 |
 |
GEO help: Mouse over screen elements for information. |
|
| Status |
Public on Aug 30, 2014 |
| Title |
Gene expression changes in limb buds of Nipbl-haploinsufficient mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Multiple genes are dysregulated in hindlimb buds of Nipbl-deficient embryos. In all, more than 1000 limb bud genes were found to be significantly altered in expression by microarray analysis of E10.5 mouse hindlimb buds.
Small changes in expression (mostly decreases) were observed for genes involved in FGF, BMP, and SHH pathways, as well as numerous genes involved in the Wnt/planar cell polarity signaling pathway. Genes involved in the Mediator complex, Cohesin function, and Hox gene expression and functions were also dysregulated in Nipbl deficient limb buds.
|
| |
|
| Overall design |
Microarray analysis using RNA extracted from E10.5 hindlimb limb buds harvested from stage-matched Nipbl+/- (n=12) and wildtype (n=12)
|
| |
|
| Contributor(s) |
Lopez-Burks ME, Lander AD |
| Citation(s) |
25255084 |
| |
| Submission date |
Aug 29, 2014 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Arthur D Lander |
| Organization name |
University of California Irvine
|
| Department |
Developmental and Cell Biology
|
| Lab |
Center for Complex Biological Systems
|
| Street address |
2638 Biosciences 3
|
| City |
Irvine |
| State/province |
CA |
| ZIP/Postal code |
92697 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
|
| Samples (24)
|
| GSM1493862 |
wildtype E10.5 hindlimb buds, biological rep1 |
| GSM1493863 |
wildtype E10.5 hindlimb buds, biological rep2 |
| GSM1493864 |
wildtype E10.5 hindlimb buds, biological rep3 |
| GSM1493865 |
wildtype E10.5 hindlimb buds, biological rep4 |
| GSM1493866 |
wildtype E10.5 hindlimb buds, biological rep5 |
| GSM1493867 |
wildtype E10.5 hindlimb buds, biological rep6 |
| GSM1493868 |
wildtype E10.5 hindlimb buds, biological rep7 |
| GSM1493869 |
wildtype E10.5 hindlimb buds, biological rep8 |
| GSM1493870 |
wildtype E10.5 hindlimb buds, biological rep9 |
| GSM1493871 |
wildtype E10.5 hindlimb buds, biological rep10 |
| GSM1493872 |
wildtype E10.5 hindlimb buds, biological rep11 |
| GSM1493873 |
wildtype E10.5 hindlimb buds, biological rep12 |
| GSM1493874 |
Nipbl heterozygous E10.5 hindlimb buds, biological rep1 |
| GSM1493875 |
Nipbl heterozygous E10.5 hindlimb buds, biological rep2 |
| GSM1493876 |
Nipbl heterozygous E10.5 hindlimb buds, biological rep3 |
| GSM1493877 |
Nipbl heterozygous E10.5 hindlimb buds, biological rep4 |
| GSM1493878 |
Nipbl heterozygous E10.5 hindlimb buds, biological rep5 |
| GSM1493879 |
Nipbl heterozygous E10.5 hindlimb buds, biological rep6 |
| GSM1493880 |
Nipbl heterozygous E10.5 hindlimb buds, biological rep7 |
| GSM1493881 |
Nipbl heterozygous E10.5 hindlimb buds, biological rep8 |
| GSM1493882 |
Nipbl heterozygous E10.5 hindlimb buds, biological rep9 |
| GSM1493883 |
Nipbl heterozygous E10.5 hindlimb buds, biological rep10 |
| GSM1493884 |
Nipbl heterozygous E10.5 hindlimb buds, biological rep11 |
| GSM1493885 |
Nipbl heterozygous E10.5 hindlimb buds, biological rep12 |
|
| Relations |
| BioProject |
PRJNA259854 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE60932_RAW.tar |
104.4 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
|
|
|
|
 |
Less...
More...