- Academic Editor
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†These authors contributed equally.
Aims: Changes in myocardial mitochondrial morphology
and function in premature ventricular contractions (PVCs)-induced cardiomyopathy
(PVCCM) remain poorly studied. Here, we investigated the effects of PVCs with
different coupling intervals (CIs) on myocardial mitochondrial remodelling in a
canine model of PVCCM. Methods and Results: Twenty-one beagles
underwent pacemaker implantation and were randomised into the sham (n = 7),
short-coupled PVCs (SCP, n = 7), and long-coupled PVCs (LCP, n = 7) groups. Right
ventricular (RV) apical bigeminy was produced
for 12-week to induce PVCCM in the SCP (CI, 250 ms) and LCP (CI, 350 ms) groups.
Echocardiography was performed at baseline and biweekly thereafter to evaluate
cardiac function. Masson’s trichrome staining measured ventricular interstitial
fibrosis. The ultrastructural morphology of the
myocardial mitochondria was analysed using
transmission electron microscopy. Mitochondrial Ca