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| Status |
Public on Jun 02, 2021 |
| Title |
CXCR2 may serve as a useful index of disease activity in interstitial lung disease associated with primary Sjögren’s syndrome |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Primary Sjögren’s syndrome (pSS) is a chronic systemic autoimmune disease characterized by typical autoantibody production and lymphocytic-mediated exocrine gland damage. Interstitial lung disease (ILD) is a common complication of pSS and can be associated with a poor prognosis. However, the pathogenesis of ILD in pSS is still unclear. In this study, we used RNA sequencing to investigate the gene-expression profile of the minor salivary glands (MSGs) from 36 patients with ILD-pSS and 128 patients with non-ILD-pSS. In the remarkably enriched chemokine-mediated signaling pathway, CXCR2 was found to be significantly elevated in both MSG and plasma from pSS patients with versus without ILD (p < 0.001). Furthermore, the CXCR2 expression level in MSG and plasma was significantly associated with the diffusing capacity of the lungs for carbon monoxide, erythrocyte sedimentation rate, and EULAR Sjögren’s Syndrome Disease Activity Index in ILD-pSS. Therefore, with its potential role in ILD progression in patients with pSS and its strong association with clinical manifestations of the disease, CXCR2 may serve as a useful index for disease activity in ILD associated with pSS.
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| Overall design |
**The submitter states that the 'disease state' characteristic and fastq files for some of the Samples might by inaccurate. Corrections are in progress. [Dec 06, 2022]**
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| Contributor(s) |
Zhu X, Lu S, Zhu L, Yu M, Wei T, Zhu X, Chen D, Chen C |
| Citation(s) |
34055876 |
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| Submission date |
Apr 12, 2021 |
| Last update date |
Dec 09, 2022 |
| Contact name |
Xiaofang Zhu |
| E-mail(s) |
june8587@outlook.com
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| Phone |
86+13758484680
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| Organization name |
First Affiliated Hospital of Wenzhou Medical University
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| Department |
Rheumatology
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| Street address |
Nan Bai Xiang Street
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| City |
Wenzhou |
| State/province |
Zhejiang Province |
| ZIP/Postal code |
325000 |
| Country |
China |
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| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
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| Samples (164)
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| Relations |
| BioProject |
PRJNA721374 |
| SRA |
SRP314460 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE171896_Sample_normalized_counts_matrix.txt.gz |
27.6 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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