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Published online 2021 Oct 14. doi: 10.1016/j.xinn.2021.100174
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Figure 8

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DNA nanodevice-based vaccine for cancer metastasis immunotherapy

(A) Schematic illustration of the construction of the tumor antigen peptide/CpG loop/dsRNA-co-loaded robotic nanostructure by DNA origami. Images of the DNA origami rectangles with capture strands, robotic structures in the open state, and robotic structures in the locked state are shown. Scale bars, 200 nm.

(B) Utilization of the DNA nanodevices for efficient cancer immunotherapy.

(C) Mice were intravenously inoculated with B16-OVA tumor cells on day 0 and immunized on days 1 and 7 with the DNA nanodevice vaccine or given control formulations. The lungs were harvested on day 18 post-inoculation and imaged to count the metastatic nodules.

(D) H&E staining of lungs collected from the treated mice. Scale bars, 3 mm.

Reproduced with permission from Liu et al.134 Copyright 2021, Nature Publishing Group.

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