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- Academic Editor
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Background: Due to its non-invasive and widely applicable features,
photodynamic therapy (PDT) has been a prominent treatment approach against cancer
in recent years. However, its widespread application in clinical practice is
limited by the dark toxicity of photosensitizers and insufficient penetration of
light sources. This study assessed the anticancer effects of a novel
photosensitizer 5-(4-amino-phenyl)-10,15,20-triphenylporphyrin with
diethylene-triaminopentaacetic acid (ATPP-DTPA)-mediated PDT (hereinafter referred to as ATPP-PDT) under the
irradiation of a 450-nm blue laser on colorectal cancer (CRC) in vivo
and in vitro. Methods: After 450-nm blue laser-mediated
ATPP-PDT and the traditional photosensitizer 5-aminolevulinic acid (5-ALA)-PDT
treatment, cell viability was detected through Cell Counting Kit-8 (CCK-8) and
5-ethynyl-2
![](https://article.imrpress.com/journal/FBL/29/5/10.31083/j.fbl2905199/2768-6698-29-5-199/fig1.jpg)