Lanosterol - MeSH

Select item 680078101.

A triterpene that derives from the chair-boat-chair-boat folding of 2,3-oxidosqualene. It is metabolized to CHOLESTEROL and CUCURBITACINS.

Year introduced: 1974(1972)

Select item 670219242.

lanosterol synthase [Supplementary Concept]

Date introduced: January 1, 1976

Select item 680588863.

Sterol 14-Demethylase

An NADPH-dependent P450 enzyme that plays an essential role in the sterol biosynthetic pathway by catalyzing the demethylation of 14-methyl sterols such as lanosterol. The enzyme acts via the repeated hydroxylation of the 14-methyl group, resulting in its stepwise conversion into an alcohol, an aldehyde and then a carboxylate, which is removed as formic acid. Sterol 14-demethylase is an unusual cytochrome P450 enzyme in that it is found in a broad variety of organisms including ANIMALS; PLANTS; FUNGI; and protozoa.

Year introduced: 2011

Select item 680588884.

14-alpha Demethylase Inhibitors

Compounds that specifically inhibit STEROL 14-DEMETHYLASE. A variety of azole-derived ANTIFUNGAL AGENTS act through this mechanism.

Year introduced: 2011

Select item 675484185.

CYP51A1 protein, human [Supplementary Concept]

RefSeq NM_000786

Date introduced: June 25, 2010

Select item 675263486.

Erg11 protein, S cerevisiae [Supplementary Concept]

GenBank M18109