|
| Status |
Public on Sep 01, 2009 |
| Title |
Gene expression profiling of Stat3flx/flx/NIC breast tumors compared to wild type NIC tumors. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
A Stat3-dependent transcription regulatory network involved in inflammation and metastasis is identified.
Analyses of the gene expression data revealed that Stat3flx/flx/NIC tumors exhibited a significant reduction in the expression of factors involved in both tumor angiogenesis (fibronectin, von willebrand factor, annexin a3, thrombopoietin, fibulin 5) and in the acute phase inflammatory response (cebpd, osmr, saa1, saa2)
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| |
|
| Overall design |
Common reference design. 8 samples including RNA extracted from 3 pools of Stat3wt/wt/NIC (WT) tumor tissues (5 individual tumor samples per pool) and 5 individual Stat3flx/flx/NIC (Homo) tumor tissue samples.
|
| |
|
| Contributor(s) |
Ranger JJ, Levy DE, Shahalizadeh S, Hallett MT, Muller WJ |
| Citation(s) |
19690134 |
| |
| Submission date |
Apr 10, 2009 |
| Last update date |
May 10, 2018 |
| Contact name |
Solmaz Shahalizadeh |
| E-mail(s) |
solmaz@mcb.mcgill.ca
|
| Phone |
1-514-398-7071 00719
|
| Fax |
1-514-398-3387
|
| URL |
http://www.mcgill.ca/mcb/
|
| Organization name |
McGill University
|
| Department |
McGill Centre for Bioinformatics
|
| Lab |
Michael Hallett
|
| Street address |
3649 Prom. Sir-William-Osler, Room 435
|
| City |
Montreal |
| State/province |
Quebec |
| ZIP/Postal code |
H3G 0B1 |
| Country |
Canada |
| |
|
| Platforms (1) |
| GPL4134 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Feature Number version) |
|
| Samples (8)
|
|
| Relations |
| BioProject |
PRJNA115629 |
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