The potential use of mesenchymal stem cells and their exosomes in Parkinson's disease treatment

RM Heris, M Shirvaliloo, S Abbaspour-Aghdam… - Stem Cell Research & …, 2022 - Springer
Parkinson's disease (PD) is the second most predominant neurodegenerative disease
worldwide. It is recognized clinically by severe complications in motor function caused by …

Mesenchymal stem cells-derived exosomes: a new possible therapeutic strategy for Parkinson's disease?

H Vilaça-Faria, AJ Salgado, FG Teixeira - Cells, 2019 - mdpi.com
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder
worldwide. Clinically, it is characterized by severe motor complications caused by a …

Exosomes derived from mesenchymal stem cells repair a Parkinson's disease model by inducing autophagy

HX Chen, FC Liang, P Gu, BL Xu, HJ Xu… - Cell death & …, 2020 - nature.com
Parkinson's disease (PD) is a progressively debilitating neurodegenerative condition that
leads to motor and cognitive dysfunction. At present, clinical treatment can only improve …

Stem cell-derived exosomes: a new strategy of neurodegenerative disease treatment

N Fayazi, M Sheykhhasan, S Soleimani Asl… - Molecular …, 2021 - Springer
Short-term symptomatic treatment and dose-dependent side effects of pharmacological
treatment for neurodegenerative diseases have forced the medical community to seek an …

The therapeutic potential of mesenchymal stem cell–derived exosomes in treatment of neurodegenerative diseases

AM Gorabi, N Kiaie, GE Barreto, MI Read, HA Tafti… - Molecular …, 2019 - Springer
Neurologic complications are commonly regarded as irreversible impairments that stem from
limited potential of regeneration of the central nervous system (CNS). On the other side, the …

Exosomes derived from human umbilical cord mesenchymal stem cells alleviate Parkinson's disease and neuronal damage through inhibition of microglia

ZX Zhang, YJ Zhou, P Gu, W Zhao… - Neural Regeneration …, 2023 - journals.lww.com
Microglia-mediated inflammatory responses have been shown to play a crucial role in
Parkinson's disease. In addition, exosomes derived from mesenchymal stem cells have …

Insights into the effects of mesenchymal stem cell-derived secretome in Parkinson's disease

M d'Angelo, A Cimini, V Castelli - International Journal of Molecular …, 2020 - mdpi.com
Mesenchymal stem cell (MSC)-derived secretome demonstrated therapeutic effects like
those reported after MSCs transplantation. MSC-derived secretome may avoid various side …

[HTML][HTML] Advances in treatment of neurodegenerative diseases: perspectives for combination of stem cells with neurotrophic factors

J Wang, WW Hu, Z Jiang, MJ Feng - World journal of stem cells, 2020 - ncbi.nlm.nih.gov
Neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease,
Huntington's disease and amyotrophic lateral sclerosis, are a group of incurable …

Promising opportunities for treating neurodegenerative diseases with mesenchymal stem cell-derived exosomes

R Guy, D Offen - Biomolecules, 2020 - mdpi.com
Neurodegenerative disease refers to any pathological condition in which there is a
progressive decline in neuronal function resulting from brain atrophy. Despite the immense …

Bone marrow mesenchymal stem cells' secretome exerts neuroprotective effects in a Parkinson's disease rat model

B Mendes-Pinheiro, SI Anjo, B Manadas… - … in bioengineering and …, 2019 - frontiersin.org
Parkinson's disease (PD) is characterized by a selective loss of dopamine (DA) neurons in
the human midbrain causing motor dysfunctions. The exact mechanism behind …