15(11):e49429. doi: 10.7759/cureus.49429. eCollection 2023 Nov. Cureus. 2023. PMID: 38149129 Free PMC article. Review.
-
Hepatocellular carcinoma in patients with renal dysfunction: Pathophysiology, prognosis, and treatment challenges.World J Gastroenterol. 2021 Jul 14;27(26):4104-4142. doi: 10.3748/wjg.v27.i26.4104. World J Gastroenterol. 2021. PMID: 34326614 Free PMC article. Review.
-
Thiazolidinediones, alpha-glucosidase inhibitors, meglitinides, sulfonylureas, and hepatocellular carcinoma risk: A meta-analysis.Metabolism. 2021 Jul;120:154780. doi: 10.1016/j.metabol.2021.154780. Epub 2021 Apr 21. Metabolism. 2021. PMID: 33891949 Free PMC article.
-
Risk factors for the development of hepatocellular carcinoma (HCC) in chronic hepatitis B virus (HBV) infection: a systematic review and meta-analysis.J Viral Hepat. 2021 Mar;28(3):493-507. doi: 10.1111/jvh.13452. Epub 2020 Dec 28. J Viral Hepat. 2021. PMID: 33305479 Free PMC article.
-
Association between type 2 diabetes and cancer incidence in China: data in hospitalized patients from 2006 to 2013.Ann Transl Med. 2020 Mar;8(5):176. doi: 10.21037/atm.2020.01.101. Ann Transl Med. 2020. PMID: 32309323 Free PMC article.