The transcriptional program regulated by the tumor suppressor p53 was analysed using
oligonucleotide microarrays. A human lung cancer cell line that expresses the temperature …

Oligonucleotide microarrays were employed to quantitate mRNA levels from a large number
of genes regulated by the p53 transcription factor. Responses to DNA damage and to zinc …

The completion of the human genome sequence (International Human Genome Sequence
Consortium (2001) Nature 409, 860–921; Venter, JC, et al.(2001) Science 291, 1304–1351) …

Mutations in the transcription factor p53 are among the most common genetic alterations in
human cancer, and missense p53 mutations in cancer cells can lead to aggressive …

Tissue microarray (TMA) technology allows rapid visualization of molecular targets in
thousands of tissue specimens at a time, either at the DNA, RNA or protein level. The …

The transcription regulation activity of p53 controls cellular response to a variety of stress
conditions, leading to growth arrest and apoptosis. Despite major progress in the …

A computer algorithm, p53MH, was developed, which identifies putative p53 transcription
factor DNA-binding sites on a genomewide scale with high power and versatility. With the …

Understanding the way in which single nucleotide polymorphisms and mutations in the
human genome result in individual susceptibility to disease is a major goal in the …

Abstract p53 mutants with a single amino acid substitution are overexpressed in a majority of
human cancers containing a p53 mutation. Overexpression of the mutant protein suggests …

Background Numerous studies have used DNA microarrays to survey gene expression in
cancer and other disease states. Comparatively little is known about the genes expressed …