In Drosophila and in vertebrates, the achaete-scute family of basic helix–loop–helix
transcription factors plays a critical developmental role in neuronal commitment and …

IN vertebrates, the peripheral nervous system is embryologically derived from the neural
crest1. Although the earliest neural crest cells seem to be multipotent2, 3, the molecular …

The achaete-scute genes encode essential transcription factors in normal Drosophila and
vertebrate nervous system development. Human achaete-scute homolog-1 (hASH1) is …

Basic helix-loop-helix transcription factors of the achaete-scute family are instrumental in
Drosophila neurosensory development and are candidate regulators of development in the …

The proneural basic-helix-loop-helix protein achaete-scute homologue 1 (ASH1) is
expressed in a very limited spectrum of normal and cancerous cells in a lineage-specific …

Lung cancers with neuroendocrine features are usually aggressive, although the underlying
molecular mechanisms largely remain to be determined. The basic helix-loop-helix protein …

THE outer layer of the blastocyst, or trophectoderm, is the first cell lineage to differentiate in
the mouse embryo1, 2, but little is known about the genetic control of its development …

ABSTRACT MASH1 and MASH2, mammalian homologues of the Drosophila neural
determination genes achaete-scute, are members of the basic helix-loop-helix (bHLH) family …

To clarify the mechanisms that regulate neuroendocrine differentiation of fetal lung epithelia,
we have studied the expression of the mammalian homologs of achaete-scute complex …

THE Drosophila peripheral nervous system comprises four major types of sensory element:
external sense organs (such as mechano-sensory bristles), chordotonal organs (internal …