| Phospholipase C beta 1 in the dentate gyrus gates fear memory formation through regulation of neuronal excitability. | Phospholipase C beta 1 in the dentate gyrus gates fear memory formation through regulation of neuronal excitability.
Lee J, Jeong Y, Park S, Kim S, Oh H, Jin JA, Sohn JW, Kim D, Shin HS, Heo WD., Free PMC Article | 07/29/2024 |
| Conformational alteration in glycan induces phospholipase Cbeta1 activation and angiogenesis. | Conformational alteration in glycan induces phospholipase Cβ1 activation and angiogenesis.
Wang SH, Cheng JY, Tsai HH, Lo TC, Hung JT, Lin CC, Lee CW, Ho YH, Kuo HH, Yu AL, Yu J., Free PMC Article | 01/11/2023 |
| Cell-autonomous PLCbeta1 modulation of neural stem/progenitor cell proliferation during adult hippocampal neurogenesis. | Cell-autonomous PLCβ1 modulation of neural stem/progenitor cell proliferation during adult hippocampal neurogenesis.
Song B, Kim CH. | 11/12/2022 |
| Activation of PLCbeta1 enhances endocannabinoid mobilization to restore hippocampal spike-timing-dependent potentiation and contextual fear memory impaired by Alzheimer's amyloidosis. | Activation of PLCβ1 enhances endocannabinoid mobilization to restore hippocampal spike-timing-dependent potentiation and contextual fear memory impaired by Alzheimer's amyloidosis.
Lee J, Kwag J., Free PMC Article | 11/6/2021 |
| The present study showed that PLC-beta1 was crucial for beta-cell function by generation of each PLC-beta conditional knockout mouse. Mice lacking PLC-beta1 in beta cells exhibited a marked defect in glucose-stimulated insulin secretion, leading to glucose intolerance. | Phospholipase C-β1 potentiates glucose-stimulated insulin secretion.
Hwang HJ, Yang YR, Kim HY, Choi Y, Park KS, Lee H, Ma JS, Yamamoto M, Kim J, Chae YC, Choi JH, Cocco L, Berggren PO, Jang HJ, Suh PG. | 06/6/2020 |
| Phospholipase C-Beta1 reduction leads to disturbances to beta and gamma oscillatory dynamics and pre-pulse inhibition behavior in an animal model of schizophrenia. | High-Frequency Neuronal Oscillatory Abnormalities in the Phospholipase C-β1 Knockout Mouse Model of Schizophrenia.
Hudson MR, Hannan AJ, O'Brien TJ, Jones NC., Free PMC Article | 02/1/2020 |
| Data show that phospholipase C (PLC)-beta1 (PLC-beta1) overexpression determines an increase in beta-catenin translocation and that PLC-beta1, inositol polyphosphate multikinase (IPMK) and beta-catenin are mediators of the same signaling pathway. | IPMK and β-catenin mediate PLC-β1-dependent signaling in myogenic differentiation.
Ramazzotti G, Billi AM, Manzoli L, Mazzetti C, Ruggeri A, Erneux C, Kim S, Suh PG, Cocco L, Faenza I., Free PMC Article | 03/10/2018 |
| functions in plasma membrane remodeling, particularly caveolae formation | Phospholipase Cβ1 induces membrane tubulation and is involved in caveolae formation.
Inaba T, Kishimoto T, Murate M, Tajima T, Sakai S, Abe M, Makino A, Tomishige N, Ishitsuka R, Ikeda Y, Takeoka S, Kobayashi T., Free PMC Article | 12/2/2017 |
| Plcb1 plays a crucial role in the initiation of the genetic program responsible for muscle differentiation and osteogenesis. (Review) | PLC-β1 and cell differentiation: An insight into myogenesis and osteogenesis.
Ramazzotti G, Faenza I, Fiume R, Billi AM, Manzoli L, Mongiorgi S, Ratti S, McCubrey JA, Suh PG, Cocco L, Follo MY. | 11/18/2017 |
| Unpredictable chronic mild stress mice exhibited lower nucleus accumbens (NAC) shell levels of phospholipase Cbeta. | Homer2 regulates alcohol and stress cross-sensitization.
Quadir SG, Santos JR, Campbell RR, Wroten MG, Singh N, Holloway JJ, Bal SK, Camarini R, Szumlinski KK., Free PMC Article | 01/14/2017 |
| Heightened PLCbeta1b activity observed in diseased myocardium contributes to pathology by PKCalpha-mediated contractile dysfunction. | The atypical 'b' splice variant of phospholipase Cβ1 promotes cardiac contractile dysfunction.
Grubb DR, Crook B, Ma Y, Luo J, Qian HW, Gao XM, Kiriazis H, Du XJ, Gregorevic P, Woodcock EA. | 04/9/2016 |
| inhibition of miR-214 in C2C12 cells significantly enhances the protein level of PLCbeta1 and promotes C2C12 BMP-2-induced osteogenesis by targeting PLCbeta1 | BMP-2 Induced Expression of PLCβ1 That is a Positive Regulator of Osteoblast Differentiation.
Ramazzotti G, Bavelloni A, Blalock W, Piazzi M, Cocco L, Faenza I. | 03/26/2016 |
| Results indicate that PLC-beta1 signalling in the medial prefrontal cortex is required for working memory | Knockdown of phospholipase C-β1 in the medial prefrontal cortex of male mice impairs working memory among multiple schizophrenia endophenotypes.
Kim SW, Seo M, Kim DS, Kang M, Kim YS, Koh HY, Shin HS., Free PMC Article | 08/15/2015 |
| In pro-B-lymphoblastic cells (Ba/F3), treated with H2O2, PI-PLCbeta1b conferred resistance to cell death, promoting cell cycle progression and cell proliferation and influencing the expression of cyclin A and E. | PI-PLCβ1b affects Akt activation, cyclin E expression, and caspase cleavage, promoting cell survival in pro-B-lymphoblastic cells exposed to oxidative stress.
Piazzi M, Blalock WL, Bavelloni A, Faenza I, Raffini M, Tagliavini F, Manzoli L, Cocco L. | 06/27/2015 |
| Tnis study demonistrated that plc beta1 distribuate in mice cerebellum. | Differential distribution of phospholipase C beta isoforms and diaglycerol kinase-beta in rodents cerebella corroborates the division of unipolar brush cells into two major subtypes.
Sekerková G, Watanabe M, Martina M, Mugnaini E., Free PMC Article | 10/18/2014 |
| Described is the interaction of nuclear PI-PLCbeta1b with a number of proteins involved in nuclear import, differentiation, mRNA processing, and apoptosis, thereby hinting at novel targets for therapeutic intervention in hematological malignancies. | Phosphoinositide-specific phospholipase C β 1b (PI-PLCβ1b) interactome: affinity purification-mass spectrometry analysis of PI-PLCβ1b with nuclear protein.
Piazzi M, Blalock WL, Bavelloni A, Faenza I, D'Angelo A, Maraldi NM, Cocco L., Free PMC Article | 03/25/2014 |
| PLCbeta coupling to D1 dopamine receptor regulates forward locomotion. | D1 dopamine receptor coupling to PLCβ regulates forward locomotion in mice.
Medvedev IO, Ramsey AJ, Masoud ST, Bermejo MK, Urs N, Sotnikova TD, Beaulieu JM, Gainetdinov RR, Salahpour A., Free PMC Article | 01/11/2014 |
| Defective PLCbeta1-mediated signalling during implantation is associated with the implantation failure, aberrant ovarian steroid signalling and endocannabinoid metabolism. | Implantation failure in mice with a disruption in Phospholipase C beta 1 gene: lack of embryonic attachment, aberrant steroid hormone signalling and defective endocannabinoid metabolism.
Filis P, Kind PC, Spears N., Free PMC Article | 11/2/2013 |
| Galphaq-coupled Lpar1 regulates cell proliferation and migration by activating two distinct PLC-beta isozymes, PLC-beta1 and PLC-beta2, respectively. | Distinct phospholipase C-β isozymes mediate lysophosphatidic acid receptor 1 effects on intestinal epithelial homeostasis and wound closure.
Lee SJ, Leoni G, Neumann PA, Chun J, Nusrat A, Yun CC., Free PMC Article | 06/22/2013 |
| These findings highlight a novel pathway by which nuclear PLCs affect insulin secretion and identify PPARgamma as a novel molecular target of nuclear PLCs. | Nuclear PLCs affect insulin secretion by targeting PPARγ in pancreatic β cells.
Fiume R, Ramazzotti G, Faenza I, Piazzi M, Bavelloni A, Billi AM, Cocco L. | 03/3/2012 |
| Demonstrate critical role of the glutamatergic system in the phenotype of the PLC-beta1 knockout mouse and highlight the role of these interconnected signalling pathways in schizophrenia-like behavioural disruption. | Sensitivity to MK-801 in phospholipase C-β1 knockout mice reveals a specific NMDA receptor deficit.
Gray L, McOmish CE, Scarr E, Dean B, Hannan AJ. | 09/10/2011 |
| Dilated atria from human and mouse showed heightened expression of PLCbeta1b. | Selective activation of the "b" splice variant of phospholipase Cbeta1 in chronically dilated human and mouse atria.
Woodcock EA, Grubb DR, Filtz TM, Marasco S, Luo J, McLeod-Dryden TJ, Kaye DM, Sadoshima J, Du XJ, Wong C, McMullen JR, Dart AM. | 01/21/2010 |
| PLCbeta1 localization is a key factor that determines progressive aquisition of meiotic competence and meiosis during folliculogenesis. | The role of PLC beta 1 in the control of oocyte meiosis during folliculogenesis.
Pesty A, Broca O, Poirot C, Lefèvre B. | 01/21/2010 |
| thrombin-induced signaling via protease-activated receptor-1, phospholipase-Cbeta, phosphoinositide 3-kinase, and nitric oxide in monocytes impairs monocyte transendothelial migration | Hypercoagulability inhibits monocyte transendothelial migration through protease-activated receptor-1-, phospholipase-Cbeta-, phosphoinositide 3-kinase-, and nitric oxide-dependent signaling in monocytes and promotes plaque stability.
Seehaus S, Shahzad K, Kashif M, Vinnikov IA, Schiller M, Wang H, Madhusudhan T, Eckstein V, Bierhaus A, Bea F, Blessing E, Weiler H, Frommhold D, Nawroth PP, Isermann B. | 01/21/2010 |
| desensitization of inward cationic current following carbachol in murine gastric myocytes is not due to a pathway dependent on intracellular Ca2+ but to the PLC beta1 pathway. | Involvement of the phospholipase C beta1 pathway in desensitization of the carbachol-activated nonselective cationic current in murine gastric myocytes.
Kim BJ, So I, Kim KW. | 01/21/2010 |