Nr2f1 (nuclear receptor subfamily 2 group F member 1) - Rat Genome Database

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Gene: Nr2f1 (nuclear receptor subfamily 2 group F member 1) Ictidomys tridecemlineatus
Analyze
Symbol: Nr2f1
Name: nuclear receptor subfamily 2 group F member 1
RGD ID: 12516068
Description: ENCODES a protein that exhibits retinoic acid-responsive element binding (ortholog); INVOLVED IN cerebral cortex regionalization (ortholog); forebrain development (ortholog); interneuron migration (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); Bosch-Boonstra-Schaaf optic atrophy syndrome (ortholog); Breast Neoplasms (ortholog); FOUND IN cytosol (inferred); nucleoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: COUP transcription factor 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213171,322,457 - 171,331,829 (-)NCBIHiC_Itri_2SpeTri2.0 EnsemblNW_0049365239,507,965 - 9,517,272 (-)EnsemblSpeTri2.0SpeTri2.0 EnsemblSpeTri2.0NW_0049365239,508,204 - 9,517,266 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Nr2f1Squirrelautism spectrum disorder  ISONR2F1 (Homo sapiens)8554872ClinVar Annotator: match by term: Autism spectrum disorderClinVarPMID:25741868
Nr2f1SquirrelBosch-Boonstra-Schaaf optic atrophy syndrome  ISONR2F1 (Homo sapiens)8554872ClinVar Annotator: match by term: Bosch-Boonstra-Schaaf optic atrophy syndromeClinVarPMID:18414213 more ...
Nr2f1SquirrelDevelopmental Disabilities  ISONR2F1 (Homo sapiens)8554872ClinVar Annotator: match by term: Global developmental delayClinVarPMID:25741868
Nr2f1Squirrelepilepsy  ISONR2F1 (Homo sapiens)8554872ClinVar Annotator: match by term: SeizureClinVar 
Nr2f1Squirrelfamilial adenomatous polyposis 1  ISONR2F1 (Homo sapiens)8554872ClinVar Annotator: match by term: Familial adenomatous polyposis 1ClinVarPMID:17963004 more ...
Nr2f1Squirrelgenetic disease  ISONR2F1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 more ...
Nr2f1SquirrelHereditary Neoplastic Syndromes  ISONR2F1 (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary cancer-predisposing syndromeClinVarPMID:17963004 more ...
Nr2f1SquirrelNeurodevelopmental Disorders  ISONR2F1 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868

Imported Disease Annotations - CTD

Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Nr2f1SquirrelBreast Neoplasms  ISONR2F1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:11850205
Nr2f1Squirrelovarian cyst  ISONR2F1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:21239663

Imported Disease Annotations - OMIM

Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)Nr2f1SquirrelBosch-Boonstra-Schaaf optic atrophy syndrome  ISONR2F1 (Homo sapiens)7240710 OMIM 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)Nr2f1Squirrelcell differentiation involved_inIEAPANTHER:PTN000638964 and PANTHER:PTN002786784150520179 TreeGrafterGO_REF:0000118Nr2f1Squirrelcerebral cortex regionalization acts_upstream_of_or_withinISOMGI:35217569068941 PMID:17828260MGIPMID:17828260Nr2f1Squirrelforebrain development acts_upstream_of_or_withinISONr2f1 (Mus musculus)9068941 PMID:15548577MGIPMID:15548577Nr2f1Squirrelinterneuron migration acts_upstream_of_or_withinISONr2f1 (Mus musculus)9068941 PMID:15548577MGIPMID:15548577Nr2f1Squirrelintracellular receptor signaling pathway involved_inIEAGO:0004879150520179 GOCGO_REF:0000108Nr2f1Squirrelnegative regulation of neuron projection development  ISONr2f1 (Rattus norvegicus)9068941 RGDPMID:7797489 and REF_RGD_ID:633499Nr2f1Squirrelnegative regulation of transcription by RNA polymerase II involved_inIEAPANTHER:PTN000638964 and PANTHER:PTN002786784150520179 TreeGrafterGO_REF:0000118Nr2f1Squirrelnegative regulation of transcription by RNA polymerase II acts_upstream_of_or_withinISONr2f1 (Mus musculus)9068941 PMID:7823919MGIPMID:7823919Nr2f1Squirrelnegative regulation of transcription by RNA polymerase II involved_inIEAUniProtKB:P10589 and ensembl:ENSP00000325819150520179 EnsemblGO_REF:0000107Nr2f1Squirrelnervous system development  ISONr2f1 (Rattus norvegicus)9068941 RGDPMID:7797489 and REF_RGD_ID:633499Nr2f1Squirrelneuron migration acts_upstream_of_or_withinISONr2f1 (Mus musculus)9068941 PMID:15548577MGIPMID:15548577Nr2f1Squirrelpositive regulation of miRNA transcription acts_upstream_of_or_withinISOMGI:23859309068941 PMID:24349493MGIPMID:24349493Nr2f1Squirrelpositive regulation of transcription by RNA polymerase II  ISONr2f1 (Rattus norvegicus)9068941 RGDPMID:7797489 and REF_RGD_ID:633499Nr2f1Squirrelpositive regulation of transcription by RNA polymerase II involved_inIEAPANTHER:PTN000638964 and PANTHER:PTN002786784150520179 TreeGrafterGO_REF:0000118Nr2f1Squirrelregulation of DNA-templated transcription involved_inIEAInterPro:IPR001628 and InterPro:IPR013088150520179 InterProGO_REF:0000002Nr2f1Squirrelregulation of gene expression acts_upstream_of_or_withinISOMGI:26768259068941 PMID:24349493MGIPMID:24349493

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)Nr2f1Squirrelcytosol located_inIEAUniProtKB:P10589 and ensembl:ENSP00000325819150520179 EnsemblGO_REF:0000107Nr2f1Squirrelnucleoplasm located_inIEAUniProtKB:P10589 and ensembl:ENSP00000325819150520179 EnsemblGO_REF:0000107Nr2f1Squirrelnucleus located_inIEAUniProtKB-SubCell:SL-0191150520179 UniProtGO_REF:0000044Nr2f1Squirrelnucleus located_inIEAUniProtKB-KW:KW-0539150520179 UniProtGO_REF:0000043Nr2f1Squirrelnucleus located_inIEAUniProtKB:P10589 and ensembl:ENSP00000325819150520179 EnsemblGO_REF:0000107

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)Nr2f1SquirrelDNA binding enablesIEAUniProtKB-KW:KW-0238150520179 UniProtGO_REF:0000043Nr2f1SquirrelDNA-binding transcription factor activity enablesIEAUniProtKB:P10589 and ensembl:ENSP00000325819150520179 EnsemblGO_REF:0000107Nr2f1SquirrelDNA-binding transcription factor activity enablesIEAInterPro:IPR001628150520179 InterProGO_REF:0000002Nr2f1SquirrelDNA-binding transcription repressor activity, RNA polymerase II-specific enablesIEAUniProtKB:P10589 and ensembl:ENSP00000325819150520179 EnsemblGO_REF:0000107Nr2f1Squirrelmetal ion binding enablesIEAUniProtKB-KW:KW-0479150520179 UniProtGO_REF:0000043Nr2f1Squirrelnuclear receptor activity enablesIEAPANTHER:PTN000638964 and PANTHER:PTN002786784150520179 TreeGrafterGO_REF:0000118Nr2f1Squirrelprotein binding enablesISOUniProtKB:Q004039068941 PMID:1517211UniProtPMID:1517211Nr2f1Squirrelprotein binding enablesISOUniProtKB:P613749068941 PMID:11043578BHF-UCLPMID:11043578Nr2f1Squirrelretinoic acid-responsive element binding  ISONr2f1 (Rattus norvegicus)9068941 RGDPMID:7797489 and REF_RGD_ID:633499Nr2f1SquirrelRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesIEAPANTHER:PTN000638964 and PANTHER:PTN002786784150520179 TreeGrafterGO_REF:0000118Nr2f1SquirrelRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesIEAUniProtKB:P10589 and ensembl:ENSP00000325819150520179 EnsemblGO_REF:0000107Nr2f1Squirrelsequence-specific DNA binding enablesIEAUniProtKB:P10589 and ensembl:ENSP00000325819150520179 EnsemblGO_REF:0000107Nr2f1Squirrelsequence-specific DNA binding enablesIEAInterPro:IPR001628150520179 InterProGO_REF:0000002Nr2f1Squirrelsequence-specific double-stranded DNA binding enablesIEAUniProtKB:P10589 and ensembl:ENSP00000325819150520179 EnsemblGO_REF:0000107Nr2f1Squirrelzinc ion binding enablesIEAInterPro:IPR001628 and InterPro:IPR013088150520179 InterProGO_REF:0000002

Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA)
nucleoplasm  (IEA)
nucleus  (IEA)

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Nr2f1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213171,322,457 - 171,331,829 (-)NCBIHiC_Itri_2SpeTri2.0 EnsemblNW_0049365239,507,965 - 9,517,272 (-)EnsemblSpeTri2.0SpeTri2.0 EnsemblSpeTri2.0NW_0049365239,508,204 - 9,517,266 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NR2F1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38593,583,222 - 93,594,611 (+)NCBIGRCh38GRCh38hg38GRCh38GRCh38.p14 Ensembl593,583,222 - 93,594,611 (+)EnsemblGRCh38hg38GRCh38GRCh37592,918,928 - 92,930,317 (+)NCBIGRCh37GRCh37hg19GRCh37Build 36592,944,799 - 92,955,544 (+)NCBINCBI36Build 36hg18NCBI36Build 34592,944,798 - 92,955,540NCBICelera588,778,440 - 88,789,186 (+)NCBICeleraCytogenetic Map5q15NCBIHuRef588,092,169 - 88,102,739 (+)NCBIHuRefCHM1_1592,351,749 - 92,362,489 (+)NCBICHM1_1T2T-CHM13v2.0594,067,283 - 94,078,673 (+)NCBIT2T-CHM13v2.0
Nr2f1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391378,337,090 - 78,346,954 (-)NCBIGRCm39GRCm39mm39GRCm39 Ensembl1378,337,092 - 78,347,876 (-)EnsemblGRCm39 EnsemblGRCm381378,188,971 - 78,198,873 (-)NCBIGRCm38GRCm38mm10GRCm38GRCm38.p6 Ensembl1378,188,973 - 78,199,757 (-)EnsemblGRCm38mm10GRCm38MGSCv371378,328,234 - 78,338,243 (-)NCBIGRCm37MGSCv37mm9NCBIm37MGSCv361378,652,524 - 78,662,420 (-)NCBIMGSCv36mm8Celera1380,475,542 - 80,485,460 (-)NCBICeleraCytogenetic Map13C1NCBIcM Map1341.38NCBI
Nr2f1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr829,776,179 - 9,785,924 (-)NCBIGRCr8mRatBN7.228,040,375 - 8,050,123 (-)NCBImRatBN7.2mRatBN7.2mRatBN7.2 Ensembl28,040,377 - 8,050,123 (-)EnsemblmRatBN7.2 EnsemblUTH_Rnor_SHR_Utx215,156,212 - 15,165,958 (-)NCBIRnor_SHRUTH_Rnor_SHR_UtxUTH_Rnor_SHRSP_BbbUtx_1.0213,255,522 - 13,265,268 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_WKY_Bbb_1.027,905,787 - 7,915,533 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0Rnor_6.025,569,954 - 5,579,894 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0Rnor_6.0 Ensembl25,569,935 - 5,579,894 (-)EnsemblRnor6.0rn6Rnor6.0Rnor_5.025,553,211 - 5,563,152 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0RGSC_v3.425,765,399 - 5,794,104 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4RGSC_v3.125,791,963 - 5,820,665 (-)NCBICelera24,489,100 - 4,498,590 (-)NCBICeleraCytogenetic Map2q11NCBI
Nr2f1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541818,614,995 - 18,624,584 (-)EnsemblChiLan1.0ChiLan1.0NW_00495541818,615,548 - 18,622,984 (-)NCBIChiLan1.0ChiLan1.0
NR2F1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2421,798,293 - 21,808,047 (-)NCBINHGRI_mPanPan1-v2NHGRI_mPanPan1519,951,902 - 19,964,301 (-)NCBINHGRI_mPanPan1Mhudiblu_PPA_v0521,773,283 - 21,785,746 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3PanPan1.1521,909,691 - 21,918,776 (-)NCBIpanpan1.1PanPan1.1panPan2PanPan1.1 Ensembl521,910,463 - 21,918,776 (-)Ensemblpanpan1.1panPan2
NR2F1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1315,707,198 - 15,716,875 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1CanFam3.1 Ensembl315,707,640 - 15,716,875 (-)EnsemblCanFam3.1canFam3CanFam3.1Dog10K_Boxer_Tasha317,056,142 - 17,065,912 (-)NCBIDog10K_Boxer_TashaROS_Cfam_1.0315,603,857 - 15,613,637 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0 Ensembl315,603,875 - 15,613,542 (-)EnsemblROS_Cfam_1.0 EnsemblUMICH_Zoey_3.1315,559,980 - 15,569,747 (-)NCBIUMICH_Zoey_3.1UNSW_CanFamBas_1.0315,546,214 - 15,555,980 (-)NCBIUNSW_CanFamBas_1.0UU_Cfam_GSD_1.0315,764,483 - 15,774,264 (-)NCBIUU_Cfam_GSD_1.0
NR2F1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2100,447,705 - 100,457,506 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1Sscrofa11.12100,447,661 - 100,457,510 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1Sscrofa10.22103,839,017 - 103,848,870 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NR2F1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1487,463,514 - 87,475,900 (+)NCBIChlSab1.1ChlSab1.1chlSab2ChlSab1.1 Ensembl487,466,249 - 87,475,112 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2Vero_WHO_p1.0NW_02366604936,657,859 - 36,670,290 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nr2f1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474312,478,832 - 12,488,458 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2HetGla 1.0NW_00462474312,479,427 - 12,488,178 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_013358981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040272104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040272105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010002273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSSTOT00000015398   ⟹   ENSSTOP00000013789
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365239,507,965 - 9,517,272 (-)Ensembl
RefSeq Acc Id: ENSSTOT00000036655   ⟹   ENSSTOP00000032029
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365239,508,703 - 9,515,425 (-)Ensembl
RefSeq Acc Id: XM_013358981   ⟹   XP_013214435
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213171,322,457 - 171,331,829 (-)NCBISpeTri2.0NW_0049365239,508,204 - 9,517,266 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040272104   ⟹   XP_040128038
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213171,322,457 - 171,329,737 (-)NCBI
RefSeq Acc Id: XM_040272105   ⟹   XP_040128039
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213171,322,457 - 171,329,973 (-)NCBI
Protein Sequences
Protein RefSeqs XP_013214435 (Get FASTA)   NCBI Sequence Viewer  
  XP_040128038 (Get FASTA)   NCBI Sequence Viewer  
  XP_040128039 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000013789.3
  ENSSTOP00000032029.1
GenBank Protein KAG3266366 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_013214435   ⟸   XM_013358981
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_040128039   ⟸   XM_040272105
- Peptide Label: isoform X3
- UniProtKB: A0A287DES0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040128038   ⟸   XM_040272104
- Peptide Label: isoform X1
RefSeq Acc Id: ENSSTOP00000032029   ⟸   ENSSTOT00000036655
RefSeq Acc Id: ENSSTOP00000013789   ⟸   ENSSTOT00000015398
Protein Domains
NR LBD   Nuclear receptor


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000015403 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000015398.3 UniProtKB/TrEMBL
  ENSSTOT00000036655.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.565.10 UniProtKB/TrEMBL
  3.30.50.10 UniProtKB/TrEMBL
InterPro NHR-like_dom_sf UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/TrEMBL
  Nuclear_hrmn_rcpt UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/TrEMBL
NCBI Gene Nr2f1 ENTREZGENE
PANTHER COUP TRANSCRIPTION FACTOR 1 UniProtKB/TrEMBL
  NUCLEAR HORMONE RECEPTOR UniProtKB/TrEMBL
Pfam Hormone_recep UniProtKB/TrEMBL
  zf-C4 UniProtKB/TrEMBL
PRINTS COUPTNFACTOR UniProtKB/TrEMBL
  STRDHORMONER UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/TrEMBL
SMART HOLI UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/TrEMBL
  SSF48508 UniProtKB/TrEMBL
UniProt A0A287DES0 ENTREZGENE, UniProtKB/TrEMBL
  I3MPN8_ICTTR UniProtKB/TrEMBL

 


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