FIGURE 3

Effects of prior FOLFOX chemotherapy treatment on skeletal muscle myokine/exerkine gene expression following repeated long-duration exercise bouts. Red gastrocnemius expression of (A) IL-6, (B) LIF, (C) myostatin, (D) brain-derived neurotrophic factor (BDNF), (E) IL-15, and (F) irisin mRNA in PBS and FOLFOX sedentary and long-duration exercise trained mice. GAPDH was used as the housekeeping gene. 0 min/d: PBS N = 13, FOLFOX N = 12, 55 min/d: PBS N = 10, FOLFOX N = 10. Data is presented as mean ± SEM. Data is analyzed using Two-Way ANOVA. Statistical significance was set to p < 0.05. Bold and italicized values are significant. # main effect of FOLFOX, $ main effect of 55 min/d (long-duration) exercise.