Fig. 2

Methylation of cg16447589 is associated with IGFBP3 concentrations in plasma and prenatal arsenic exposure. a Methylation of cg16447589 is negatively associated with IGFBP3 concentrations in plasma in boys and positively associated in girls. b Prenatal exposure to As, expressed as natural log-transformed maternal arsenic in urine in gestational week 8 [ln(As in urine GW 8)], is negatively associated with methylation of cg16447589 in boys and positively associated in girls. Lines indicate the regression line, and the shadows represent the 95% confidence interval