DNA microarrays identification of primary and secondary target genes regulated by p53
K Kannan, N Amariglio, G Rechavi, J Jakob-Hirsch… - Oncogene, 2001 - nature.com
The transcriptional program regulated by the tumor suppressor p53 was analysed using
oligonucleotide microarrays. A human lung cancer cell line that expresses the temperature …
oligonucleotide microarrays. A human lung cancer cell line that expresses the temperature …
Analysis of p53-regulated gene expression patterns using oligonucleotide arrays
R Zhao, K Gish, M Murphy, Y Yin… - Genes & …, 2000 - genesdev.cshlp.org
Oligonucleotide microarrays were employed to quantitate mRNA levels from a large number
of genes regulated by the p53 transcription factor. Responses to DNA damage and to zinc …
of genes regulated by the p53 transcription factor. Responses to DNA damage and to zinc …
Analyses of p53 Target Genes in the Human Genome by Bioinformatic and Microarray Approaches* 210
L Wang, Q Wu, P Qiu, A Mirza, M McGuirk… - Journal of Biological …, 2001 - ASBMB
The completion of the human genome sequence (International Human Genome Sequence
Consortium (2001) Nature 409, 860–921; Venter, JC, et al.(2001) Science 291, 1304–1351) …
Consortium (2001) Nature 409, 860–921; Venter, JC, et al.(2001) Science 291, 1304–1351) …
More targets, more pathways and more clues for mutant p53
S Garritano, A Inga, F Gemignani, S Landi - Oncogenesis, 2013 - nature.com
Mutations in the transcription factor p53 are among the most common genetic alterations in
human cancer, and missense p53 mutations in cancer cells can lead to aggressive …
human cancer, and missense p53 mutations in cancer cells can lead to aggressive …
Tissue microarray technology for high-throughput molecular profiling of cancer
OP Kallioniemi, U Wagner, J Kononen… - Human molecular …, 2001 - academic.oup.com
Tissue microarray (TMA) technology allows rapid visualization of molecular targets in
thousands of tissue specimens at a time, either at the DNA, RNA or protein level. The …
thousands of tissue specimens at a time, either at the DNA, RNA or protein level. The …
DNA microarray analysis of genes involved in p53 mediated apoptosis: activation of Apaf-1
K Kannan, N Kaminski, G Rechavi, J Jakob-Hirsch… - Oncogene, 2001 - nature.com
The transcription regulation activity of p53 controls cellular response to a variety of stress
conditions, leading to growth arrest and apoptosis. Despite major progress in the …
conditions, leading to growth arrest and apoptosis. Despite major progress in the …
The p53MH algorithm and its application in detecting p53-responsive genes
J Hoh, S Jin, T Parrado, J Edington… - Proceedings of the …, 2002 - National Acad Sciences
A computer algorithm, p53MH, was developed, which identifies putative p53 transcription
factor DNA-binding sites on a genomewide scale with high power and versatility. With the …
factor DNA-binding sites on a genomewide scale with high power and versatility. With the …
Functional protein microarrays for parallel characterisation of p53 mutants
JM Boutell, DJ Hart, BLJ Godber, RZ Kozlowski… - …, 2004 - Wiley Online Library
Understanding the way in which single nucleotide polymorphisms and mutations in the
human genome result in individual susceptibility to disease is a major goal in the …
human genome result in individual susceptibility to disease is a major goal in the …
Modulation of gene expression by tumor-derived p53 mutants
MJ Scian, KER Stagliano, MA Ellis, S Hassan… - Cancer research, 2004 - AACR
Abstract p53 mutants with a single amino acid substitution are overexpressed in a majority of
human cancers containing a p53 mutation. Overexpression of the mutant protein suggests …
human cancers containing a p53 mutation. Overexpression of the mutant protein suggests …
A DNA microarray survey of gene expression in normal human tissues
R Shyamsundar, YH Kim, JP Higgins, K Montgomery… - Genome biology, 2005 - Springer
Background Numerous studies have used DNA microarrays to survey gene expression in
cancer and other disease states. Comparatively little is known about the genes expressed …
cancer and other disease states. Comparatively little is known about the genes expressed …