Pparg (peroxisome proliferator activated receptor gamma) - Rat Genome Database

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Gene: Pparg (peroxisome proliferator activated receptor gamma) Chinchilla lanigera
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Symbol: Pparg
Name: peroxisome proliferator activated receptor gamma
RGD ID: 8779373
Description: ENCODES a protein that exhibits alpha-actinin binding (ortholog); arachidonic acid binding (ortholog); chromatin binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); BMP signaling pathway (ortholog); brown fat cell differentiation (ortholog); PARTICIPATES IN DNA modification pathway; Wnt signaling, non-canonical pathway; ASSOCIATED WITH abdominal obesity-metabolic syndrome (ortholog); acute kidney failure (ortholog); Acute Lung Injury (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); intracellular membrane-bounded organelle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: peroxisome proliferator-activated receptor gamma
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542914,873,908 - 14,937,387 (+)EnsemblChiLan1.0ChiLan1.0NW_00495542914,814,690 - 14,936,869 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
PpargChinchillaacute kidney failure treatmentISOPparg (Rattus norvegicus)9068941 RGDPMID:17494862 and REF_RGD_ID:8553020
PpargChinchillaAcute Lung Injury  ISOPparg (Rattus norvegicus)9068941protein:decreased expression:lung (rat)RGDPMID:16083301 and REF_RGD_ID:8553030
PpargChinchillaalcoholic cardiomyopathy  ISOPparg (Rattus norvegicus)9068941protein:increased expression:heart myocardiumRGDPMID:18783396 and REF_RGD_ID:2301868
PpargChinchillaAlveolar Bone Loss treatmentISOPparg (Rattus norvegicus)9068941associated with hypertension and periodontal diseaseRGDPMID:33364953 and REF_RGD_ID:329956421
PpargChinchillaAlzheimer's disease no_associationISOPPARG (Homo sapiens)9068941DNA:SNPs: :multiple (human)RGDPMID:18573313 and REF_RGD_ID:2301852
PpargChinchillaAlzheimer's disease susceptibilityISOPPARG (Homo sapiens)9068941DNA:SNP:cds:p.P12A(human)RGDPMID:17440948 and REF_RGD_ID:2311642
PpargChinchillaarteriosclerosis treatmentISOPparg (Rattus norvegicus)9068941 RGDPMID:15967870 and REF_RGD_ID:8553041
PpargChinchillaatherosclerosis  ISOPparg (Mus musculus)9068941protein:increased expression:aortic sinus and endothelium (mouse)RGDPMID:15779851 and REF_RGD_ID:8552894
PpargChinchillacardiovascular system disease susceptibilityISOPPARG (Homo sapiens)9068941associated with Diabetic Nephropathies more ...RGDPMID:18417957 and REF_RGD_ID:2301860
PpargChinchillacarotid artery disease  ISOPPARG (Homo sapiens)9068941 RGDPMID:15284449 and REF_RGD_ID:1580688
PpargChinchillaCarotid Artery Injuries treatmentISOPparg (Mus musculus)9068941mouse gene in a rat modelRGDPMID:19339015 and REF_RGD_ID:8553019
PpargChinchillaChemical and Drug Induced Liver Injury  ISOPparg (Mus musculus)9068941mRNA and protein:decreased expression:liverRGDPMID:26599535 and REF_RGD_ID:11554658
PpargChinchillaChronic Allograft Nephropathy  ISOPPARG (Homo sapiens)9068941protein:increased expression:kidney:RGDPMID:16221712 and REF_RGD_ID:13208600
PpargChinchillacognitive disorder susceptibilityISOPPARG (Homo sapiens)9068941associated with Diabetes Mellitus more ...RGDPMID:18639367 and REF_RGD_ID:2301850
PpargChinchillacolon cancer  ISOPPARG (Homo sapiens)9068941DNA:frameshift mutation:c.472delA (human)RGDPMID:10394368 and REF_RGD_ID:1601444
PpargChinchillacorneal neovascularization treatmentISOPparg (Mus musculus)9068941 RGDPMID:17625041 and REF_RGD_ID:8552895
PpargChinchillacoronary artery disease  ISOPPARG (Homo sapiens)9068941protein:decreased expression:carotid artery more ...RGDPMID:21709632 and REF_RGD_ID:8552814
PpargChinchillaCOVID-19  ISOPPARG (Homo sapiens)9068941mRNA:increased expression:peripheral blood mononuclear cell (human)RGDPMID:32228226 and REF_RGD_ID:28912744
PpargChinchilladiabetic encephalopathy treatmentISOPparg (Rattus norvegicus)9068941associated with Diabetes Mellitus and ExperimentalRGDPMID:24291733 and REF_RGD_ID:8553040
PpargChinchillaDiabetic Nephropathies  ISOPparg (Rattus norvegicus)9068941associated with Diabetes Mellitus and Non-Insulin-DependentRGDPMID:18388116 and REF_RGD_ID:2301862
PpargChinchillaDiabetic Nephropathies  ISOPparg (Mus musculus)9068941 RGDPMID:18780770 and REF_RGD_ID:2301845
PpargChinchilladiabetic retinopathy  ISOPparg (Mus musculus)9068941Retinal Leukostasis more ...RGDPMID:17003451 and REF_RGD_ID:8552824
PpargChinchillaend stage renal disease disease_progressionISOPPARG (Homo sapiens)9068941associated with Diabetes Mellitus more ...RGDPMID:18467141 and REF_RGD_ID:2301857
PpargChinchillaEndotoxemia  ISOPparg (Rattus norvegicus)9068941protein:increased expression:small intestine mucosa RGDPMID:21641970 and REF_RGD_ID:5135029
PpargChinchillaExperimental Autoimmune Myocarditis  ISOPparg (Rattus norvegicus)9068941protein:increased expression:myocardium (rat)RGDPMID:15167281 and REF_RGD_ID:8553039
PpargChinchillaExperimental Diabetes Mellitus  ISOPparg (Mus musculus)9068941protein:decreased expression:retinaRGDPMID:18806296 and REF_RGD_ID:2301844
PpargChinchillaExperimental Diabetes Mellitus  ISOPparg (Rattus norvegicus)9068941mRNA:altered expression:aorta more ...RGDPMID:18641696 and REF_RGD_ID:2301849
PpargChinchillaExperimental Liver Cirrhosis treatmentISOPparg (Rattus norvegicus)9068941 RGDPMID:22529699 and REF_RGD_ID:8553190
PpargChinchillaExperimental Liver Cirrhosis  ISOPparg (Rattus norvegicus)9068941 RGDPMID:18594976 and REF_RGD_ID:2301874
PpargChinchillaEye Burns  ISOPparg (Rattus norvegicus)9068941protein:increased expression:cornea more ...RGDPMID:24194635 and REF_RGD_ID:8552904
PpargChinchillaEye Injuries treatmentISOPparg (Mus musculus)9068941 RGDPMID:18658087 and REF_RGD_ID:8552893
PpargChinchillaFetal Growth Retardation  ISOPparg (Rattus norvegicus)9068941mRNA:decreased expression:lung (rat)RGDPMID:21425435 and REF_RGD_ID:8552971
PpargChinchillaFibrosis  ISOPparg (Rattus norvegicus)9068941associated with HypertensionRGDPMID:18360056 and REF_RGD_ID:2301893
PpargChinchillaFibrosis  ISOPparg (Mus musculus)9068941 RGDPMID:18511847 and REF_RGD_ID:2301856
PpargChinchillaglomerulosclerosis treatmentISOPparg (Rattus norvegicus)9068941 RGDPMID:11318962 and REF_RGD_ID:8553043
PpargChinchillaGraves ophthalmopathy  ISOPPARG (Homo sapiens)9068941mRNA:increased expression:orbital fat (human)RGDPMID:14588098 and REF_RGD_ID:8552818
PpargChinchillahepatocellular carcinoma severityISOPPARG (Homo sapiens)9068941protein:decreased expression:liverRGDPMID:27451128 and REF_RGD_ID:14694822
PpargChinchillahyperandrogenism  ISOPparg (Rattus norvegicus)9068941mRNA and protein:increased expression:ovary follicle (rat)RGDPMID:20813360 and REF_RGD_ID:8553031
PpargChinchillahypertension  ISOPparg (Rattus norvegicus)9068941protein:decreased expression:rostral ventrolateral medulla (rat)RGDPMID:20404217 and REF_RGD_ID:7175297
PpargChinchillahypertension  ISOPPARG (Homo sapiens)9068941human gene in a mouse modelRGDPMID:18316027 and REF_RGD_ID:2301864
PpargChinchillahypertension  ISOPparg (Rattus norvegicus)9068941 RGDPMID:15970297 more ...
PpargChinchillahypertension  ISOPPARG (Homo sapiens)9068941 RGDPMID:12923396 and REF_RGD_ID:1580690
PpargChinchillaInflammation  ISOPparg (Rattus norvegicus)9068941associated with Brain InjuriesRGDPMID:18479673 and REF_RGD_ID:2301881
PpargChinchillaInflammation  ISOPparg (Rattus norvegicus)9068941associated with Status EpilepticusRGDPMID:18455351 and REF_RGD_ID:2301886
PpargChinchillaInsulin Resistance  ISOPPARG (Homo sapiens)9068941DNA:nonsense mutationRGDPMID:12118251 and REF_RGD_ID:1601446
PpargChinchillaLeft Ventricular Hypertrophy  ISOPparg (Rattus norvegicus)9068941associated with HypertensionRGDPMID:18360056 and REF_RGD_ID:2301893
PpargChinchillaLymphatic Metastasis  ISOPPARG (Homo sapiens)9068941associated with Cholangiocarcinoma and protein:increased expression:bile duct epitheliumRGDPMID:20021832 and REF_RGD_ID:2317459
PpargChinchillaMetabolic Syndrome  ISOPPARG (Homo sapiens)9068941 RGDPMID:16186413 and REF_RGD_ID:1580686
PpargChinchillaMetabolic Syndrome amelioratesISOPparg (Mus musculus)9068941 RGDPMID:31353547 and REF_RGD_ID:401850595
PpargChinchillaMetabolic Syndrome no_associationISOPPARG (Homo sapiens)9068941DNA:SNP: :p.P12A (human)RGDPMID:18959602 and REF_RGD_ID:2301843
PpargChinchillaMetabolic Syndrome  ISOPparg (Rattus norvegicus)9068941 RGDPMID:16183630 and REF_RGD_ID:1580683
PpargChinchillaMyocardial Reperfusion Injury  ISOPparg (Mus musculus)9068941 RGDPMID:18562925 and REF_RGD_ID:2301853
PpargChinchillaobesity treatmentISOPparg (Rattus norvegicus)9068941 RGDPMID:30298849 and REF_RGD_ID:401960083
PpargChinchillaobesity susceptibilityISOPPARG (Homo sapiens)9068941DNA:polymorphismRGDPMID:18683148 and REF_RGD_ID:2301847
PpargChinchillaOxygen-Induced Retinopathy  ISOPparg (Mus musculus)9068941protein:decreased expression:retina (mouse)RGDPMID:18806296 and REF_RGD_ID:2301844
PpargChinchillaPain  ISOPparg (Rattus norvegicus)9068941 RGDPMID:18387855 and REF_RGD_ID:2301890
PpargChinchillapancreatic cancer susceptibilityISOPPARG (Homo sapiens)9068941DNA:polymorphism: :p.P12A (human)RGDPMID:19436234 and REF_RGD_ID:2317460
PpargChinchillapancreatic cancer  ISOPPARG (Homo sapiens)9068941 RGDPMID:19152448 and REF_RGD_ID:2317462
PpargChinchillapancreatic ductal carcinoma disease_progressionISOPPARG (Homo sapiens)9068941 RGDPMID:19396032 and REF_RGD_ID:2317461
PpargChinchillapancreatitis  ISOPparg (Rattus norvegicus)9068941 RGDPMID:18583255 and REF_RGD_ID:2301875
PpargChinchillaPerennial Allergic Rhinitis  ISOPPARG (Homo sapiens)9068941mRNA and protein:increased expression:nasal mucosa (human)RGDPMID:17116814 and REF_RGD_ID:8552811
PpargChinchillapolycystic kidney disease treatmentISOPparg (Rattus norvegicus)9068941 RGDPMID:21147840 and REF_RGD_ID:14701037
PpargChinchillapre-eclampsia  ISOPPARG (Homo sapiens)9068941 RGDPMID:15562025 and REF_RGD_ID:1580687
PpargChinchillaproliferative diabetic retinopathy susceptibilityISOPPARG (Homo sapiens)9068941DNA:snp:cds:p.P12A (rs1801282) (human)RGDPMID:23559865 and REF_RGD_ID:8552820
PpargChinchillaproliferative diabetic retinopathy onsetISOPPARG (Homo sapiens)9068941 RGDPMID:18541841 and REF_RGD_ID:2301854
PpargChinchillaproliferative diabetic retinopathy susceptibilityISOPPARG (Homo sapiens)9068941associated with Diabetes Mellitus more ...RGDPMID:19125195 and REF_RGD_ID:8699508
PpargChinchillasteatotic liver disease  ISOPparg (Rattus norvegicus)9068941 RGDPMID:15112352 and REF_RGD_ID:1580685
PpargChinchillasteatotic liver disease treatmentISOPparg (Rattus norvegicus)9068941 RGDPMID:30298849 and REF_RGD_ID:401960083
PpargChinchillatransient cerebral ischemia  ISOPparg (Rattus norvegicus)9068941 RGDPMID:18378216 more ...
PpargChinchillatype 2 diabetes mellitus susceptibilityISOPPARG (Homo sapiens)9068941DNA:polymorphism: :p.P12A (human)RGDPMID:18598350 and REF_RGD_ID:2301851
PpargChinchillatype 2 diabetes mellitus no_associationISOPPARG (Homo sapiens)9068941DNA:snp:cds:p.P12A (human)RGDPMID:9918859 and REF_RGD_ID:8552822
PpargChinchillaurinary bladder cancer  ISOPparg (Rattus norvegicus)9068941protein:decreased expression:urinary bladderRGDPMID:18712722 and REF_RGD_ID:2301870

Imported Disease Annotations - ClinVar

Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
PpargChinchillaCarotid Intimal Medial Thickness 1  ISOPPARG (Homo sapiens)8554872ClinVar Annotator: match by term: Carotid intimal medial thickness 1ClinVarPMID:25741868 and PMID:27749844
PpargChinchillacolon carcinoma  ISOPPARG (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10394368 and PMID:25741868
PpargChinchilladiabetes mellitus  ISOPPARG (Homo sapiens)8554872ClinVar Annotator: match by term: Monogenic diabetesClinVarPMID:19748282 more ...
PpargChinchillafamilial partial lipodystrophy  ISOPPARG (Homo sapiens)8554872ClinVar Annotator: match by term: Familial partial lipodystrophyClinVarPMID:21479595 more ...
PpargChinchillafamilial partial lipodystrophy type 3  ISOPPARG (Homo sapiens)8554872ClinVar Annotator: match by term: PPARG-related familial partial lipodystrophyClinVarPMID:10381354 more ...
PpargChinchillagenetic disease  ISOPPARG (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 and PMID:28492532
PpargChinchillaglioblastoma  ISOPPARG (Homo sapiens)8554872ClinVar Annotator: match by term: Glioblastoma and somaticClinVarPMID:10381354 more ...
PpargChinchillahigh grade glioma  ISOPPARG (Homo sapiens)8554872ClinVar Annotator: match by term: Glioma susceptibility 1ClinVarPMID:10381354 more ...
PpargChinchillalipodystrophy  ISOPPARG (Homo sapiens)8554872ClinVar Annotator: match by term: LipodystrophyClinVarPMID:10622252 more ...
PpargChinchillamaturity-onset diabetes of the young type 1  ISOPPARG (Homo sapiens)8554872ClinVar Annotator: match by term: Type 2 diabetes mellitusClinVar 
PpargChinchillamorbid obesity  ISOPPARG (Homo sapiens)8554872ClinVar Annotator: match by term: Morbid obesityClinVarPMID:10690291 more ...
PpargChinchillaobesity  ISOPPARG (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10381354 more ...
PpargChinchillaobesity  ISOPPARG (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10381354 more ...
PpargChinchillatype 2 diabetes mellitus  ISOPPARG (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10381354 more ...
PpargChinchillatype 2 diabetes mellitus  ISOPPARG (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10381354 more ...

Imported Disease Annotations - CTD

Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)PpargChinchillaacute kidney failure  ISOPPARG (Homo sapiens)9068941CTD more ...CTDPMID:20623750 more ...PpargChinchillaAcute Lung Injury  ISOPPARG (Homo sapiens)9068941CTD Direct Evidence: therapeuticCTDPMID:21153920PpargChinchillaacute promyelocytic leukemia  ISOPPARG (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:32929351PpargChinchillaadenocarcinoma  ISOPPARG (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:11034103PpargChinchillaAlzheimer's disease  ISOPPARG (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:15993441 more ...PpargChinchillaantiphospholipid syndrome  ISOPPARG (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:28182703PpargChinchillaatherosclerosis  ISOPPARG (Homo sapiens)9068941CTD Direct Evidence: therapeuticCTDPMID:18269830PpargChinchillaautosomal dominant polycystic kidney disease  ISOPPARG (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:20210794PpargChinchillaBarrett's esophagus  ISOPPARG (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:15387324PpargChinchillaChronobiology Disorders  ISOPPARG (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:22899986PpargChinchillaColonic Neoplasms  ISOPPARG (Homo sapiens)9068941CTD Direct Evidence: therapeuticCTDPMID:20540935PpargChinchillaColorectal Neoplasms  ISOPPARG (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:16489531PpargChinchillacongestive heart failure  ISOPPARG (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:26670611PpargChinchillaCrohn's disease  ISOPPARG (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:21829567PpargChinchillaDiabetic Nephropathies  ISOPPARG (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:28182703PpargChinchilladisease of metabolism  ISOPPARG (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:19589179PpargChinchillaDyslipidemias  ISOPPARG (Homo sapiens)9068941CTD Direct Evidence: therapeuticCTDPMID:16168052PpargChinchillaExperimental Diabetes Mellitus  ISOPPARG (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:12967931 more ...PpargChinchillaFollicular Thyroid Cancer  ISOPPARG (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:15785241PpargChinchillaglomerulonephritis  ISOPPARG (Homo sapiens)9068941CTD Direct Evidence: therapeuticCTDPMID:11318962PpargChinchillahepatocellular carcinoma  ISOPPARG (Homo sapiens)9068941CTD Direct Evidence: therapeuticCTDPMID:16374840PpargChinchillahypertension  ISOPPARG (Homo sapiens)9068941CTD more ...CTDPMID:15199296 more ...PpargChinchillaInflammation  ISOPPARG (Homo sapiens)9068941CTD more ...CTDPMID:19926821 and PMID:21354099PpargChinchillaInsulin Resistance  ISOPPARG (Homo sapiens)9068941CTD Direct Evidence: therapeuticCTDPMID:16168052 more ...PpargChinchillaischemia  ISOPPARG (Homo sapiens)9068941CTD Direct Evidence: therapeuticCTDPMID:12468449 and PMID:24433871PpargChinchillakidney failure  ISOPPARG (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:28182703PpargChinchillaleukostasis  ISOPPARG (Homo sapiens)9068941CTD Direct Evidence: therapeuticCTDPMID:12468449PpargChinchillalipid storage disease  ISOPPARG (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:21123845PpargChinchillaLiver Neoplasms  ISOPPARG (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:20143881PpargChinchillamelanoma  ISOPPARG (Homo sapiens)9068941CTD more ...CTDPMID:14512786 and PMID:28962521PpargChinchillametabolic dysfunction-associated steatotic liver disease  ISOPPARG (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:35654975PpargChinchillaNerve Degeneration  ISOPPARG (Homo sapiens)9068941CTD Direct Evidence: therapeuticCTDPMID:18289512PpargChinchillaosteoarthritis  ISOPPARG (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:17568789PpargChinchillapancreatic cancer  ISOPPARG (Homo sapiens)9068941CTD more ...CTDPMID:11034103 and PMID:11741176PpargChinchillapituitary-dependent Cushing's disease  ISOPPARG (Homo sapiens)9068941CTD Direct Evidence: therapeuticCTDPMID:16809932PpargChinchillapre-eclampsia  ISOPPARG (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:34995009PpargChinchillapsoriasis  ISOPPARG (Homo sapiens)9068941CTD Direct Evidence: therapeuticCTDPMID:10815854PpargChinchillaReperfusion Injury  ISOPPARG (Homo sapiens)9068941CTD Direct Evidence: therapeuticCTDPMID:12468449 more ...PpargChinchillaStomach Neoplasms  ISOPPARG (Homo sapiens)9068941CTD more ...CTDPMID:15492468 and PMID:19140230PpargChinchillaSubarachnoid Hemorrhage  ISOPPARG (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:29162556PpargChinchillaT-cell non-Hodgkin lymphoma  ISOPPARG (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:17255338PpargChinchillaThyroid Neoplasms  ISOPPARG (Homo sapiens)9068941CTD Direct Evidence: therapeuticCTDPMID:15785241

Imported Disease Annotations - MGI

Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)PpargChinchillaabdominal obesity-metabolic syndrome  ISOPparg (Mus musculus)9068941 MouseDO PpargChinchillacongenital generalized lipodystrophy type 2  ISOPparg (Mus musculus)9068941OMIM:269700MouseDO PpargChinchillaprimary pulmonary hypertension  ISOPparg (Mus musculus)9068941OMIM:178600 more ...MouseDO PpargChinchillasystemic lupus erythematosus  ISOPparg (Mus musculus)9068941OMIM:152700 more ...MouseDO 

Imported Disease Annotations - OMIM

Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)PpargChinchillaCarotid Intimal Medial Thickness 1  ISOPPARG (Homo sapiens)7240710 OMIM PpargChinchillafamilial partial lipodystrophy type 3  ISOPPARG (Homo sapiens)7240710 OMIM PpargChinchillaobesity  ISOPPARG (Homo sapiens)7240710 OMIM PpargChinchillatype 2 diabetes mellitus  ISOPPARG (Homo sapiens)7240710 OMIM 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)PpargChinchillaanimal organ regeneration  ISOPparg (Rattus norvegicus)9068941 RGDPMID:18565023 and REF_RGD_ID:2301877PpargChinchillaBMP signaling pathway involved_inISOUniProtKB:P126439068941 PMID:18382765BHF-UCLPMID:18382765PpargChinchillabrown fat cell differentiation acts_upstream_of_or_withinISOPparg (Mus musculus)9068941 PMID:18492766MGIPMID:18492766PpargChinchillacell fate commitment acts_upstream_of_or_withinISOMGI:26516059068941 PMID:24703703MGIPMID:24703703PpargChinchillacell fate commitment acts_upstream_of_or_withinISOMGI:1027849068941 PMID:15687259MGIPMID:15687259PpargChinchillacell maturation involved_inISOPPARG (Homo sapiens)9068941 PMID:9568716BHF-UCLPMID:9568716PpargChinchillacell population proliferation acts_upstream_ofISOMGI:23843219068941 PMID:12370429MGIPMID:12370429PpargChinchillacellular response to hyperoxia  ISOPparg (Rattus norvegicus)9068941 RGDPMID:22444276 and REF_RGD_ID:8553189PpargChinchillacellular response to hypoxia involved_inISOPparg (Rattus norvegicus)9068941PMID:29695452BHF-UCLPMID:29695452 and REF_RGD_ID:150521636PpargChinchillacellular response to insulin stimulus involved_inISOPPARG (Homo sapiens)9068941 PMID:10622252BHF-UCLPMID:10622252PpargChinchillacellular response to insulin stimulus acts_upstream_of_or_withinISOPparg (Mus musculus)9068941 PMID:26629404MGIPMID:26629404PpargChinchillacellular response to lithium ion acts_upstream_of_or_withinISOPparg (Mus musculus)9068941 PMID:15673614MGIPMID:15673614PpargChinchillacellular response to low-density lipoprotein particle stimulus involved_inISOPPARG (Homo sapiens)9068941 PMID:9568716BHF-UCLPMID:9568716PpargChinchillacellular response to organic cyclic compound acts_upstream_of_or_withinISOPparg (Mus musculus)9068941 PMID:12055200MGIPMID:12055200PpargChinchillacellular response to platelet-derived growth factor stimulus involved_inISOPparg (Mus musculus)9068941 MGI:5462034 and PMID:21880694BHF-UCLMGI:5462034 and PMID:21880694PpargChinchillacellular response to prostaglandin E stimulus  ISOPparg (Rattus norvegicus)9068941 RGDPMID:10797535 and REF_RGD_ID:8553016PpargChinchillacellular response to prostaglandin stimulus  ISOPparg (Rattus norvegicus)906894115-deoxy-delta12 and 14-prostaglandin J2RGDPMID:11936221 and REF_RGD_ID:8553042PpargChinchillacellular response to retinoic acid  ISOPparg (Rattus norvegicus)9068941 RGDPMID:10797535 and REF_RGD_ID:8553016PpargChinchillacellular response to vitamin E  ISOPparg (Rattus norvegicus)9068941 RGDPMID:11752099 and REF_RGD_ID:8553036PpargChinchillacold-induced thermogenesis acts_upstream_of_or_withinISOPparg (Mus musculus)9068941 PMID:30862682MGIPMID:30862682PpargChinchilladiet induced thermogenesis acts_upstream_of_or_withinISOMGI:26516059068941 PMID:24703703MGIPMID:24703703PpargChinchillaepithelial cell differentiation acts_upstream_of_or_withinISOMGI:1027849068941 PMID:15687259MGIPMID:15687259PpargChinchillaepithelial cell proliferation acts_upstream_ofISOMGI:23843219068941 PMID:12370429MGIPMID:12370429PpargChinchillafat cell differentiation acts_upstream_of_or_withinISOMGI:13370809068941 PMID:19066220MGIPMID:19066220PpargChinchillafat cell differentiation acts_upstream_of_or_withinISOMGI:19176499068941 PMID:16099986MGIPMID:16099986PpargChinchillafat cell differentiation acts_upstream_of_or_withinISOPR:Q6RI639068941 PMID:17595322MGIPMID:17595322PpargChinchillafat cell differentiation acts_upstream_of_or_withinISOPparg (Mus musculus)9068941 PMID:10937998 more ...MGIPMID:10937998 more ...PpargChinchillafat cell differentiation acts_upstream_of_or_withinISOPparg (Mus musculus)9068941 PMID:19066220 and PMID:22292086MGIPMID:19066220 and PMID:22292086PpargChinchillafatty acid oxidation  ISOPparg (Rattus norvegicus)9068941 RGDPMID:17003342 and REF_RGD_ID:1601464PpargChinchillaglucose homeostasis involved_inISOPPARG (Homo sapiens)9068941 PMID:10622252BHF-UCLPMID:10622252PpargChinchillaheart development  ISOPparg (Rattus norvegicus)9068941 RGDPMID:15754086 and REF_RGD_ID:1625767PpargChinchillalipoprotein transport involved_inISOPPARG (Homo sapiens)9068941 PMID:9568716BHF-UCLPMID:9568716PpargChinchillalong-chain fatty acid transport acts_upstream_of_or_withinISOPparg (Mus musculus)9068941 PMID:17463056MGIPMID:17463056PpargChinchillamacrophage derived foam cell differentiation involved_inISOPPARG (Homo sapiens)9068941 PMID:26504087UniProtPMID:26504087PpargChinchillamonocyte differentiation involved_inISOPPARG (Homo sapiens)9068941 PMID:9568716BHF-UCLPMID:9568716PpargChinchillamRNA transcription by RNA polymerase II involved_inISOPPARG (Homo sapiens)9068941 PMID:16373399ComplexPortalPMID:16373399PpargChinchillanegative regulation of acute inflammatory response  ISOPparg (Rattus norvegicus)9068941 RGDPMID:18479673 and REF_RGD_ID:2301881PpargChinchillanegative regulation of angiogenesis involved_inISOPPARG (Homo sapiens)9068941 PMID:28566713BHF-UCLPMID:28566713PpargChinchillanegative regulation of blood vessel endothelial cell migration involved_inISOPPARG (Homo sapiens)9068941 PMID:28566713BHF-UCLPMID:28566713PpargChinchillanegative regulation of BMP signaling pathway acts_upstream_of_or_withinISOPPARG (Homo sapiens)9068941 PMID:21743293ARUK-UCLPMID:21743293PpargChinchillanegative regulation of cardiac muscle hypertrophy in response to stress acts_upstream_of_or_withinISOPparg (Rattus norvegicus)9068941PMID:29695452BHF-UCLPMID:29695452 and REF_RGD_ID:150521636PpargChinchillanegative regulation of cell growth  ISOPparg (Rattus norvegicus)9068941 RGDPMID:18600431 and REF_RGD_ID:2301872PpargChinchillanegative regulation of cell population proliferation  ISOPparg (Rattus norvegicus)9068941 RGDPMID:16556873 more ...PpargChinchillanegative regulation of cellular response to insulin stimulus involved_inISOPparg (Mus musculus)9068941 MGI:5486574 and PMID:11387233BHF-UCLMGI:5486574 and PMID:11387233PpargChinchillanegative regulation of cellular response to transforming growth factor beta stimulus involved_inISOUniProtKB:P011379068941 PMID:28467929ARUK-UCLPMID:28467929PpargChinchillanegative regulation of cholesterol storage involved_inISOPPARG (Homo sapiens)9068941 PMID:19114110BHF-UCLPMID:19114110PpargChinchillanegative regulation of collagen biosynthetic process  ISOPparg (Rattus norvegicus)9068941 RGDPMID:16202214 and REF_RGD_ID:8553021PpargChinchillanegative regulation of connective tissue replacement involved in inflammatory response wound healing acts_upstream_of_or_withinISOPparg (Rattus norvegicus)9068941PMID:29695452BHF-UCLPMID:29695452 and REF_RGD_ID:150521636PpargChinchillanegative regulation of cytokine production involved_inISOPparg (Mus musculus)9068941 MGI:3799438 and PMID:18566389BHF-UCLMGI:3799438 and PMID:18566389PpargChinchillanegative regulation of DNA-templated transcription involved_inISOPparg (Mus musculus)9068941 MGI:3604169 and PMID:16127449BHF-UCLMGI:3604169 and PMID:16127449PpargChinchillanegative regulation of DNA-templated transcription acts_upstream_of_or_withinISOPparg (Mus musculus)9068941 PMID:15681609MGIPMID:15681609PpargChinchillanegative regulation of epithelial cell proliferation acts_upstream_of_or_withinISOMGI:23843219068941 PMID:12370429MGIPMID:12370429PpargChinchillanegative regulation of extracellular matrix assembly involved_inISOPPARG (Homo sapiens)9068941 PMID:25704091BHF-UCLPMID:25704091PpargChinchillanegative regulation of gene expression involved_inISOPPARG (Homo sapiens)9068941 PMID:28467929ARUK-UCLPMID:28467929PpargChinchillanegative regulation of gene expression involved_inISOPPARG (Sus scrofa)9068941 PMID:16530456AgBasePMID:16530456PpargChinchillanegative regulation of gene expression acts_upstream_ofISOUniProtKB:P312409068941PMID:28867608BHF-UCLPMID:28867608 and REF_RGD_ID:150521633PpargChinchillanegative regulation of gene expression involved_inISOUniProtKB:P312409068941PMID:28867608BHF-UCLPMID:28867608 and REF_RGD_ID:150521633PpargChinchillanegative regulation of gene expression involved_inISOUniProtKB:P011379068941 PMID:28467929ARUK-UCLPMID:28467929PpargChinchillanegative regulation of gene expression involved_inISOPparg (Mus musculus)9068941 MGI:6106785 and PMID:28467929ARUK-UCLMGI:6106785 and PMID:28467929PpargChinchillanegative regulation of gene expression acts_upstream_of_or_withinISOPparg (Mus musculus)9068941 MGI:5462034 and PMID:21880694BHF-UCLMGI:5462034 and PMID:21880694PpargChinchillanegative regulation of lipid storage involved_inISOPparg (Mus musculus)9068941 MGI:6155459 and PMID:29695452BHF-UCLMGI:6155459 and PMID:29695452PpargChinchillanegative regulation of lipid storage involved_inISOPparg (Rattus norvegicus)9068941PMID:29695452BHF-UCLPMID:29695452 and REF_RGD_ID:150521636PpargChinchillanegative regulation of macrophage derived foam cell differentiation involved_inISOPPARG (Homo sapiens)9068941 PMID:19114110BHF-UCLPMID:19114110PpargChinchillanegative regulation of MAPK cascade involved_inISOPPARG (Homo sapiens)9068941 PMID:18382765BHF-UCLPMID:18382765PpargChinchillanegative regulation of microglial cell activation involved_inISORNAcentral:URS000024A59E_100909068941 MGI:6270781 and PMID:30412727ARUK-UCLMGI:6270781 and PMID:30412727PpargChinchillanegative regulation of miRNA transcription acts_upstream_of_or_withinISOPPARG (Homo sapiens)9068941 PMID:24751522BHF-UCLPMID:24751522PpargChinchillanegative regulation of miRNA transcription involved_inISOPPARG (Homo sapiens)9068941 PMID:28522568BHF-UCLPMID:28522568PpargChinchillanegative regulation of mitochondrial fission involved_inISOPPARG (Homo sapiens)9068941 PMID:29182484BHF-UCLPMID:29182484PpargChinchillanegative regulation of neuroinflammatory response involved_inISORNAcentral:URS000024A59E_100909068941 MGI:6270781 and PMID:30412727ARUK-UCLMGI:6270781 and PMID:30412727PpargChinchillanegative regulation of osteoblast differentiation acts_upstream_ofISOPPARG (Homo sapiens)9068941 PMID:21042576 and PMID:21743293ARUK-UCLPMID:21042576 and PMID:21743293PpargChinchillanegative regulation of pancreatic stellate cell proliferation  ISOPparg (Rattus norvegicus)9068941 RGDPMID:16202214 and REF_RGD_ID:8553021PpargChinchillanegative regulation of peptide hormone secretion involved_inISOPparg (Mus musculus)9068941 MGI:5486574 and PMID:11387233BHF-UCLMGI:5486574 and PMID:11387233PpargChinchillanegative regulation of receptor signaling pathway via STAT acts_upstream_ofISOPPARG (Homo sapiens)9068941 PMID:28467929ARUK-UCLPMID:28467929PpargChinchillanegative regulation of sequestering of triglyceride involved_inISOPPARG (Homo sapiens)9068941 PMID:12700342BHF-UCLPMID:12700342PpargChinchillanegative regulation of SMAD protein signal transduction involved_inISOUniProtKB:P011379068941 PMID:28467929 and PMID:31023188BHF-UCLPMID:28467929 and PMID:31023188PpargChinchillanegative regulation of smooth muscle cell migration acts_upstream_ofISOPparg (Mus musculus)9068941 MGI:5462034 and PMID:21880694BHF-UCLMGI:5462034 and PMID:21880694PpargChinchillanegative regulation of smooth muscle cell proliferation acts_upstream_ofISOPPARG (Homo sapiens)9068941 PMID:18382765 more ...BHF-UCLPMID:18382765 more ...PpargChinchillanegative regulation of smooth muscle cell proliferation acts_upstream_ofISOUniProtKB:P312409068941PMID:28867608BHF-UCLPMID:28867608 and REF_RGD_ID:150521633PpargChinchillanegative regulation of smooth muscle cell proliferation acts_upstream_ofISOUniProtKB:P212749068941 MGI:3795340 and PMID:18382765ARUK-UCLMGI:3795340 and PMID:18382765PpargChinchillanegative regulation of smooth muscle cell proliferation acts_upstream_ofISOPparg (Mus musculus)9068941 MGI:5462034 and PMID:21880694BHF-UCLMGI:5462034 and PMID:21880694PpargChinchillanegative regulation of smooth muscle cell proliferation acts_upstream_ofISOUniProtKB:P011379068941 PMID:28467929ARUK-UCLPMID:28467929PpargChinchillanegative regulation of smooth muscle cell proliferation acts_upstream_ofISOPPARG (Homo sapiens)9068941 PMID:29182484BHF-UCLPMID:29182484PpargChinchillanegative regulation of telomerase activity  ISOPparg (Rattus norvegicus)9068941 RGDPMID:16556873 and REF_RGD_ID:1580657PpargChinchillanegative regulation of transcription by RNA polymerase II involved_inISOPparg (Mus musculus)9068941 MGI:3604169 and PMID:16127449BHF-UCLMGI:3604169 and PMID:16127449PpargChinchillanegative regulation of transcription by RNA polymerase II acts_upstream_of_or_withinISOMGI:961609068941 PMID:22207709MGIPMID:22207709PpargChinchillanegative regulation of transcription by RNA polymerase II acts_upstream_of_or_withinISOPparg (Mus musculus)9068941 PMID:8041794MGIPMID:8041794PpargChinchillanegative regulation of transcription by RNA polymerase II involved_inISOPPARG (Homo sapiens)9068941 PMID:12700342BHF-UCLPMID:12700342PpargChinchillanegative regulation of transforming growth factor beta receptor signaling pathway involved_inISOPPARG (Homo sapiens)9068941 PMID:31023188BHF-UCLPMID:31023188PpargChinchillanegative regulation of transforming growth factor beta receptor signaling pathway acts_upstream_of_or_withinISOUniProtKB:P01137 and UniProtKB:P126439068941 PMID:28467929ARUK-UCLPMID:28467929PpargChinchillanegative regulation of type II interferon-mediated signaling pathway involved_inISOPPARG (Homo sapiens)9068941 PMID:21268089BHF-UCLPMID:21268089PpargChinchillanegative regulation of vascular associated smooth muscle cell proliferation involved_inISOPPARG (Homo sapiens)9068941 PMID:24960162BHF-UCLPMID:24960162PpargChinchillanegative regulation of vascular associated smooth muscle cell proliferation involved_inISOPPARG (Homo sapiens)9068941 PMID:28522568BHF-UCLPMID:28522568PpargChinchillanegative regulation of vascular endothelial cell proliferation involved_inISOPPARG (Homo sapiens)9068941 PMID:24244514 and PMID:24960162BHF-UCLPMID:24244514 and PMID:24960162PpargChinchillaperoxisome proliferator activated receptor signaling pathway involved_inISOPPARG (Homo sapiens)9068941 PMID:20622039BHF-UCLPMID:20622039PpargChinchillaperoxisome proliferator activated receptor signaling pathway acts_upstream_of_or_withinISOPR:Q6RI639068941 PMID:17595322MGIPMID:17595322PpargChinchillaperoxisome proliferator activated receptor signaling pathway involved_inISOPPARG (Homo sapiens)9068941 PMID:25704091BHF-UCLPMID:25704091PpargChinchillaperoxisome proliferator activated receptor signaling pathway involved_inISOUniProtKB:P01137 and UniProtKB:P126439068941 PMID:28467929ARUK-UCLPMID:28467929PpargChinchillaplacenta development acts_upstream_of_or_withinISOPparg (Mus musculus)9068941 PMID:17463056MGIPMID:17463056PpargChinchillapositive regulation of adiponectin secretion acts_upstream_of_or_withinISOPparg (Rattus norvegicus)9068941PMID:29695452BHF-UCLPMID:29695452 and REF_RGD_ID:150521636PpargChinchillapositive regulation of adipose tissue development acts_upstream_ofISOPparg (Mus musculus)9068941 MGI:6508506 and PMID:25409310ARUK-UCLMGI:6508506 and PMID:25409310PpargChinchillapositive regulation of apoptotic process  ISOPparg (Rattus norvegicus)9068941 RGDPMID:16202214 and REF_RGD_ID:8553021PpargChinchillapositive regulation of apoptotic signaling pathway involved_inISOPPARG (Homo sapiens)9068941 PMID:18293083BHF-UCLPMID:18293083PpargChinchillapositive regulation of cholesterol efflux acts_upstream_ofISOPPARG (Homo sapiens)9068941 PMID:24751522BHF-UCLPMID:24751522PpargChinchillapositive regulation of cholesterol efflux involved_inISOPPARG (Sus scrofa)9068941 PMID:16530456AgBasePMID:16530456PpargChinchillapositive regulation of cholesterol transport acts_upstream_ofISOPPARG (Homo sapiens)9068941 PMID:17611579BHF-UCLPMID:17611579PpargChinchillapositive regulation of DNA-templated transcription involved_inISOPparg (Mus musculus)9068941 MGI:4881351 and PMID:21035761UniProtMGI:4881351 and PMID:21035761PpargChinchillapositive regulation of DNA-templated transcription acts_upstream_of_or_withinISOPparg (Mus musculus)9068941 PMID:14744933 and PMID:15684432MGIPMID:14744933 and PMID:15684432PpargChinchillapositive regulation of DNA-templated transcription involved_inISOPPARG (Sus scrofa)9068941 PMID:24287039AgBasePMID:24287039PpargChinchillapositive regulation of DNA-templated transcription involved_inISOUniProtKB:P197939068941 PMID:19043829CAFAPMID:19043829PpargChinchillapositive regulation of fat cell differentiation involved_inISOPparg (Rattus norvegicus)9068941PMID:27910957ARUK-UCLPMID:27910957 and REF_RGD_ID:38501075PpargChinchillapositive regulation of fat cell differentiation involved_inISOPparg (Mus musculus)9068941 MGI:4881351 and PMID:21035761UniProtMGI:4881351 and PMID:21035761PpargChinchillapositive regulation of fat cell differentiation involved_inISOPparg (Mus musculus)9068941 MGI:3846256 and PMID:19324970GO_CentralMGI:3846256 and PMID:19324970PpargChinchillapositive regulation of fatty acid oxidation  ISOPparg (Rattus norvegicus)9068941 RGDPMID:18475159 and REF_RGD_ID:2301882PpargChinchillapositive regulation of gene expression acts_upstream_of_or_withinISOPPARG (Homo sapiens)9068941 PMID:18382765BHF-UCLPMID:18382765PpargChinchillapositive regulation of gene expression involved_inISOPPARG (Homo sapiens)9068941 PMID:29182484BHF-UCLPMID:29182484PpargChinchillapositive regulation of gene expression acts_upstream_of_or_withinISOUniProtKB:P212749068941 MGI:3795340 and PMID:18382765BHF-UCLMGI:3795340 and PMID:18382765PpargChinchillapositive regulation of gene expression involved_inISOUniProtKB:Q91ZX79068941 MGI:6434720 and PMID:31023188BHF-UCLMGI:6434720 and PMID:31023188PpargChinchillapositive regulation of gene expression involved_inISOUniProtKB:P126439068941 PMID:28467929ARUK-UCLPMID:28467929PpargChinchillapositive regulation of intracellular cholesterol transport involved_inISOPPARG (Sus scrofa)9068941 PMID:16530456AgBasePMID:16530456PpargChinchillapositive regulation of miRNA transcription involved_inISOPPARG (Homo sapiens)9068941 PMID:25704091 and PMID:28566713BHF-UCLPMID:25704091 and PMID:28566713PpargChinchillapositive regulation of oligodendrocyte differentiation  ISOPparg (Rattus norvegicus)9068941 RGDPMID:18543250 and REF_RGD_ID:2301878PpargChinchillapositive regulation of phagocytosis, engulfment  ISOPparg (Rattus norvegicus)9068941 RGDPMID:15940641 and REF_RGD_ID:8553017PpargChinchillapositive regulation of prostaglandin biosynthetic process involved_inISOPPARG (Sus scrofa)9068941 PMID:24287039AgBasePMID:24287039PpargChinchillapositive regulation of protein secretion involved_inISOPPARG (Sus scrofa)9068941 PMID:16530456AgBasePMID:16530456PpargChinchillapositive regulation of SMAD protein signal transduction involved_inISOUniProtKB:Q91ZX79068941 MGI:6434720 and PMID:31023188BHF-UCLMGI:6434720 and PMID:31023188PpargChinchillapositive regulation of transcription by RNA polymerase II involved_inISOPPARG (Homo sapiens)9068941 PMID:20622039 and PMID:29182484BHF-UCLPMID:20622039 and PMID:29182484PpargChinchillapositive regulation of transcription by RNA polymerase II acts_upstream_of_or_withinISOPparg (Mus musculus)9068941 PMID:26427354 and PMID:30862682MGIPMID:26427354 and PMID:30862682PpargChinchillapositive regulation of transcription by RNA polymerase II acts_upstream_of_or_withinISOMGI:894332 and MGI:982149068941 PMID:23499423MGIPMID:23499423PpargChinchillapositive regulation of transcription by RNA polymerase II acts_upstream_of_or_withinISOPparg (Mus musculus)9068941 PMID:12037571 and PMID:16099986MGIPMID:12037571 and PMID:16099986PpargChinchillapositive regulation of transcription by RNA polymerase II involved_inISOPPARG (Sus scrofa)9068941 PMID:16239304UniProtPMID:16239304PpargChinchillapositive regulation of transcription by RNA polymerase II involved_inISOPparg (Mus musculus)9068941 MGI:3604169 more ...UniProtMGI:3604169 more ...PpargChinchillapositive regulation of transcription by RNA polymerase II involved_inISOPPARG (Homo sapiens)9068941 PMID:12700342 more ...BHF-UCLPMID:12700342 more ...PpargChinchillapositive regulation of transcription by RNA polymerase II involved_inISOPparg (Rattus norvegicus)9068941PMID:19383491BHF-UCLPMID:19383491 and REF_RGD_ID:8553457PpargChinchillapositive regulation of vascular associated smooth muscle cell apoptotic process involved_inISOPPARG (Homo sapiens)9068941 PMID:28522568BHF-UCLPMID:28522568PpargChinchillaregulation of blood pressure involved_inISOPPARG (Homo sapiens)9068941 PMID:10622252BHF-UCLPMID:10622252PpargChinchillaregulation of circadian rhythm involved_inISOPparg (Mus musculus)9068941 MGI:3830801 and PMID:19041764UniProtMGI:3830801 and PMID:19041764PpargChinchillaregulation of DNA-templated transcription involved_inISOPparg (Mus musculus)9068941 MGI:3830801 and PMID:19041764UniProtMGI:3830801 and PMID:19041764PpargChinchillaregulation of fat cell differentiation  ISOPparg (Rattus norvegicus)9068941 RGDPMID:10438514 and REF_RGD_ID:727277PpargChinchillaregulation of gene expression acts_upstream_of_or_withinISOMGI:26516059068941 PMID:24703703MGIPMID:24703703PpargChinchillaregulation of lipid metabolic process  ISOPparg (Rattus norvegicus)9068941 RGDPMID:18621767 and REF_RGD_ID:2301871PpargChinchillaregulation of protein localization to plasma membrane involved_inISOPPARG (Sus scrofa)9068941 PMID:16530456AgBasePMID:16530456PpargChinchillaregulation of transcription by RNA polymerase II acts_upstream_of_or_withinISOPparg (Mus musculus)9068941 PMID:26629404MGIPMID:26629404PpargChinchillaregulation of transcription by RNA polymerase II involved_inISOPparg (Mus musculus)9068941 MGI:3846256 and PMID:19324970GO_CentralMGI:3846256 and PMID:19324970PpargChinchillaregulation of transcription by RNA polymerase II  ISOPparg (Rattus norvegicus)9068941 RGDPMID:10438514 more ...PpargChinchillaresponse to caffeine  ISOPparg (Rattus norvegicus)9068941 RGDPMID:18486259 and REF_RGD_ID:2301880PpargChinchillaresponse to dietary excess acts_upstream_of_or_withinISOPparg (Mus musculus)9068941 PMID:24703703MGIPMID:24703703PpargChinchillaresponse to estrogen  ISOPparg (Rattus norvegicus)9068941 RGDPMID:18769493 and REF_RGD_ID:2301869PpargChinchillaresponse to food involved_inISOPparg (Mus musculus)9068941 MGI:3830801 and PMID:19041764UniProtMGI:3830801 and PMID:19041764PpargChinchillaresponse to immobilization stress  ISOPparg (Rattus norvegicus)9068941 RGDPMID:15820709 and REF_RGD_ID:8553018PpargChinchillaresponse to light stimulus involved_inISOPparg (Mus musculus)9068941 MGI:3830801 and PMID:19041764UniProtMGI:3830801 and PMID:19041764PpargChinchillaresponse to linoleic acid  ISOPparg (Rattus norvegicus)9068941 RGDPMID:18304850 and REF_RGD_ID:2301865PpargChinchillaresponse to lipid  ISOPparg (Rattus norvegicus)9068941 RGDPMID:19251397 and REF_RGD_ID:8553038PpargChinchillaresponse to lipid involved_inISOPparg (Mus musculus)9068941 MGI:3793920 and PMID:9568715BHF-UCLMGI:3793920 and PMID:9568715PpargChinchillaresponse to mechanical stimulus  ISOPparg (Rattus norvegicus)9068941skeletal unloadingRGDPMID:15572034 and REF_RGD_ID:8553192PpargChinchillaresponse to organic cyclic compound  ISOPparg (Rattus norvegicus)9068941 RGDPMID:18520050 and REF_RGD_ID:2301855PpargChinchillaresponse to starvation  ISOPparg (Rattus norvegicus)9068941 RGDPMID:19157823 and REF_RGD_ID:8553194PpargChinchillaresponse to vitamin A  ISOPparg (Rattus norvegicus)9068941 RGDPMID:18384703 and REF_RGD_ID:2301891PpargChinchillaresponse to xenobiotic stimulus  ISOPparg (Rattus norvegicus)9068941 RGDPMID:18846335 and REF_RGD_ID:2301867PpargChinchillaresponse to xenobiotic stimulus  ISOPparg (Rattus norvegicus)9068941eplerenoneRGDPMID:21451213 and REF_RGD_ID:7175336PpargChinchillaretinoic acid receptor signaling pathway involved_inISOPparg (Mus musculus)9068941 MGI:5447618 and PMID:16239304GO_CentralMGI:5447618 and PMID:16239304PpargChinchillaretinoic acid receptor signaling pathway involved_inISOPPARG (Sus scrofa)9068941 PMID:16239304GO_CentralPMID:16239304PpargChinchillaretinoic acid receptor signaling pathway involved_inISOPPARG (Homo sapiens)9068941 PMID:16239304GO_CentralPMID:16239304PpargChinchillasignal transduction involved_inISOPPARG (Homo sapiens)9068941 PMID:9568716BHF-UCLPMID:9568716PpargChinchillawhite fat cell differentiation acts_upstream_of_or_withinISOPparg (Mus musculus)9068941 PMID:18492766MGIPMID:18492766PpargChinchillawhite fat cell differentiation acts_upstream_of_or_withinISOMGI:10963939068941 PMID:17905753MGIPMID:17905753PpargChinchillawound healing involved in inflammatory response acts_upstream_of_or_within_negative_effectISOPparg (Mus musculus)9068941 MGI:5462034 and PMID:21880694BHF-UCLMGI:5462034 and PMID:21880694

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)PpargChinchillacytoplasm located_inISOPparg (Mus musculus)9068941 MGI:4457955 and PMID:20498072UniProtMGI:4457955 and PMID:20498072PpargChinchillacytosol located_inISOPparg (Mus musculus)9068941 PMID:12163159 and PMID:15164767MGIPMID:12163159 and PMID:15164767PpargChinchillaintracellular membrane-bounded organelle located_inISOPPARG (Homo sapiens)9068941 HPAGO_REF:0000052PpargChinchillanucleoplasm located_inISOPPARG (Homo sapiens)9068941 HPAGO_REF:0000052PpargChinchillanucleus is_active_inISOPPARG (Homo sapiens)9068941 PMID:18382765BHF-UCLPMID:18382765PpargChinchillanucleus located_inISOPparg (Mus musculus)9068941 MGI:4457955 more ...MGIMGI:4457955 more ...PpargChinchillanucleus located_inISOPPARG (Sus scrofa)9068941 PMID:23296834AgBasePMID:23296834PpargChinchillanucleus located_inISOPPARG (Homo sapiens)9068941 PMID:9568716BHF-UCLPMID:9568716PpargChinchillaperinuclear region of cytoplasm  ISOPparg (Rattus norvegicus)9068941 RGDPMID:15774612 and REF_RGD_ID:8553034PpargChinchillareceptor complex part_ofISOPPARG (Homo sapiens)9068941 PMID:19043829UniProtPMID:19043829PpargChinchillaRNA polymerase II transcription regulator complex part_ofISOPPARG (Homo sapiens)9068941 PMID:16373399 and PMID:9568716ComplexPortalPMID:16373399 and PMID:9568716PpargChinchillaRNA polymerase II transcription regulator complex part_ofISOPPARG (Homo sapiens)9068941 PMID:15258145ComplexPortalPMID:15258145PpargChinchillaSUMO ligase complex part_ofISOPparg (Mus musculus)9068941 PMID:22207709MGIPMID:22207709

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)PpargChinchillaalpha-actinin binding enablesISOUniProtKB:O437079068941 PMID:22351778UniProtPMID:22351778PpargChinchillaarachidonic acid binding enablesISOPparg (Mus musculus)9068941 MGI:3793920 and PMID:9568715BHF-UCLMGI:3793920 and PMID:9568715PpargChinchillachromatin binding enablesISOPparg (Mus musculus)9068941 MGI:4881351 more ...MGIMGI:4881351 more ...PpargChinchillaDNA binding enablesISOPPARG (Homo sapiens)9068941 PMID:18382765BHF-UCLPMID:18382765PpargChinchillaDNA binding enablesISOPparg (Mus musculus)9068941 PMID:12037571 and PMID:8041794MGIPMID:12037571 and PMID:8041794PpargChinchillaDNA binding  ISOPparg (Rattus norvegicus)9068941 RGDPMID:16257923 and REF_RGD_ID:1580658PpargChinchillaDNA binding domain binding enablesISOPPARG (Homo sapiens)9068941 PMID:19043829CAFAPMID:19043829PpargChinchillaDNA-binding transcription activator activity, RNA polymerase II-specific enablesISOPPARG (Homo sapiens)9068941 PMID:25704091BHF-UCLPMID:25704091PpargChinchillaDNA-binding transcription activator activity, RNA polymerase II-specific enablesISOPparg (Mus musculus)9068941 PMID:23275342MGIPMID:23275342PpargChinchillaDNA-binding transcription factor activity enablesISOPPARG (Homo sapiens)9068941 PMID:9568715BHF-UCLPMID:9568715PpargChinchillaDNA-binding transcription factor activity enablesISOPparg (Mus musculus)9068941 MGI:4881351 more ...UniProtMGI:4881351 more ...PpargChinchillaDNA-binding transcription factor activity enablesISOPparg (Rattus norvegicus)9068941PMID:19383491BHF-UCLPMID:19383491 and REF_RGD_ID:8553457PpargChinchillaDNA-binding transcription factor binding enablesISOUniProtKB:P422249068941 PMID:26504087UniProtPMID:26504087PpargChinchillaDNA-binding transcription factor binding enablesISOPPARG (Homo sapiens)9068941 PMID:10622252BHF-UCLPMID:10622252PpargChinchilladouble-stranded DNA binding enablesISOUniProtKB:P197939068941 PMID:19043829CAFAPMID:19043829PpargChinchillaE-box binding enablesISOPparg (Mus musculus)9068941 MGI:3830801 and PMID:19041764UniProtMGI:3830801 and PMID:19041764PpargChinchillaenzyme binding enablesISOUniProtKB:P553459068941 PMID:12039952UniProtPMID:12039952PpargChinchillaidentical protein binding enablesISOUniProtKB:P372319068941 PMID:25609649IntActPMID:25609649PpargChinchillaidentical protein binding enablesISOUniProtKB:P37231-19068941 PMID:17937915IntActPMID:17937915PpargChinchillaLBD domain binding enablesISOPPARG (Homo sapiens)9068941 PMID:19043829CAFAPMID:19043829PpargChinchillanuclear estrogen receptor binding  ISOEsr2 (Rattus norvegicus)9068941 RGDPMID:20689342 and REF_RGD_ID:8553035PpargChinchillanuclear receptor activity enablesISOPPARG (Homo sapiens)9068941 PMID:10622252 more ...BHF-UCLPMID:10622252 more ...PpargChinchillanuclear receptor activity enablesISOPPARG (Sus scrofa)9068941 PMID:16239304GO_CentralPMID:16239304PpargChinchillanuclear receptor activity enablesISOPparg (Mus musculus)9068941 MGI:5447618 and PMID:16239304GO_CentralMGI:5447618 and PMID:16239304PpargChinchillanuclear receptor coactivator activity enablesISOPparg (Mus musculus)9068941 MGI:4881351 and PMID:21035761UniProtMGI:4881351 and PMID:21035761PpargChinchillanuclear retinoid X receptor binding enablesISOUniProtKB:P197939068941 PMID:19043829CAFAPMID:19043829PpargChinchillanuclear retinoid X receptor binding enablesISOPPARG (Homo sapiens)9068941 PMID:9568715BHF-UCLPMID:9568715PpargChinchillanucleic acid binding enablesISOPPARG (Homo sapiens)9068941 PMID:19043829DisProtPMID:19043829PpargChinchillapeptide binding enablesISOPPARG (Homo sapiens)9068941 PMID:19043829CAFAPMID:19043829PpargChinchillapromoter-specific chromatin binding enablesISOPparg (Mus musculus)9068941 PMID:29519872MGIPMID:29519872PpargChinchillaprotein binding enablesISOPR:Q6RI639068941 PMID:17595322MGIPMID:17595322PpargChinchillaprotein binding enablesISOUniProtKB:Q99J479068941 PMID:28930673MGIPMID:28930673PpargChinchillaprotein binding enablesISOPR:Q9EPK59068941 PMID:16099986MGIPMID:16099986PpargChinchillaprotein binding enablesISOPR:Q8VEB29068941 PMID:22292086MGIPMID:22292086PpargChinchillaprotein binding enablesISOPR:Q9WU429068941 PMID:15681609MGIPMID:15681609PpargChinchillaprotein binding enablesISOUniProtKB:P19793 and UniProtKB:P287029068941 PMID:20211142 and PMID:25609649IntActPMID:20211142 and PMID:25609649PpargChinchillaprotein binding enablesISOUniProtKB:O753769068941 PMID:21775429IntActPMID:21775429PpargChinchillaprotein binding enablesISOUniProtKB:P10276 more ...9068941 PMID:32296183IntActPMID:32296183PpargChinchillaprotein binding enablesISOUniProtKB:Q6STE5-1 and UniProtKB:Q6STE5-29068941 PMID:14701856IntActPMID:14701856PpargChinchillaprotein binding enablesISOUniProtKB:P55055-1 and UniProtKB:Q131339068941 PMID:15722453IntActPMID:15722453PpargChinchillaprotein binding enablesISOUniProtKB:P197939068941 PMID:19043829 more ...UniProtPMID:19043829 more ...PpargChinchillaprotein binding enablesISOUniProtKB:O75376 and UniProtKB:P197939068941 PMID:35140242IntActPMID:35140242PpargChinchillaprotein binding enablesISOUniProtKB:Q925J99068941 MGI:1097733 and PMID:9325263UniProtMGI:1097733 and PMID:9325263PpargChinchillaprotein binding enablesISOUniProtKB:Q923E49068941 MGI:3045940 and PMID:15175761IntActMGI:3045940 and PMID:15175761PpargChinchillaprotein binding enablesISOUniProtKB:O437079068941 PMID:22351778UniProtPMID:22351778PpargChinchillaprotein binding enablesISOUniProtKB:Q005359068941 PMID:22078880IntActPMID:22078880PpargChinchillaprotein binding enablesISOUniProtKB:Q9BYK89068941 PMID:16239304UniProtPMID:16239304PpargChinchillaprotein binding  ISORad21 (Rattus norvegicus)9068941 RGDPMID:36538854 and REF_RGD_ID:243065265PpargChinchillaprotein binding enablesISOUniProtKB:P109099068941 PMID:20195357IntActPMID:20195357PpargChinchillaprotein binding enablesISOUniProtKB:P428589068941 PMID:17500595 and PMID:32814053IntActPMID:17500595 and PMID:32814053PpargChinchillaprotein binding enablesISOUniProtKB:Q9UBK29068941 PMID:12522104 and PMID:19846556IntActPMID:12522104 and PMID:19846556PpargChinchillaprotein binding enablesISOUniProtKB:Q96EB69068941 PMID:20660480IntActPMID:20660480PpargChinchillaprotein binding enablesISOUniProtKB:P170969068941 PMID:10428834UniProtPMID:10428834PpargChinchillaprotein binding enablesISOUniProtKB:O357109068941 MGI:4457955 and PMID:20498072UniProtMGI:4457955 and PMID:20498072PpargChinchillaprotein binding enablesISOUniProtKB:Q9R1E09068941 MGI:5567909 and PMID:19037106UniProtMGI:5567909 and PMID:19037106PpargChinchillaprotein binding enablesISOUniProtKB:Q923E4 more ...9068941 MGI:5438686 and PMID:22863012IntActMGI:5438686 and PMID:22863012PpargChinchillaprotein binding enablesISOUniProtKB:O889079068941 MGI:3604169 and PMID:16127449BHF-UCLMGI:3604169 and PMID:16127449PpargChinchillaprotein binding enablesISOUniProtKB:A2A9359068941 MGI:3806432 and PMID:18719582UniProtMGI:3806432 and PMID:18719582PpargChinchillaprotein binding enablesISOUniProtKB:O549439068941 MGI:4881351 and PMID:21035761UniProtMGI:4881351 and PMID:21035761PpargChinchillaprotein binding enablesISOUniProtKB:P97784 and UniProtKB:Q9R1949068941 MGI:6107163 and PMID:28683290UniProtMGI:6107163 and PMID:28683290PpargChinchillaprotein binding enablesISOUniProtKB:P974319068941 MGI:6294168 and PMID:28526834IntActMGI:6294168 and PMID:28526834PpargChinchillaprotein binding enablesISOUniProtKB:P041179068941 MGI:6158968 and PMID:12077340UniProtMGI:6158968 and PMID:12077340PpargChinchillaprotein binding  ISOIkbkg (Rattus norvegicus)9068941 RGDPMID:18828195 and REF_RGD_ID:8553037PpargChinchillaprotein binding  ISONcoa1 (Rattus norvegicus)9068941 RGDPMID:19485965 and REF_RGD_ID:5688171PpargChinchillaprotein binding enablesISOUniProtKB:O608699068941 PMID:12040021UniProtPMID:12040021PpargChinchillaprotein phosphatase binding  ISOPparg (Rattus norvegicus)9068941calcineurinRGDPMID:18600431 and REF_RGD_ID:2301872PpargChinchillaR-SMAD binding enablesISOUniProtKB:P840229068941 PMID:31023188BHF-UCLPMID:31023188PpargChinchillaRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesISOPPARG (Homo sapiens)9068941 PMID:25704091BHF-UCLPMID:25704091PpargChinchillaRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesISOPparg (Mus musculus)9068941 PMID:15232616 more ...MGIPMID:15232616 more ...PpargChinchillaRNA polymerase II core promoter sequence-specific DNA binding enablesISOPparg (Mus musculus)9068941 PMID:25921091MGIPMID:25921091PpargChinchillaRNA polymerase II transcription regulatory region sequence-specific DNA binding enablesISOPparg (Mus musculus)9068941 PMID:15175325MGIPMID:15175325PpargChinchillasequence-specific DNA binding enablesISOPPARG (Homo sapiens)9068941 PMID:9568716BHF-UCLPMID:9568716PpargChinchillaSTAT family protein binding enablesISOUniProtKB:P407639068941 PMID:28467929ARUK-UCLPMID:28467929PpargChinchillatranscription cis-regulatory region binding enablesISOPPARG (Homo sapiens)9068941 PMID:18293083BHF-UCLPMID:18293083PpargChinchillatranscription cis-regulatory region binding enablesISOPparg (Rattus norvegicus)9068941PMID:19383491BHF-UCLPMID:19383491 and REF_RGD_ID:8553457PpargChinchillatranscription cis-regulatory region binding enablesISOPparg (Mus musculus)9068941 MGI:3604169 more ...UniProtMGI:3604169 more ...PpargChinchillatranscription coactivator binding  ISOMed1 (Rattus norvegicus)9068941 RGDPMID:10037764 and REF_RGD_ID:5134969PpargChinchillatranscription coregulator binding enablesISOUniProtKB:Q6STE59068941 PMID:14701856UniProtPMID:14701856PpargChinchillatranscription factor binding  ISONfatc4 (Rattus norvegicus)9068941 RGDPMID:18600431 and REF_RGD_ID:2301872PpargChinchillaWW domain binding enablesISOPPARG (Homo sapiens)9068941 PMID:22292086MGIPMID:22292086PpargChinchillazinc ion binding enablesISOPPARG (Homo sapiens)9068941 PMID:19043829CAFAPMID:19043829

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)PpargChinchillaDNA modification pathway   ISOPPARG (Homo sapiens)9068941 RGDPMID:24825349 and REF_RGD_ID:8695944

Imported Annotations - PID (archival)

Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)PpargChinchillaWnt signaling, non-canonical pathway  ISOPPARG (Homo sapiens)9068941 PIDPID:200020
Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome  (ISO)
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
acute promyelocytic leukemia  (ISO)
adenocarcinoma  (ISO)
alcoholic cardiomyopathy  (ISO)
Alveolar Bone Loss  (ISO)
Alzheimer's disease  (ISO)
antiphospholipid syndrome  (ISO)
arteriosclerosis  (ISO)
atherosclerosis  (ISO)
autosomal dominant polycystic kidney disease  (ISO)
Barrett's esophagus  (ISO)
cardiovascular system disease  (ISO)
carotid artery disease  (ISO)
Carotid Artery Injuries  (ISO)
Carotid Intimal Medial Thickness 1  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chronic Allograft Nephropathy  (ISO)
Chronobiology Disorders  (ISO)
cognitive disorder  (ISO)
colon cancer  (ISO)
colon carcinoma  (ISO)
Colonic Neoplasms  (ISO)
Colorectal Neoplasms  (ISO)
congenital generalized lipodystrophy type 2  (ISO)
congestive heart failure  (ISO)
corneal neovascularization  (ISO)
coronary artery disease  (ISO)
COVID-19  (ISO)
Crohn's disease  (ISO)
diabetes mellitus  (ISO)
diabetic encephalopathy  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
disease of metabolism  (ISO)
Dyslipidemias  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Eye Burns  (ISO)
Eye Injuries  (ISO)
familial partial lipodystrophy  (ISO)
familial partial lipodystrophy type 3  (ISO)
Fetal Growth Retardation  (ISO)
Fibrosis  (ISO)
Follicular Thyroid Cancer  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
glomerulonephritis  (ISO)
glomerulosclerosis  (ISO)
Graves ophthalmopathy  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
hyperandrogenism  (ISO)
hypertension  (ISO)
Inflammation  (ISO)
Insulin Resistance  (ISO)
ischemia  (ISO)
kidney failure  (ISO)
Left Ventricular Hypertrophy  (ISO)
leukostasis  (ISO)
lipid storage disease  (ISO)
lipodystrophy  (ISO)
Liver Neoplasms  (ISO)
Lymphatic Metastasis  (ISO)
maturity-onset diabetes of the young type 1  (ISO)
melanoma  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (ISO)
morbid obesity  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nerve Degeneration  (ISO)
obesity  (ISO)
osteoarthritis  (ISO)
Oxygen-Induced Retinopathy  (ISO)
Pain  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
pancreatitis  (ISO)
Perennial Allergic Rhinitis  (ISO)
pituitary-dependent Cushing's disease  (ISO)
polycystic kidney disease  (ISO)
pre-eclampsia  (ISO)
primary pulmonary hypertension  (ISO)
proliferative diabetic retinopathy  (ISO)
psoriasis  (ISO)
Reperfusion Injury  (ISO)
steatotic liver disease  (ISO)
Stomach Neoplasms  (ISO)
Subarachnoid Hemorrhage  (ISO)
systemic lupus erythematosus  (ISO)
T-cell non-Hodgkin lymphoma  (ISO)
Thyroid Neoplasms  (ISO)
transient cerebral ischemia  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (ISO)
BMP signaling pathway  (ISO)
brown fat cell differentiation  (ISO)
cell fate commitment  (ISO)
cell maturation  (ISO)
cell population proliferation  (ISO)
cellular response to hyperoxia  (ISO)
cellular response to hypoxia  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to lithium ion  (ISO)
cellular response to low-density lipoprotein particle stimulus  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to platelet-derived growth factor stimulus  (ISO)
cellular response to prostaglandin E stimulus  (ISO)
cellular response to prostaglandin stimulus  (ISO)
cellular response to retinoic acid  (ISO)
cellular response to vitamin E  (ISO)
cold-induced thermogenesis  (ISO)
diet induced thermogenesis  (ISO)
epithelial cell differentiation  (ISO)
epithelial cell proliferation  (ISO)
fat cell differentiation  (ISO)
fatty acid oxidation  (ISO)
glucose homeostasis  (ISO)
heart development  (ISO)
lipoprotein transport  (ISO)
long-chain fatty acid transport  (ISO)
macrophage derived foam cell differentiation  (ISO)
monocyte differentiation  (ISO)
mRNA transcription by RNA polymerase II  (ISO)
negative regulation of acute inflammatory response  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of blood vessel endothelial cell migration  (ISO)
negative regulation of BMP signaling pathway  (ISO)
negative regulation of cardiac muscle hypertrophy in response to stress  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cellular response to insulin stimulus  (ISO)
negative regulation of cellular response to transforming growth factor beta stimulus  (ISO)
negative regulation of cholesterol storage  (ISO)
negative regulation of collagen biosynthetic process  (ISO)
negative regulation of connective tissue replacement involved in inflammatory response wound healing  (ISO)
negative regulation of cytokine production  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of extracellular matrix assembly  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of lipid storage  (ISO)
negative regulation of macrophage derived foam cell differentiation  (ISO)
negative regulation of MAPK cascade  (ISO)
negative regulation of microglial cell activation  (ISO)
negative regulation of miRNA transcription  (ISO)
negative regulation of mitochondrial fission  (ISO)
negative regulation of neuroinflammatory response  (ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of pancreatic stellate cell proliferation  (ISO)
negative regulation of peptide hormone secretion  (ISO)
negative regulation of receptor signaling pathway via STAT  (ISO)
negative regulation of sequestering of triglyceride  (ISO)
negative regulation of SMAD protein signal transduction  (ISO)
negative regulation of smooth muscle cell migration  (ISO)
negative regulation of smooth muscle cell proliferation  (ISO)
negative regulation of telomerase activity  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
negative regulation of type II interferon-mediated signaling pathway  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
negative regulation of vascular endothelial cell proliferation  (ISO)
peroxisome proliferator activated receptor signaling pathway  (ISO)
placenta development  (ISO)
positive regulation of adiponectin secretion  (ISO)
positive regulation of adipose tissue development  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of apoptotic signaling pathway  (ISO)
positive regulation of cholesterol efflux  (ISO)
positive regulation of cholesterol transport  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of fat cell differentiation  (ISO)
positive regulation of fatty acid oxidation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of intracellular cholesterol transport  (ISO)
positive regulation of miRNA transcription  (ISO)
positive regulation of oligodendrocyte differentiation  (ISO)
positive regulation of phagocytosis, engulfment  (ISO)
positive regulation of prostaglandin biosynthetic process  (ISO)
positive regulation of protein secretion  (ISO)
positive regulation of SMAD protein signal transduction  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of vascular associated smooth muscle cell apoptotic process  (ISO)
regulation of blood pressure  (ISO)
regulation of circadian rhythm  (ISO)
regulation of DNA-templated transcription  (ISO)
regulation of fat cell differentiation  (ISO)
regulation of gene expression  (ISO)
regulation of lipid metabolic process  (ISO)
regulation of protein localization to plasma membrane  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
response to caffeine  (ISO)
response to dietary excess  (ISO)
response to estrogen  (ISO)
response to food  (ISO)
response to immobilization stress  (ISO)
response to light stimulus  (ISO)
response to linoleic acid  (ISO)
response to lipid  (ISO)
response to mechanical stimulus  (ISO)
response to organic cyclic compound  (ISO)
response to starvation  (ISO)
response to vitamin A  (ISO)
response to xenobiotic stimulus  (ISO)
retinoic acid receptor signaling pathway  (ISO)
signal transduction  (ISO)
white fat cell differentiation  (ISO)
wound healing involved in inflammatory response  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Pparg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542914,873,908 - 14,937,387 (+)EnsemblChiLan1.0ChiLan1.0NW_00495542914,814,690 - 14,936,869 (+)NCBIChiLan1.0ChiLan1.0
PPARG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38312,287,368 - 12,434,344 (+)NCBIGRCh38GRCh38hg38GRCh38GRCh38.p14 Ensembl312,287,368 - 12,434,356 (+)EnsemblGRCh38hg38GRCh38GRCh37312,328,867 - 12,475,843 (+)NCBIGRCh37GRCh37hg19GRCh37Build 36312,304,349 - 12,450,855 (+)NCBINCBI36Build 36hg18NCBI36Build 34312,304,423 - 12,450,840NCBICelera312,266,744 - 12,413,226 (+)NCBICeleraCytogenetic Map3p25.2NCBIHuRef312,263,090 - 12,409,169 (+)NCBIHuRefCHM1_1312,279,448 - 12,425,942 (+)NCBICHM1_1T2T-CHM13v2.0312,285,564 - 12,432,191 (+)NCBIT2T-CHM13v2.0
Pparg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396115,337,828 - 115,467,365 (+)NCBIGRCm39GRCm39mm39GRCm39 Ensembl6115,337,912 - 115,467,360 (+)EnsemblGRCm39 EnsemblGRCm386115,360,879 - 115,490,404 (+)NCBIGRCm38GRCm38mm10GRCm38GRCm38.p6 Ensembl6115,360,951 - 115,490,399 (+)EnsemblGRCm38mm10GRCm38MGSCv376115,311,239 - 115,440,419 (+)NCBIGRCm37MGSCv37mm9NCBIm37MGSCv366115,387,692 - 115,456,020 (+)NCBIMGSCv36mm8Celera6117,199,637 - 117,329,691 (+)NCBICeleraCytogenetic Map6E3NCBIcM Map653.41NCBI
Pparg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84150,095,743 - 150,221,104 (+)NCBIGRCr8mRatBN7.24148,423,102 - 148,548,471 (+)NCBImRatBN7.2mRatBN7.2mRatBN7.2 Ensembl4148,423,194 - 148,548,468 (+)EnsemblmRatBN7.2 EnsemblUTH_Rnor_SHR_Utx4154,648,115 - 154,772,735 (+)NCBIRnor_SHRUTH_Rnor_SHR_UtxUTH_Rnor_SHRSP_BbbUtx_1.04150,431,203 - 150,555,814 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_WKY_Bbb_1.04149,055,023 - 149,179,637 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0Rnor_6.04147,274,055 - 147,399,383 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0Rnor_6.0 Ensembl4147,274,107 - 147,399,380 (+)EnsemblRnor6.0rn6Rnor6.0Rnor_5.04210,562,928 - 210,688,585 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0RGSC_v3.44151,492,220 - 151,617,331 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4RGSC_v3.14151,796,047 - 151,862,171 (+)NCBICelera4137,316,681 - 137,440,473 (+)NCBICeleraCytogenetic Map4q42NCBI
PPARG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2212,275,725 - 12,421,769 (+)NCBINHGRI_mPanPan1-v2NHGRI_mPanPan1312,280,497 - 12,426,762 (+)NCBINHGRI_mPanPan1Mhudiblu_PPA_v0312,215,322 - 12,361,669 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3PanPan1.1312,560,670 - 12,705,060 (+)NCBIpanpan1.1PanPan1.1panPan2PanPan1.1 Ensembl312,622,397 - 12,705,060 (+)Ensemblpanpan1.1panPan2
PPARG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1206,134,618 - 6,265,481 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1CanFam3.1 Ensembl206,050,357 - 6,207,981 (-)EnsemblCanFam3.1canFam3CanFam3.1Dog10K_Boxer_Tasha206,170,697 - 6,244,070 (-)NCBIDog10K_Boxer_TashaROS_Cfam_1.0206,163,453 - 6,294,865 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0 Ensembl206,163,453 - 6,236,837 (-)EnsemblROS_Cfam_1.0 EnsemblUMICH_Zoey_3.1205,878,834 - 5,952,191 (-)NCBIUMICH_Zoey_3.1UNSW_CanFamBas_1.0206,232,700 - 6,306,060 (-)NCBIUNSW_CanFamBas_1.0UU_Cfam_GSD_1.0206,208,181 - 6,281,750 (-)NCBIUU_Cfam_GSD_1.0
Pparg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494217,541,121 - 17,706,796 (+)NCBIHiC_Itri_2SpeTri2.0 EnsemblNW_0049366021,230,907 - 1,304,743 (-)EnsemblSpeTri2.0SpeTri2.0 EnsemblSpeTri2.0NW_0049366021,230,907 - 1,368,588 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPARG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1368,302,322 - 68,433,944 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1Sscrofa11.11368,301,566 - 68,433,951 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1Sscrofa10.21375,515,515 - 75,650,251 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPARG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12248,262,743 - 48,407,415 (+)NCBIChlSab1.1ChlSab1.1chlSab2ChlSab1.1 Ensembl2248,275,600 - 48,407,418 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2Vero_WHO_p1.0NW_023666041118,092,724 - 118,237,828 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pparg
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462495683,842 - 149,481 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2HetGla 1.0NW_00462495684,673 - 207,176 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005387017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005387018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005387019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AGCD01028785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01028786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01028787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GBCQ01128594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSCLAT00000021746   ⟹   ENSCLAP00000021543
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542914,873,908 - 14,937,387 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000021747   ⟹   ENSCLAP00000021544
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542914,875,680 - 14,936,710 (+)Ensembl
RefSeq Acc Id: XM_005387017   ⟹   XP_005387074
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542914,814,690 - 14,936,869 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005387018   ⟹   XP_005387075
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542914,814,690 - 14,936,869 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005387019   ⟹   XP_005387076
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542914,814,693 - 14,936,869 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005387074 (Get FASTA)   NCBI Sequence Viewer  
  XP_005387075 (Get FASTA)   NCBI Sequence Viewer  
  XP_005387076 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000021543
  ENSCLAP00000021543.1
  ENSCLAP00000021544.1
RefSeq Acc Id: XP_005387074   ⟸   XM_005387017
- UniProtKB: A0A8C2VW58 (UniProtKB/TrEMBL),   A0A8C2VWJ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005387075   ⟸   XM_005387018
- UniProtKB: A0A8C2VW58 (UniProtKB/TrEMBL),   A0A8C2VWJ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005387076   ⟸   XM_005387019
- UniProtKB: A0A8C2VW58 (UniProtKB/TrEMBL),   A0A8C2VWJ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000021544   ⟸   ENSCLAT00000021747
RefSeq Acc Id: ENSCLAP00000021543   ⟸   ENSCLAT00000021746
Protein Domains
NR LBD   Nuclear receptor


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000014746 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000021746 ENTREZGENE
  ENSCLAT00000021746.1 UniProtKB/TrEMBL
  ENSCLAT00000021747.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.565.10 UniProtKB/TrEMBL
  3.30.50.10 UniProtKB/TrEMBL
InterPro 1Cnucl_rcpt UniProtKB/TrEMBL
  NHR-like_dom_sf UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/TrEMBL
  Nuclear_hrmn_rcpt UniProtKB/TrEMBL
  PPAR-gamma UniProtKB/TrEMBL
  PPARgamma_N UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/TrEMBL
NCBI Gene Pparg ENTREZGENE
PANTHER NUCLEAR HORMONE RECEPTOR UniProtKB/TrEMBL
  PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA UniProtKB/TrEMBL
Pfam Hormone_recep UniProtKB/TrEMBL
  PPARgamma_N UniProtKB/TrEMBL
  zf-C4 UniProtKB/TrEMBL
PRINTS PROXISOMEPAR UniProtKB/TrEMBL
  PROXISOMPAGR UniProtKB/TrEMBL
  STRDHORMONER UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/TrEMBL
SMART HOLI UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/TrEMBL
  SSF48508 UniProtKB/TrEMBL
UniProt A0A8C2VW58 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2VWJ8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Pparg  peroxisome proliferator activated receptor gamma    peroxisome proliferator-activated receptor gamma  Symbol and/or name change 5135510 APPROVED

 


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