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Presenilin-1
Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN1 mutations cause early-onset ALZHEIMER DISEASE type 3 that may occur as early as 30 years of age in humans.
Year introduced: 2007
PSEN1 protein, human [Supplementary Concept]
RefSeq NM_000021
Date introduced: August 4, 2006
MTCH1 protein, human [Supplementary Concept]
RefSeq NM_014341
Date introduced: December 28, 1999
TPIP (protein) [Supplementary Concept]
do not confuse with TPTE2 which is also known as TPIP
Date introduced: October 15, 1999
Psen1 protein, rat [Supplementary Concept]
Date introduced: May 22, 2016
presenilin 1, mouse [Supplementary Concept]
RefSeq NM_008943
Date introduced: April 30, 2013
Psen1 protein, zebrafish [Supplementary Concept]
RefSeq NM_131024
Date introduced: September 28, 2009