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Volume 101(13);  2004 Mar 30

Commentaries

Closing the gaps in kinetoplast DNA network replication
Michele M. Klingbeil, Paul T. Englund
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4333–4334. Published online 2004 Mar 22. doi: 10.1073/pnas.0401400101
PMCID:
PMC384744
Article PDF–288K
Unzipping the mysteries of amyloid fiber formation
Andrew D. Miranker
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4335–4336. Published online 2004 Mar 22. doi: 10.1073/pnas.0401163101
PMCID:
PMC384745
Article PDF–115K
Extending molecular modeling methodology to study insertion of membrane nanopores
Aleksij Aksimentiev, Klaus Schulten
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4337–4338. Published online 2004 Mar 22. doi: 10.1073/pnas.0400739101
PMCID:
PMC384746
Article PDF–324K
Unraveling the mystery of Nod factor signaling by a genomic approach in Medicago trunactula
Douglas R. Cook
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4339–4340. Published online 2004 Mar 22. doi: 10.1073/pnas.0400961101
PMCID:
PMC384747
Article PDF–116K

Physical Sciences

Applied Mathematics

Response of complex networks to stimuli
Yaneer Bar-Yam, Irving R. Epstein
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4341–4345. Published online 2004 Mar 18. doi: 10.1073/pnas.0400673101
PMCID:
PMC384748
Abstract Article PDF–338K

Chemistry

The structure of zetekitoxin AB, a saxitoxin analog from the Panamanian golden frog Atelopus zeteki: A potent sodium-channel blocker
Mari Yotsu-Yamashita, Yong H. Kim, Samuel C. Dudley, Jr., Gaurav Choudhary, Arnold Pfahnl, Yasukatsu Oshima, John W. Daly
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4346–4351. Published online 2004 Mar 22. doi: 10.1073/pnas.0400368101
PMCID:
PMC384749
Abstract Article PDF–503K

Mathematics

The strong Nagata conjecture
Ualbai U. Umirbaev, Jie-Tai Yu
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4352–4355. Published online 2004 Mar 16. doi: 10.1073/pnas.0308157101
PMCID:
PMC384750
Abstract Article PDF–213K

Biological Sciences

Anthropology

Morphometrics and hominoid phylogeny: Support for a chimpanzee–human clade and differentiation among great ape subspecies
Charles A. Lockwood, William H. Kimbel, John M. Lynch
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4356–4360. Published online 2004 Mar 22. doi: 10.1073/pnas.0306235101
PMCID:
PMC384751
Abstract Article PDF–355K

Biochemistry

Mitochondrial DNA ligase in Crithidia fasciculata
Krishna Murari Sinha, Jane C. Hines, Nicholas Downey, Dan S. Ray
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4361–4366. Published online 2004 Mar 2. doi: 10.1073/pnas.0305705101
PMCID:
PMC384752
Abstract Article PDF–476K
Molecular clamp mechanism of substrate binding by hydrophobic coiled-coil residues of the archaeal chaperone prefoldin
Victor F. Lundin, Peter C. Stirling, Juan Gomez-Reino, Jill C. Mwenifumbo, Jennifer M. Obst, José M. Valpuesta, Michel R. Leroux
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4367–4372. Published online 2004 Mar 19. doi: 10.1073/pnas.0306276101
PMCID:
PMC384753
Abstract Article PDF–539K
The arginine finger of bacteriophage T7 gene 4 helicase: Role in energy coupling
Donald J. Crampton, Shenyuan Guo, Donald E. Johnson, Charles C. Richardson
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4373–4378. doi: 10.1073/pnas.0400968101
PMCID:
PMC384754
Abstract Article PDF–405K
Purification and architecture of the ubiquitous Wave complex
Alexis Gautreau, Hsin-yi H. Ho, Jiaxu Li, Hanno Steen, Steven P. Gygi, Marc W. Kirschner
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4379–4383. Published online 2004 Mar 19. doi: 10.1073/pnas.0400628101
PMCID:
PMC384755
Abstract Article PDF–406K
Gene disruption confirms a critical role for the cysteine protease falcipain-2 in hemoglobin hydrolysis by Plasmodium falciparum
Puran S. Sijwali, Philip J. Rosenthal
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4384–4389. Published online 2004 Mar 15. doi: 10.1073/pnas.0307720101
PMCID:
PMC384756
Abstract Article PDF–517K
Characterization of a regiospecific epivancosaminyl transferase GtfA and enzymatic reconstitution of the antibiotic chloroeremomycin
Wei Lu, Markus Oberthür, Catherine Leimkuhler, Junhua Tao, Daniel Kahne, Christopher T. Walsh
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4390–4395. Published online 2004 Mar 18. doi: 10.1073/pnas.0400277101
PMCID:
PMC384757
Abstract Article PDF–511K
The role of RNA polymerase σ subunit in promoter-independent initiation of transcription
Nikolay Zenkin, Konstantin Severinov
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4396–4400. Published online 2004 Mar 15. doi: 10.1073/pnas.0400886101
PMCID:
PMC384758
Abstract Article PDF–369K
Functional association between Wwox tumor suppressor protein and p73, a p53 homolog
Rami I. Aqeilan, Yuri Pekarsky, Juan J. Herrero, Alexey Palamarchuk, Jean Letofsky, Teresa Druck, Francesco Trapasso, Shuang-Yin Han, Gerry Melino, Kay Huebner, Carlo M. Croce
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4401–4406. doi: 10.1073/pnas.0400805101
PMCID:
PMC384759
Abstract Article PDF–510K
Mammalian GLD-2 homologs are poly(A) polymerases
Jae Eun Kwak, Liaoteng Wang, Scott Ballantyne, Judith Kimble, Marvin Wickens
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4407–4412. doi: 10.1073/pnas.0400779101
PMCID:
PMC384760
Abstract Article PDF–638K
Isoprenoid biosynthesis in the diatoms Rhizosolenia setigera (Brightwell) and Haslea ostrearia (Simonsen)
Guillaume Massé, Simon T. Belt, Steven J. Rowland, Michel Rohmer
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4413–4418. Published online 2004 Mar 22. doi: 10.1073/pnas.0400902101
PMCID:
PMC384761
Abstract Article PDF–353K
M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFβ-TrCP
Nobumoto Watanabe, Harumi Arai, Yoshifumi Nishihara, Makoto Taniguchi, Naoko Watanabe, Tony Hunter, Hiroyuki Osada
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4419–4424. Published online 2004 Mar 22. doi: 10.1073/pnas.0307700101
PMCID:
PMC384762
Abstract Article PDF–526K

Biophysics

The structure of the RNA-dependent RNA polymerase from bovine viral diarrhea virus establishes the role of GTP in de novo initiation
Kyung H. Choi, James M. Groarke, Dorothy C. Young, Richard J. Kuhn, Janet L. Smith, Daniel C. Pevear, Michael G. Rossmann
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4425–4430. Published online 2004 Mar 19. doi: 10.1073/pnas.0400660101
PMCID:
PMC384763
Abstract Article PDF–658K
Understanding nature's design for a nanosyringe
Carlos F. Lopez, Steve O. Nielsen, Preston B. Moore, Michael L. Klein
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4431–4434. Published online 2004 Mar 12. doi: 10.1073/pnas.0400352101
PMCID:
PMC384764
Abstract Article PDF–584K
Exploring amyloid formation by a de novo design
Richard A. Kammerer, Dirk Kostrewa, Jesús Zurdo, Andreas Detken, Carlos García-Echeverría, Janelle D. Green, Shirley A. Müller, Beat H. Meier, Fritz K. Winkler, Christopher M. Dobson, Michel O. Steinmetz
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4435–4440. Published online 2004 Feb 26. doi: 10.1073/pnas.0306786101
PMCID:
PMC384765
Abstract Article PDF–523K
Evolving potassium channels by means of yeast selection reveals structural elements important for selectivity
Delphine Bichet, Yu-Fung Lin, Christian A. Ibarra, Cindy Shen Huang, B. Alexander Yi, Yuh Nung Jan, Lily Yeh Jan
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4441–4446. Published online 2004 Mar 22. doi: 10.1073/pnas.0401195101
PMCID:
PMC384766
Abstract Article PDF–601K
Percolation and criticality in a mitochondrial network
Miguel A. Aon, Sonia Cortassa, Brian O'Rourke
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4447–4452. Published online 2004 Mar 18. doi: 10.1073/pnas.0307156101
PMCID:
PMC384767
Abstract Article PDF–855K

Cell Biology

Partially redundant functions of SRC-1 and TIF2 in postnatal survival and male reproduction
Manuel Mark, Hiromi Yoshida-Komiya, Martine Gehin, Lan Liao, Ming-Jer Tsai, Bert W. O'Malley, Pierre Chambon, Jianming Xu
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4453–4458. doi: 10.1073/pnas.0400234101
PMCID:
PMC384768
Abstract Article PDF–663K
Complete loss of the tumor suppressor MAD2 causes premature cyclin B degradation and mitotic failure in human somatic cells
Loren Michel, Elena Diaz-Rodriguez, Gopeshwar Narayan, Eva Hernando, Vundavalli V. V. S. Murty, Robert Benezra
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4459–4464. Published online 2004 Mar 15. doi: 10.1073/pnas.0306069101
PMCID:
PMC384769
Abstract Article PDF–659K
Regulation of cyclin-dependent kinase activity during mitotic exit and maintenance of genome stability by p21, p27, and p107
Taku Chibazakura, Seth G. McGrew, Jonathan A. Cooper, Hirofumi Yoshikawa, James M. Roberts
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4465–4470. Published online 2004 Mar 15. doi: 10.1073/pnas.0400655101
PMCID:
PMC384770
Abstract Article PDF–572K
A transgenic mouse model of metastatic carcinoma involving transdifferentiation of a gastric epithelial lineage progenitor to a neuroendocrine phenotype
Andrew J. Syder, Sherif M. Karam, Jason C. Mills, Joseph E. Ippolito, Habib R. Ansari, Vidya Farook, Jeffrey I. Gordon
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4471–4476. doi: 10.1073/pnas.0307983101
PMCID:
PMC384771
Abstract Article PDF–566K
Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair
Chang-Goo Huh, Valentina M. Factor, Aránzazu Sánchez, Koichi Uchida, Elizabeth A. Conner, Snorri S. Thorgeirsson
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4477–4482. doi: 10.1073/pnas.0306068101
PMCID:
PMC384772
Abstract Article PDF–1017K
Caenorhabditis elegans functional orthologue of human protein h-mucolipin-1 is required for lysosome biogenesis
Sebastian Treusch, Sarah Knuth, Susan A. Slaugenhaupt, Ehud Goldin, Barth D. Grant, Hanna Fares
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4483–4488. Published online 2004 Mar 15. doi: 10.1073/pnas.0400709101
PMCID:
PMC384773
Abstract Article PDF–566K

Developmental Biology

Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling
Wei Liu, Jennifer Selever, Degang Wang, Mei-Fang Lu, Kelvin A. Moses, Robert J. Schwartz, James F. Martin
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4489–4494. Published online 2004 Mar 19. doi: 10.1073/pnas.0308466101
PMCID:
PMC384774
Abstract Article PDF–769K
Self-renewal capacity is a widespread property of various types of neural crest precursor cells
Andréa Trentin, Corinne Glavieux-Pardanaud, Nicole M. Le Douarin, Elisabeth Dupin
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4495–4500. Published online 2004 Mar 15. doi: 10.1073/pnas.0400629101
PMCID:
PMC384775
Abstract Article PDF–484K

Ecology

The ecological and evolutionary consequences of sperm chemoattraction
Jeffrey A. Riffell, Patrick J. Krug, Richard K. Zimmer
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4501–4506. Published online 2004 Mar 22. doi: 10.1073/pnas.0304594101
PMCID:
PMC384776
Abstract Article PDF–551K

Evolution

Body plan evolution of ascomycetes, as inferred from an RNA polymerase II phylogeny
Yajuan J. Liu, Benjamin D. Hall
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4507–4512. Published online 2004 Mar 19. doi: 10.1073/pnas.0400938101
PMCID:
PMC384777
Abstract Article PDF–1.0M
Evolutionary stability of DNA uptake signal sequences in the Pasteurellaceae
M. Bakkali, T.-Y. Chen, H. C. Lee, R. J. Redfield
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4513–4518. Published online 2004 Mar 19. doi: 10.1073/pnas.0306366101
PMCID:
PMC384778
Abstract Article PDF–315K

Genetics

Tying synaptonemal complex initiation to the formation and programmed repair of DNA double-strand breaks
Kiersten A. Henderson, Scott Keeney
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4519–4524. Published online 2004 Mar 18. doi: 10.1073/pnas.0400843101
PMCID:
PMC384779
Abstract Article PDF–552K
Yeast genome-wide drug-induced haploinsufficiency screen to determine drug mode of action
Kristin Baetz, Lianne McHardy, Ken Gable, Tamsin Tarling, Delphine Rebérioux, Jenny Bryan, Raymond J. Andersen, Teresa Dunn, Phil Hieter, Michel Roberge
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4525–4530. Published online 2004 Mar 15. doi: 10.1073/pnas.0307122101
PMCID:
PMC384780
Abstract Article PDF–456K
Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults
Julio Licinio, Sinan Caglayan, Metin Ozata, Bulent O. Yildiz, Patricia B. de Miranda, Fiona O'Kirwan, Robert Whitby, Liyin Liang, Pinchas Cohen, Shalender Bhasin, Ronald M. Krauss, Johannes D. Veldhuis, Anthony J. Wagner, Alex M. DePaoli, Samuel M. McCann, Ma-Li Wong
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4531–4536. Published online 2004 Mar 9. doi: 10.1073/pnas.0308767101
PMCID:
PMC384781
Abstract Article PDF–544K
Genome-wide identification of DNaseI hypersensitive sites using active chromatin sequence libraries
Peter J. Sabo, Richard Humbert, Michael Hawrylycz, James C. Wallace, Michael O. Dorschner, Michael McArthur, John A. Stamatoyannopoulos
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4537–4542. Published online 2004 Mar 19. doi: 10.1073/pnas.0400678101
PMCID:
PMC384782
Abstract Article PDF–432K
Peroxisome proliferator-activated receptor γ is required in mature white and brown adipocytes for their survival in the mouse
Takeshi Imai, Reiko Takakuwa, Sandra Marchand, Emilie Dentz, Jean-Marc Bornert, Nadia Messaddeq, Olivia Wendling, Manuel Mark, Béatrice Desvergne, Walter Wahli, Pierre Chambon, Daniel Metzger
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4543–4547. Published online 2004 Mar 16. doi: 10.1073/pnas.0400356101
PMCID:
PMC384783
Abstract Article PDF–793K
Circle-to-circle amplification for precise and sensitive DNA analysis
Fredrik Dahl, Johan Banér, Mats Gullberg, Maritha Mendel-Hartvig, Ulf Landegren, Mats Nilsson
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4548–4553. Published online 2004 Mar 15. doi: 10.1073/pnas.0400834101
PMCID:
PMC384784
Abstract Article PDF–518K
A regulator that inhibits transcription by targeting an intersubunit interaction of the RNA polymerase holoenzyme
B. D. Gregory, B. E. Nickels, S. J. Garrity, E. Severinova, L. Minakhin, R. J. Bieber Urbauer, J. L. Urbauer, T. Heyduk, K. Severinov, A. Hochschild
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4554–4559. Published online 2004 Mar 22. doi: 10.1073/pnas.0400923101
PMCID:
PMC384785
Abstract Article PDF–425K

Immunology

Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria
Frank A. W. Verreck, Tjitske de Boer, Dennis M. L. Langenberg, Marieke A. Hoeve, Matthijs Kramer, Elena Vaisberg, Robert Kastelein, Arend Kolk, René de Waal-Malefyt, Tom H. M. Ottenhoff
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4560–4565. Published online 2004 Mar 19. doi: 10.1073/pnas.0400983101
PMCID:
PMC384786
Abstract Article PDF–524K
Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-κB activation
Marc Schmidt-Supprian, Jane Tian, Ethan P. Grant, Manolis Pasparakis, René Maehr, Huib Ovaa, Hidde L. Ploegh, Anthony J. Coyle, Klaus Rajewsky
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4566–4571. Published online 2004 Mar 16. doi: 10.1073/pnas.0400885101
PMCID:
PMC384787
Abstract Article PDF–477K
TGF-β regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes
Yufeng Peng, Yasmina Laouar, Ming O. Li, E. Allison Green, Richard A. Flavell
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4572–4577. Published online 2004 Mar 18. doi: 10.1073/pnas.0400810101
PMCID:
PMC384788
Abstract Article PDF–588K

Medical Sciences

Role of NADPH oxidase in arsenic-induced reactive oxygen species formation and cytotoxicity in myeloid leukemia cells
Wen-Chien Chou, Chunfa Jie, Andrew A. Kenedy, Richard J. Jones, Michael A. Trush, Chi V. Dang
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4578–4583. Published online 2004 Mar 15. doi: 10.1073/pnas.0306687101
PMCID:
PMC384789
Abstract Article PDF–684K
A zebrafish model for pyruvate dehydrogenase deficiency: Rescue of neurological dysfunction and embryonic lethality using a ketogenic diet
Michael R. Taylor, James B. Hurley, Heather A. Van Epps, Susan E. Brockerhoff
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4584–4589. Published online 2004 Mar 15. doi: 10.1073/pnas.0307074101
PMCID:
PMC384790
Abstract Article PDF–489K
Highly attenuated smallpox vaccine protects mice with and without immune deficiencies against pathogenic vaccinia virus challenge
Linda S. Wyatt, Patricia L. Earl, Leigh Anne Eller, Bernard Moss
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4590–4595. Published online 2004 Mar 11. doi: 10.1073/pnas.0401165101
PMCID:
PMC384791
Abstract Article PDF–465K

Microbiology

Gnotobiotic zebrafish reveal evolutionarily conserved responses to the gut microbiota
John F. Rawls, Buck S. Samuel, Jeffrey I. Gordon
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4596–4601. Published online 2004 Mar 19. doi: 10.1073/pnas.0400706101
PMCID:
PMC384792
Abstract Article PDF–544K
The temporal expression profile of Mycobacterium tuberculosis infection in mice
Adel M. Talaat, Rick Lyons, Susan T. Howard, Stephen Albert Johnston
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4602–4607. Published online 2004 Mar 18. doi: 10.1073/pnas.0306023101
PMCID:
PMC384793
Abstract Article PDF–419K
Mycobacterial polyketide-associated proteins are acyltransferases: Proof of principle with Mycobacterium tuberculosis PapA5
Kenolisa C. Onwueme, Julian A. Ferreras, John Buglino, Christopher D. Lima, Luis E. N. Quadri
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4608–4613. Published online 2004 Mar 18. doi: 10.1073/pnas.0306928101
Correction in:
Proc Natl Acad Sci U S A. 2004 Apr 27; 101(17): 6834.
PMCID:
PMC384794
Abstract Article PDF–448K
Salmonella typhi encodes a functional cytolethal distending toxin that is delivered into host cells by a bacterial-internalization pathway
Erik Haghjoo, Jorge E. Galán
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4614–4619. doi: 10.1073/pnas.0400932101
PMCID:
PMC384795
Abstract Article PDF–707K
Human and avian influenza viruses target different cell types in cultures of human airway epithelium
Mikhail N. Matrosovich, Tatyana Y. Matrosovich, Thomas Gray, Noel A. Roberts, Hans-Dieter Klenk
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4620–4624. Published online 2004 Mar 15. doi: 10.1073/pnas.0308001101
PMCID:
PMC384796
Abstract Article PDF–644K
Inhibition of Epstein-Barr virus-induced growth proliferation by a nuclear antigen EBNA2-TAT peptide
Christopher J. Farrell, Jae Myun Lee, Eui-Cheol Shin, Marek Cebrat, Philip A. Cole, S. Diane Hayward
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4625–4630. Published online 2004 Mar 19. doi: 10.1073/pnas.0306482101
Correction in:
Proc Natl Acad Sci U S A. 2004 Sep 14; 101(37): 13694.
PMCID:
PMC384797
Abstract Article PDF–431K
Temperature dependence of metabolic rates for microbial growth, maintenance, and survival
P. Buford Price, Todd Sowers
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4631–4636. doi: 10.1073/pnas.0400522101
PMCID:
PMC384798
Abstract Article PDF–332K

Neuroscience

Default-mode network activity distinguishes Alzheimer's disease from healthy aging: Evidence from functional MRI
Michael D. Greicius, Gaurav Srivastava, Allan L. Reiss, Vinod Menon
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4637–4642. Published online 2004 Mar 15. doi: 10.1073/pnas.0308627101
PMCID:
PMC384799
Abstract Article PDF–541K
Proteomic mapping provides powerful insights into functional myelin biology
Christopher M. Taylor, Cecilia B. Marta, Robert J. Claycomb, David K. Han, Matthew N. Rasband, Timothy Coetzee, Steven E. Pfeiffer
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4643–4648. Published online 2004 Mar 19. doi: 10.1073/pnas.0400922101
PMCID:
PMC384800
Abstract Article PDF–451K
Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice
Michihiro Mieda, Jon T. Willie, Junko Hara, Christopher M. Sinton, Takeshi Sakurai, Masashi Yanagisawa
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4649–4654. Published online 2004 Mar 16. doi: 10.1073/pnas.0400590101
PMCID:
PMC384801
Abstract Article PDF–509K
Chaos may enhance information transmission in the inferior olive
Nicolas Schweighofer, Kenji Doya, Hidekazu Fukai, Jean Vianney Chiron, Tetsuya Furukawa, Mitsuo Kawato
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4655–4660. Published online 2004 Mar 22. doi: 10.1073/pnas.0305966101
PMCID:
PMC384802
Abstract Article PDF–373K
Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation
Qian Gao, Michael J. Wolfgang, Susanne Neschen, Katsutaro Morino, Tamas L. Horvath, Gerald I. Shulman, Xin-Yuan Fu
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4661–4666. Published online 2004 Mar 22. doi: 10.1073/pnas.0303992101
PMCID:
PMC384803
Abstract Article PDF–741K
Behavioral impairments caused by injections of the protein synthesis inhibitor anisomycin after contextual retrieval reverse with time
K. Matthew Lattal, Ted Abel
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4667–4672. Published online 2004 Mar 19. doi: 10.1073/pnas.0306546101
PMCID:
PMC384804
Abstract Article PDF–395K

Pharmacology

Quantitative analysis of the formation and diffusion of A1-adenosine receptor-antagonist complexes in single living cells
S. J. Briddon, R. J. Middleton, Y. Cordeaux, F. M. Flavin, J. A. Weinstein, M. W. George, B. Kellam, S. J. Hill
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4673–4678. Published online 2004 Mar 16. doi: 10.1073/pnas.0400420101
PMCID:
PMC384805
Abstract Article PDF–427K

Physiology

Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor
Yuxiang Sun, Pei Wang, Hui Zheng, Roy G. Smith
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4679–4684. Published online 2004 Mar 18. doi: 10.1073/pnas.0305930101
PMCID:
PMC384806
Abstract Article PDF–501K
Relaxin regulation of endometrial structure and function in the rhesus monkey
Laura T. Goldsmith, Gerson Weiss, Smita Palejwala, Tony M. Plant, Andrea Wojtczuk, W. Clark Lambert, Nael Ammur, Debra Heller, Joan H. Skurnick, Dean Edwards, Donna M. Cole
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4685–4689. Published online 2004 Mar 19. doi: 10.1073/pnas.0400776101
PMCID:
PMC384807
Abstract Article PDF–318K
Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins
Kozue Yamauchi, Tatemitsu Rai, Katsuki Kobayashi, Eisei Sohara, Tatsunori Suzuki, Tomohiro Itoh, Shin Suda, Atsushi Hayama, Sei Sasaki, Shinichi Uchida
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4690–4694. Published online 2004 Mar 19. doi: 10.1073/pnas.0306924101
PMCID:
PMC384808
Abstract Article PDF–480K
Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY3-36
B. G. Challis, A. P. Coll, G. S. H. Yeo, S. B. Pinnock, S. L. Dickson, R. R. Thresher, J. Dixon, D. Zahn, J. J. Rochford, A. White, R. L. Oliver, G. Millington, S. A. Aparicio, W. H. Colledge, A. P. Russ, M. B. Carlton, S. O'Rahilly
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4695–4700. Published online 2004 Mar 15. doi: 10.1073/pnas.0306931101
PMCID:
PMC384809
Abstract Article PDF–421K

Plant Biology

A Ca2+/calmodulin-dependent protein kinase required for symbiotic nodule development: Gene identification by transcript-based cloning
Raka M. Mitra, Cynthia A. Gleason, Anne Edwards, James Hadfield, J. Allan Downie, Giles E. D. Oldroyd, Sharon R. Long
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4701–4705. Published online 2004 Mar 1. doi: 10.1073/pnas.0400595101
PMCID:
PMC384810
Abstract Article PDF–422K
WIN1, a transcriptional activator of epidermal wax accumulation in Arabidopsis
Pierre Broun, Patricia Poindexter, Erin Osborne, Cai-Zhong Jiang, José Luis Riechmann
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4706–4711. Published online 2004 Mar 22. doi: 10.1073/pnas.0305574101
PMCID:
PMC384811
Abstract Article PDF–520K
A latitudinal cline in flowering time in Arabidopsis thaliana modulated by the flowering time gene FRIGIDA
John R. Stinchcombe, Cynthia Weinig, Mark Ungerer, Kenneth M. Olsen, Charlotte Mays, Solveig S. Halldorsdottir, Michael D. Purugganan, Johanna Schmitt
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4712–4717. Published online 2004 Mar 19. doi: 10.1073/pnas.0306401101
PMCID:
PMC384812
Abstract Article PDF–331K

Corrections

[No title available]
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4718. doi: 10.1073/pnas.0401128101
Corrects:
Proc Natl Acad Sci U S A. 2003 Dec 9; 100(25): 14737–14741.
PMCID:
PMC384813
Correction PDF–439K
[No title available]
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4718. doi: 10.1073/pnas.0400811101
Corrects:
Proc Natl Acad Sci U S A. 2004 Jan 13; 101(2): 458–463.
PMCID:
PMC384814
Correction PDF–439K
[No title available]
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4718. doi: 10.1073/pnas.0401134101
Corrects:
Proc Natl Acad Sci U S A. 2003 Oct 28; 100(22): 12543–12547.
PMCID:
PMC384815
Correction PDF–439K
[No title available]
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4718–4719. doi: 10.1073/pnas.0400841101
Corrects:
Proc Natl Acad Sci U S A. 2003 Oct 14; 100(21): 12283–12288.
PMCID:
PMC384816
Correction PDF–439K
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