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Volume 287(52);  2012 Dec 21

Minireview

Mammalian Target of Rapamycin (mTOR) Signaling Network in Skeletal Myogenesis
Yejing Ge, Jie Chen
J Biol Chem. 2012 Dec 21; 287(52): 43928–43935. Published online 2012 Oct 31. doi: 10.1074/jbc.R112.406942
PMCID:
PMC3527976
Abstract Article PDF–621K

Bioenergetics

Electrostatic Ratchet in the Protective Antigen Channel Promotes Anthrax Toxin Translocation
Sarah L. Wynia-Smith, Michael J. Brown, Gina Chirichella, Gigi Kemalyan, Bryan A. Krantz
J Biol Chem. 2012 Dec 21; 287(52): 43753–43764. Published online 2012 Oct 31. doi: 10.1074/jbc.M112.419598
PMCID:
PMC3527960
Abstract Article PDF–1.6M

Cell Biology

Structural and Functional Characterization of the Kindlin-1 Pleckstrin Homology Domain
Luke A. Yates, Craig N. Lumb, Nina N. Brahme, Ruta Zalyte, Louise E. Bird, Luigi De Colibus, Raymond J. Owens, David A. Calderwood, Mark S. P. Sansom, Robert J. C. Gilbert
J Biol Chem. 2012 Dec 21; 287(52): 43246–43261. Published online 2012 Nov 6. doi: 10.1074/jbc.M112.422089
PMCID:
PMC3527912
Abstract Article PDF–3.6M
The Mammalian Proteins MMS19, MIP18, and ANT2 Are Involved in Cytoplasmic Iron-Sulfur Cluster Protein Assembly
Niek van Wietmarschen, Annie Moradian, Gregg B. Morin, Peter M. Lansdorp, Evert-Jan Uringa
J Biol Chem. 2012 Dec 21; 287(52): 43351–43358. Published online 2012 Nov 13. doi: 10.1074/jbc.M112.431270
PMCID:
PMC3527922
Abstract Article PDF–1.0M
The Role of Microtubules and Their Dynamics in Cell Migration
Anutosh Ganguly, Hailing Yang, Ritu Sharma, Kamala D. Patel, Fernando Cabral
J Biol Chem. 2012 Dec 21; 287(52): 43359–43369. Published online 2012 Nov 7. doi: 10.1074/jbc.M112.423905
PMCID:
PMC3527923
Abstract Article PDF–1.7M
RSK2 Protein Suppresses Integrin Activation and Fibronectin Matrix Assembly and Promotes Cell Migration
Joanna E. Gawecka, Shirley S. Young-Robbins, Florian J. Sulzmaier, Maisel J. Caliva, Minna M. Heikkilä, Michelle L. Matter, Joe W. Ramos
J Biol Chem. 2012 Dec 21; 287(52): 43424–43437. Published online 2012 Nov 1. doi: 10.1074/jbc.M112.423046
PMCID:
PMC3527930
Abstract Article PDF–4.2M
The M2 Module of the Cys-His-rich Domain (CHRD) of PCSK9 Protein Is Needed for the Extracellular Low-density Lipoprotein Receptor (LDLR) Degradation Pathway
Yascara Grisel Luna Saavedra, Robert Day, Nabil G. Seidah
J Biol Chem. 2012 Dec 21; 287(52): 43492–43501. Published online 2012 Oct 26. doi: 10.1074/jbc.M112.394023
PMCID:
PMC3527936
Abstract Article PDF–2.0M
Staurosporines Disrupt Phosphatidylserine Trafficking and Mislocalize Ras Proteins
Kwang-jin Cho, Jin-Hee Park, Andrew M. Piggott, Angela A. Salim, Alemaheyu A. Gorfe, Robert G. Parton, Robert J. Capon, Ernest Lacey, John F. Hancock
J Biol Chem. 2012 Dec 21; 287(52): 43573–43584. Published online 2012 Nov 2. doi: 10.1074/jbc.M112.424457
PMCID:
PMC3527944
Abstract Article PDF–3.6M
The Structure of Sec12 Implicates Potassium Ion Coordination in Sar1 Activation
Conor McMahon, Sean M. Studer, Chaevia Clendinen, Geoffrey P. Dann, Philip D. Jeffrey, Frederick M. Hughson
J Biol Chem. 2012 Dec 21; 287(52): 43599–43606. Published online 2012 Oct 29. doi: 10.1074/jbc.M112.420141
PMCID:
PMC3527946
Abstract Article PDF–2.0M
Reduced PDZ Interactions of Rescued ΔF508CFTR Increases Its Cell Surface Mobility
Cathleen D. Valentine, Gergely L. Lukacs, Alan S. Verkman, Peter M. Haggie
J Biol Chem. 2012 Dec 21; 287(52): 43630–43638. Published online 2012 Oct 31. doi: 10.1074/jbc.M112.421172
PMCID:
PMC3527949
Abstract Article PDF–1.4M
Multivalent Pseudopeptides Targeting Cell Surface Nucleoproteins Inhibit Cancer Cell Invasion through Tissue Inhibitor of Metalloproteinases 3 (TIMP-3) Release
Damien Destouches, Eric Huet, Maha Sader, Sophie Frechault, Gilles Carpentier, Florie Ayoul, Jean-Paul Briand, Suzanne Menashi, José Courty
J Biol Chem. 2012 Dec 21; 287(52): 43685–43693. Published online 2012 Oct 29. doi: 10.1074/jbc.M112.380402
PMCID:
PMC3527954
Abstract Article PDF–2.5M
An Emerging Role of Sonic Hedgehog Shedding as a Modulator of Heparan Sulfate Interactions
Stefanie Ohlig, Ute Pickhinke, Svetlana Sirko, Shyam Bandari, Daniel Hoffmann, Rita Dreier, Pershang Farshi, Magdalena Götz, Kay Grobe
J Biol Chem. 2012 Dec 21; 287(52): 43708–43719. Published online 2012 Nov 1. doi: 10.1074/jbc.M112.356667
Correction in:
J Biol Chem. 2013 Feb 15; 288(7): 5049.
PMCID:
PMC3527956
Abstract Article PDF–2.0M
Munc18-1 Controls SNARE Protein Complex Assembly during Human Sperm Acrosomal Exocytosis
Facundo Rodríguez, M. Natalia Zanetti, Luis S. Mayorga, Claudia N. Tomes
J Biol Chem. 2012 Dec 21; 287(52): 43825–43839. Published online 2012 Oct 22. doi: 10.1074/jbc.M112.409649
PMCID:
PMC3527966
Abstract Article PDF–3.8M
The Enzymatic Activity of Apoptosis-inducing Factor Supports Energy Metabolism Benefiting the Growth and Invasiveness of Advanced Prostate Cancer Cells
Eric M. Lewis, Amanda S. Wilkinson, Jacqueline S. Jackson, Rohit Mehra, Sooryanarayana Varambally, Arul M. Chinnaiyan, John C. Wilkinson
J Biol Chem. 2012 Dec 21; 287(52): 43862–43875. Published online 2012 Nov 1. doi: 10.1074/jbc.M112.407650
PMCID:
PMC3527969
Abstract Article PDF–2.2M
The RING Finger Protein RNF8 Ubiquitinates Nbs1 to Promote DNA Double-strand Break Repair by Homologous Recombination
Chi-Sheng Lu, Lan N. Truong, Aaron Aslanian, Linda Z. Shi, Yongjiang Li, Patty Yi-Hwa Hwang, Kwi Hye Koh, Tony Hunter, John R. Yates, III, Michael W. Berns, Xiaohua Wu
J Biol Chem. 2012 Dec 21; 287(52): 43984–43994. Published online 2012 Oct 31. doi: 10.1074/jbc.M112.421545
PMCID:
PMC3527981
Abstract Article PDF–1.8M

DNA and Chromosomes

Activation of the SNF2 Family ATPase ALC1 by Poly(ADP-ribose) in a Stable ALC1·PARP1·Nucleosome Intermediate
Aaron J. Gottschalk, Rushi D. Trivedi, Joan W. Conaway, Ronald C. Conaway
J Biol Chem. 2012 Dec 21; 287(52): 43527–43532. Published online 2012 Nov 6. doi: 10.1074/jbc.M112.401141
PMCID:
PMC3527939
Abstract Article PDF–1.1M
Alcohol-induced One-carbon Metabolism Impairment Promotes Dysfunction of DNA Base Excision Repair in Adult Brain
Anna-Kate Fowler, Aveline Hewetson, Rajiv G. Agrawal, Marisela Dagda, Raul Dagda, Ruin Moaddel, Silvia Balbo, Mitesh Sanghvi, Yukun Chen, Ryan J. Hogue, Susan E. Bergeson, George I. Henderson, Inna I. Kruman
J Biol Chem. 2012 Dec 21; 287(52): 43533–43542. Published online 2012 Nov 1. doi: 10.1074/jbc.M112.401497
PMCID:
PMC3527940
Abstract Article PDF–1.6M

Developmental Biology

Stac3 Is Required for Myotube Formation and Myogenic Differentiation in Vertebrate Skeletal Muscle
Neil I. Bower, Daniel Garcia de la serrana, Nicholas J. Cole, Georgina E. Hollway, Hung-Tai Lee, Stephen Assinder, Ian A. Johnston
J Biol Chem. 2012 Dec 21; 287(52): 43936–43949. Published online 2012 Oct 17. doi: 10.1074/jbc.M112.361311
PMCID:
PMC3527977
Abstract Article PDF–6.1M

Enzymology

Dissecting and Reconstructing Synergism: IN SITU VISUALIZATION OF COOPERATIVITY AMONG CELLULASES
Thomas Ganner, Patricia Bubner, Manuel Eibinger, Claudia Mayrhofer, Harald Plank, Bernd Nidetzky
J Biol Chem. 2012 Dec 21; 287(52): 43215–43222. Published online 2012 Nov 1. doi: 10.1074/jbc.M112.419952
PMCID:
PMC3527909
Abstract Article PDF–1.5M
Revisiting the Nucleotide and Aminoglycoside Substrate Specificity of the Bifunctional Aminoglycoside Acetyltransferase(6′)-Ie/Aminoglycoside Phosphotransferase(2″)-Ia Enzyme
Hilary Frase, Marta Toth, Sergei B. Vakulenko
J Biol Chem. 2012 Dec 21; 287(52): 43262–43269. Published online 2012 Oct 31. doi: 10.1074/jbc.M112.416453
PMCID:
PMC3527913
Abstract Article PDF–806K
Structural Enzymology of Cellvibrio japonicus Agd31B Protein Reveals α-Transglucosylase Activity in Glycoside Hydrolase Family 31
Johan Larsbrink, Atsushi Izumi, Glyn R. Hemsworth, Gideon J. Davies, Harry Brumer
J Biol Chem. 2012 Dec 21; 287(52): 43288–43299. Published online 2012 Nov 6. doi: 10.1074/jbc.M112.416511
PMCID:
PMC3527916
Abstract Article PDF–1.6M
Foamy Virus Envelope Protein Is a Substrate for Signal Peptide Peptidase-like 3 (SPPL3)
Matthias Voss, Akio Fukumori, Peer-Hendrik Kuhn, Ulrike Künzel, Bärbel Klier, Gudula Grammer, Martina Haug-Kröper, Elisabeth Kremmer, Stefan F. Lichtenthaler, Harald Steiner, Bernd Schröder, Christian Haass, Regina Fluhrer
J Biol Chem. 2012 Dec 21; 287(52): 43401–43409. Published online 2012 Nov 6. doi: 10.1074/jbc.M112.371369
PMCID:
PMC3527927
Abstract Article PDF–2.6M
Detection of Reaction Intermediates during Human Cystathionine β-Synthase-monitored Turnover and H2S Production
Pramod Kumar Yadav, Ruma Banerjee
J Biol Chem. 2012 Dec 21; 287(52): 43464–43471. Published online 2012 Nov 2. doi: 10.1074/jbc.M112.414722
PMCID:
PMC3527933
Abstract Article PDF–1.3M

Gene Regulation

A Subset of Mixed Lineage Leukemia Proteins Has Plant Homeodomain (PHD)-mediated E3 Ligase Activity
Jingya Wang, Andrew G. Muntean, Laura Wu, Jay L. Hess
J Biol Chem. 2012 Dec 21; 287(52): 43410–43416. Published online 2012 Nov 5. doi: 10.1074/jbc.M112.423855
PMCID:
PMC3527928
Abstract Article PDF–2.2M
Human SMC2 Protein, a Core Subunit of Human Condensin Complex, Is a Novel Transcriptional Target of the WNT Signaling Pathway and a New Therapeutic Target
Verónica Dávalos, Lucía Súarez-López, Julio Castaño, Anthea Messent, Ibane Abasolo, Yolanda Fernandez, Angel Guerra-Moreno, Eloy Espín, Manel Armengol, Eva Musulen, Aurelio Ariza, Joan Sayós, Diego Arango, Simó Schwartz, Jr.
J Biol Chem. 2012 Dec 21; 287(52): 43472–43481. Published online 2012 Oct 24. doi: 10.1074/jbc.M112.428466
PMCID:
PMC3527934
Abstract Article PDF–2.0M
Induction of DNA Demethylation Depending on Two Sets of Sox2 and Adjacent Oct3/4 Binding Sites (Sox-Oct Motifs) within the Mouse H19/Insulin-like Growth Factor 2 (Igf2) Imprinted Control Region
Naohiro Hori, Mariko Yamane, Kaori Kouno, Kenzo Sato
J Biol Chem. 2012 Dec 21; 287(52): 44006–44016. Published online 2012 Oct 31. doi: 10.1074/jbc.M112.424580
PMCID:
PMC3527983
Abstract Article PDF–1.7M

Glycobiology and Extracellular Matrices

Exploring the Unique N-Glycome of the Opportunistic Human Pathogen Acanthamoeba
Birgit Schiller, Georgia Makrypidi, Ebrahim Razzazi-Fazeli, Katharina Paschinger, Julia Walochnik, Iain B. H. Wilson
J Biol Chem. 2012 Dec 21; 287(52): 43191–43204. Published online 2012 Nov 8. doi: 10.1074/jbc.M112.418095
PMCID:
PMC3527907
Abstract Article PDF–3.8M
Construction of a Chondroitin Sulfate Library with Defined Structures and Analysis of Molecular Interactions
Nobuo Sugiura, Tatsumasa Shioiri, Mie Chiba, Takashi Sato, Hisashi Narimatsu, Koji Kimata, Hideto Watanabe
J Biol Chem. 2012 Dec 21; 287(52): 43390–43400. Published online 2012 Nov 5. doi: 10.1074/jbc.M112.412676
PMCID:
PMC3527926
Abstract Article PDF–2.4M
Endorepellin Affects Angiogenesis by Antagonizing Diverse Vascular Endothelial Growth Factor Receptor 2 (VEGFR2)-evoked Signaling Pathways: TRANSCRIPTIONAL REPRESSION OF HYPOXIA-INDUCIBLE FACTOR 1α AND VEGFA AND CONCURRENT INHIBITION OF NUCLEAR FACTOR OF ACTIVATED T CELL 1 (NFAT1) ACTIVATION
Atul Goyal, Chiara Poluzzi, Chris D. Willis, James Smythies, Adam Shellard, Thomas Neill, Renato V. Iozzo
J Biol Chem. 2012 Dec 21; 287(52): 43543–43556. Published online 2012 Oct 11. doi: 10.1074/jbc.M112.401786
PMCID:
PMC3527941
Abstract Article PDF–2.7M

Immunology

LUZ-Y, a Novel Platform for the Mammalian Cell Production of Full-length IgG-bispecific Antibodies
Bernd J. Wranik, Erin L. Christensen, Gabriele Schaefer, Janet K. Jackman, Andrew C. Vendel, Dan Eaton
J Biol Chem. 2012 Dec 21; 287(52): 43331–43339. Published online 2012 Nov 1. doi: 10.1074/jbc.M112.397869
PMCID:
PMC3527920
Abstract Article PDF–1.6M
Toll-like Receptor 11 (TLR11) Prevents Salmonella Penetration into the Murine Peyer Patches
Zhongcheng Shi, Zhenyu Cai, Jingcui Yu, Tingting Zhang, Shu Zhao, Emanuel Smeds, Qingyuan Zhang, Fen Wang, Changhong Zhao, Songbin Fu, Sankar Ghosh, Dekai Zhang
J Biol Chem. 2012 Dec 21; 287(52): 43417–43423. Published online 2012 Nov 7. doi: 10.1074/jbc.M112.411009
PMCID:
PMC3527929
Abstract Article PDF–1.8M
Apolipoproteins and Apolipoprotein Mimetic Peptides Modulate Phagocyte Trafficking through Chemotactic Activity
Jennifer H. Madenspacher, Kathleen M. Azzam, Wanghua Gong, Kymberly M. Gowdy, Michael P. Vitek, Daniel T. Laskowitz, Alan T. Remaley, Ji Ming Wang, Michael B. Fessler
J Biol Chem. 2012 Dec 21; 287(52): 43730–43740. Published online 2012 Nov 1. doi: 10.1074/jbc.M112.377192
PMCID:
PMC3527958
Abstract Article PDF–2.1M

Lipids

Activation of Liver X Receptor Induces Macrophage Interleukin-5 Expression
Yuanli Chen, Yajun Duan, Yanhua Kang, Xiaoxiao Yang, Meixiu Jiang, Ling Zhang, Guangliang Li, Zhinan Yin, Wenquan Hu, Pengzhi Dong, Xiaoju Li, David P. Hajjar, Jihong Han
J Biol Chem. 2012 Dec 21; 287(52): 43340–43350. Published online 2012 Nov 13. doi: 10.1074/jbc.M112.403394
PMCID:
PMC3527921
Abstract Article PDF–3.0M

Membrane Biology

Role of Conformational Dynamics in α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid (AMPA) Receptor Partial Agonism
Swarna Ramaswamy, David Cooper, Nitesh Poddar, David M. MacLean, Anu Rambhadran, J. Nick Taylor, Heui Uhm, Christy F. Landes, Vasanthi Jayaraman
J Biol Chem. 2012 Dec 21; 287(52): 43557–43564. Published online 2012 Oct 31. doi: 10.1074/jbc.M112.371815
PMCID:
PMC3527942
Abstract Article PDF–1.3M
Localization and Substrate Selectivity of Sea Urchin Multidrug (MDR) Efflux Transporters
Tufan Gökirmak, Joseph P. Campanale, Lauren E. Shipp, Gary W. Moy, Houchao Tao, Amro Hamdoun
J Biol Chem. 2012 Dec 21; 287(52): 43876–43883. Published online 2012 Nov 2. doi: 10.1074/jbc.M112.424879
PMCID:
PMC3527970
Abstract Article PDF–1.2M
Phosphatidylethanolamine Biosynthesis in Mitochondria: PHOSPHATIDYLSERINE (PS) TRAFFICKING IS INDEPENDENT OF A PS DECARBOXYLASE AND INTERMEMBRANE SPACE PROTEINS UPS1P AND UPS2P
Yasushi Tamura, Ouma Onguka, Kie Itoh, Toshiya Endo, Miho Iijima, Steven M. Claypool, Hiromi Sesaki
J Biol Chem. 2012 Dec 21; 287(52): 43961–43971. Published online 2012 Nov 2. doi: 10.1074/jbc.M112.390997
PMCID:
PMC3527979
Abstract Article PDF–2.1M
Cysteine 70 of Ankyrin-G Is S-Palmitoylated and Is Required for Function of Ankyrin-G in Membrane Domain Assembly
Meng He, Paul Jenkins, Vann Bennett
J Biol Chem. 2012 Dec 21; 287(52): 43995–44005. Published online 2012 Nov 5. doi: 10.1074/jbc.M112.417501
PMCID:
PMC3527982
Abstract Article PDF–3.2M

Metabolism

Furin-cleaved Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Is Active and Modulates Low Density Lipoprotein Receptor and Serum Cholesterol Levels
Michael T. Lipari, Wei Li, Paul Moran, Monica Kong-Beltran, Tao Sai, Joyce Lai, S. Jack Lin, Ganesh Kolumam, Jose Zavala-Solorio, Anita Izrael-Tomasevic, David Arnott, Jianyong Wang, Andrew S. Peterson, Daniel Kirchhofer
J Biol Chem. 2012 Dec 21; 287(52): 43482–43491. Published online 2012 Nov 7. doi: 10.1074/jbc.M112.380618
PMCID:
PMC3527935
Abstract Article PDF–1.5M
The mRNA-stabilizing Factor HuR Protein Is Targeted by β-TrCP Protein for Degradation in Response to Glycolysis Inhibition
Po-Chen Chu, Hsiao-Ching Chuang, Samuel K. Kulp, Ching-Shih Chen
J Biol Chem. 2012 Dec 21; 287(52): 43639–43650. Published online 2012 Oct 31. doi: 10.1074/jbc.M112.393678
PMCID:
PMC3527950
Abstract Article PDF–2.9M

Microbiology

FlaX, A Unique Component of the Crenarchaeal Archaellum, Forms Oligomeric Ring-shaped Structures and Interacts with the Motor ATPase FlaI
Ankan Banerjee, Abhrajyoti Ghosh, Deryck J. Mills, Jörg Kahnt, Janet Vonck, Sonja-Verena Albers
J Biol Chem. 2012 Dec 21; 287(52): 43322–43330. Published online 2012 Nov 5. doi: 10.1074/jbc.M112.414383
PMCID:
PMC3527919
Abstract Article PDF–2.0M
Functional and Structural Insights of a Staphylococcus aureus Apoptotic-like Membrane Peptide from a Toxin-Antitoxin Module
Nour Sayed, Sylvie Nonin-Lecomte, Stéphane Réty, Brice Felden
J Biol Chem. 2012 Dec 21; 287(52): 43454–43463. Published online 2012 Nov 5. doi: 10.1074/jbc.M112.402693
PMCID:
PMC3527932
Abstract Article PDF–1.9M
Genetic Analysis of the Hox Hydrogenase in the Cyanobacterium Synechocystis sp. PCC 6803 Reveals Subunit Roles in Association, Assembly, Maturation, and Function
Carrie Eckert, Marko Boehm, Damian Carrieri, Jianping Yu, Alexandra Dubini, Peter J. Nixon, Pin-Ching Maness
J Biol Chem. 2012 Dec 21; 287(52): 43502–43515. Published online 2012 Nov 8. doi: 10.1074/jbc.M112.392407
PMCID:
PMC3527937
Abstract Article PDF–2.0M
A Universally Conserved ATPase Regulates the Oxidative Stress Response in Escherichia coli
Meike Wenk, Qiaorui Ba, Veronika Erichsen, Katherine MacInnes, Heike Wiese, Bettina Warscheid, Hans-Georg Koch
J Biol Chem. 2012 Dec 21; 287(52): 43585–43598. Published online 2012 Nov 8. doi: 10.1074/jbc.M112.413070
PMCID:
PMC3527945
Abstract Article PDF–2.3M
A Novel Mode of Regulation of the Staphylococcus aureus Catabolite Control Protein A (CcpA) Mediated by Stk1 Protein Phosphorylation
Jade Leiba, Torsten Hartmann, Marie-Eve Cluzel, Martin Cohen-Gonsaud, Frédéric Delolme, Markus Bischoff, Virginie Molle
J Biol Chem. 2012 Dec 21; 287(52): 43607–43619. Published online 2012 Nov 6. doi: 10.1074/jbc.M112.418913
PMCID:
PMC3527947
Abstract Article PDF–2.7M
Characterization and Structure of the Aquifex aeolicus Protein DUF752: A BACTERIAL tRNA-METHYLTRANSFERASE (MnmC2) FUNCTIONING WITHOUT THE USUALLY FUSED OXIDASE DOMAIN (MnmC1)
Aya Kitamura, Madoka Nishimoto, Toru Sengoku, Rie Shibata, Gunilla Jäger, Glenn R. Björk, Henri Grosjean, Shigeyuki Yokoyama, Yoshitaka Bessho
J Biol Chem. 2012 Dec 21; 287(52): 43950–43960. Published online 2012 Oct 22. doi: 10.1074/jbc.M112.409300
PMCID:
PMC3527978
Abstract Article PDF–2.5M

Molecular Bases of Disease

Activation of Phosphatidylinositol 3-Kinase (PI3K) and Mitogen-activated Protein Kinase (MAPK) Signaling and the Consequent Induction of Transformation by Overexpressed 14-3-3γ Protein Require Specific Amino Acids within 14-3-3γ N-terminal Variable Region II
Vijayababu M. Radhakrishnan, Charles W. Putnam, Jesse D. Martinez
J Biol Chem. 2012 Dec 21; 287(52): 43300–43311. Published online 2012 Oct 31. doi: 10.1074/jbc.M112.397877
PMCID:
PMC3527917
Abstract Article PDF–2.2M
Na+/H+ Exchanger Regulatory Factor 1 (NHERF1) Directly Regulates Osteogenesis
Li Liu, Veronica Alonso, Lida Guo, Irina Tourkova, Sarah E. Henderson, Alejandro J. Almarza, Peter A. Friedman, Harry C. Blair
J Biol Chem. 2012 Dec 21; 287(52): 43312–43321. Published online 2012 Oct 29. doi: 10.1074/jbc.M112.422766
PMCID:
PMC3527918
Abstract Article PDF–2.6M
Cancer Cells Induced to Express Mesenchymal Phenotype Release Exosome-like Extracellular Vesicles Carrying Tissue Factor
Delphine Garnier, Nathalie Magnus, Tae Hoon Lee, Victoria Bentley, Brian Meehan, Chloe Milsom, Laura Montermini, Thomas Kislinger, Janusz Rak
J Biol Chem. 2012 Dec 21; 287(52): 43565–43572. Published online 2012 Nov 1. doi: 10.1074/jbc.M112.401760
PMCID:
PMC3527943
Abstract Article PDF–2.3M
The Heat Shock Response Is Modulated by and Interferes with Toxic Effects of Scrapie Prion Protein and Amyloid β
Ulrike K. Resenberger, Veronika Müller, Lisa M. Munter, Michael Baier, Gerd Multhaup, Mark R. Wilson, Konstanze F. Winklhofer, Jörg Tatzelt
J Biol Chem. 2012 Dec 21; 287(52): 43765–43776. Published online 2012 Oct 31. doi: 10.1074/jbc.M112.389007
PMCID:
PMC3527961
Abstract Article PDF–1.5M
Functional Genetic Variants of the Catecholamine-Release-Inhibitory Peptide Catestatin in an Indian Population: ALLELE-SPECIFIC EFFECTS ON METABOLIC TRAITS
Bhavani S. Sahu, Jagan M. Obbineni, Giriraj Sahu, Prasanna K. R. Allu, Lakshmi Subramanian, Parshuram J. Sonawane, Pradeep K. Singh, Binu K. Sasi, Sanjib Senapati, Samir K. Maji, Amal K. Bera, Balashankar S. Gomathi, Ajit S. Mullasari, Nitish R. Mahapatra
J Biol Chem. 2012 Dec 21; 287(52): 43840–43852. Published online 2012 Oct 26. doi: 10.1074/jbc.M112.407916
PMCID:
PMC3527967
Abstract Article PDF–3.0M
Functional Analysis of Missense Mutations in Kv8.2 Causing Cone Dystrophy with Supernormal Rod Electroretinogram
Katie E. Smith, Susan E. Wilkie, Joseph T. Tebbs-Warner, Bradley J. Jarvis, Linn Gallasch, Martin Stocker, David M. Hunt
J Biol Chem. 2012 Dec 21; 287(52): 43972–43983. Published online 2012 Oct 31. doi: 10.1074/jbc.M112.388033
PMCID:
PMC3527980
Abstract Article PDF–2.7M

Molecular Biophysics

Role of the Actin Ala-108–Pro-112 Loop in Actin Polymerization and ATPase Activities
Mitsusada Iwasa, Tomoki Aihara, Kayo Maeda, Akihiro Narita, Yuichiro Maéda, Toshiro Oda
J Biol Chem. 2012 Dec 21; 287(52): 43270–43276. Published online 2012 Nov 7. doi: 10.1074/jbc.M112.392019
PMCID:
PMC3527914
Abstract Article PDF–1.5M
Three-Dimensional Localization of the α and β Subunits and of the II-III Loop in the Skeletal Muscle L-type Ca2+ Channel
John Szpyt, Nancy Lorenzon, Claudio F. Perez, Ethan Norris, Paul D. Allen, Kurt G. Beam, Montserrat Samsó
J Biol Chem. 2012 Dec 21; 287(52): 43853–43861. Published online 2012 Nov 1. doi: 10.1074/jbc.M112.419283
PMCID:
PMC3527968
Abstract Article PDF–1.8M

Neurobiology

Interaction of Antidepressants with the Serotonin and Norepinephrine Transporters: MUTATIONAL STUDIES OF THE S1 SUBSTRATE BINDING POCKET
Lena Sørensen, Jacob Andersen, Mette Thomsen, Stinna M. R. Hansen, Xiaobei Zhao, Albin Sandelin, Kristian Strømgaard, Anders S. Kristensen
J Biol Chem. 2012 Dec 21; 287(52): 43694–43707. Published online 2012 Oct 19. doi: 10.1074/jbc.M112.342212
PMCID:
PMC3527955
Abstract Article PDF–2.7M
Disease-associated Mutations in the Prion Protein Impair Laminin-induced Process Outgrowth and Survival
Cleiton F. Machado, Flavio H. Beraldo, Tiago G. Santos, Dominique Bourgeon, Michele C. Landemberger, Martin Roffé, Vilma R. Martins
J Biol Chem. 2012 Dec 21; 287(52): 43777–43788. Published online 2012 Nov 6. doi: 10.1074/jbc.M112.428235
PMCID:
PMC3527962
Abstract Article PDF–2.3M
Mapping of the Interaction Site between Sortilin and the p75 Neurotrophin Receptor Reveals a Regulatory Role for the Sortilin Intracellular Domain in p75 Neurotrophin Receptor Shedding and Apoptosis
Sune Skeldal, Alex M. Sykes, Simon Glerup, Dusan Matusica, Nickless Palstra, Henri Autio, Zoran Boskovic, Peder Madsen, Eero Castrén, Anders Nykjaer, Elizabeth J. Coulson
J Biol Chem. 2012 Dec 21; 287(52): 43798–43809. Published online 2012 Oct 26. doi: 10.1074/jbc.M112.374710
PMCID:
PMC3527964
Abstract Article PDF–4.4M
The Effects of Transmembrane Sequence and Dimerization on Cleavage of the p75 Neurotrophin Receptor by γ-Secretase
Alex M. Sykes, Nickless Palstra, Daniel Abankwa, Justine M. Hill, Sune Skeldal, Dusan Matusica, Prahatha Venkatraman, John F. Hancock, Elizabeth J. Coulson
J Biol Chem. 2012 Dec 21; 287(52): 43810–43824. Published online 2012 Oct 26. doi: 10.1074/jbc.M112.382903
PMCID:
PMC3527965
Abstract Article PDF–2.5M

Plant Biology

The E3 Ubiquitin Ligase HOS1 Regulates Arabidopsis Flowering by Mediating CONSTANS Degradation Under Cold Stress
Jae-Hoon Jung, Pil Joon Seo, Chung-Mo Park
J Biol Chem. 2012 Dec 21; 287(52): 43277–43287. Published online 2012 Nov 7. doi: 10.1074/jbc.M112.394338
PMCID:
PMC3527915
Abstract Article PDF–2.3M

Protein Structure and Folding

Tau Oligomers Impair Artificial Membrane Integrity and Cellular Viability
Katharina Flach, Isabel Hilbrich, Andrea Schiffmann, Ulrich Gärtner, Martin Krüger, Marion Leonhardt, Hanka Waschipky, Lukas Wick, Thomas Arendt, Max Holzer
J Biol Chem. 2012 Dec 21; 287(52): 43223–43233. Published online 2012 Nov 5. doi: 10.1074/jbc.M112.396176
PMCID:
PMC3527910
Abstract Article PDF–2.8M
The Glaucoma-associated Olfactomedin Domain of Myocilin Is a Novel Calcium Binding Protein
Rebecca K. Donegan, Shannon E. Hill, Katherine C. Turnage, Susan D. Orwig, Raquel L. Lieberman
J Biol Chem. 2012 Dec 21; 287(52): 43370–43377. Published online 2012 Nov 5. doi: 10.1074/jbc.M112.408906
PMCID:
PMC3527924
Abstract Article PDF–1.3M
Cyclotides Insert into Lipid Bilayers to Form Membrane Pores and Destabilize the Membrane through Hydrophobic and Phosphoethanolamine-specific Interactions
Conan K. Wang, Hanna P. Wacklin, David J. Craik
J Biol Chem. 2012 Dec 21; 287(52): 43884–43898. Published online 2012 Nov 5. doi: 10.1074/jbc.M112.421198
PMCID:
PMC3527971
Abstract Article PDF–5.8M
Structural Basis of Molecular Recognition between ESCRT-III-like Protein Vps60 and AAA-ATPase Regulator Vta1 in the Multivesicular Body Pathway
Zhongzheng Yang, Cody Vild, Jiaying Ju, Xu Zhang, Jianping Liu, Jie Shen, Bin Zhao, Wenxian Lan, Fuchun Gong, Maili Liu, Chunyang Cao, Zhaohui Xu
J Biol Chem. 2012 Dec 21; 287(52): 43899–43908. Published online 2012 Oct 26. doi: 10.1074/jbc.M112.390724
PMCID:
PMC3527972
Abstract Article PDF–2.9M
Structural Basis for Activation of the Vps4 ATPase♦: Structural Basis of Molecular Recognition between ESCRT-III-like Protein Vps60 and AAA-ATPase Regulator Vta1 in the Multivesicular Body Pathway
J Biol Chem. 2012 Dec 21; 287(52): 43909. doi: 10.1074/jbc.P112.390724
PMCID:
PMC3527973
Article PDF–532K
Interactions of the Human LIP5 Regulatory Protein with Endosomal Sorting Complexes Required for Transport
Jack J. Skalicky, Jun Arii, Dawn M. Wenzel, William-May B. Stubblefield, Angela Katsuyama, Nathan T. Uter, Monika Bajorek, David G. Myszka, Wesley I. Sundquist
J Biol Chem. 2012 Dec 21; 287(52): 43910–43908. Published online 2012 Oct 26. doi: 10.1074/jbc.M112.417899
PMCID:
PMC3527974
Abstract Article PDF–4.3M
The Biochemical and Structural Basis for a Pathway Involved in Membrane Remodeling and Fission♦: Interactions of the Human LIP5 Regulatory Protein with Endosomal Sorting Complexes Required for Transport
J Biol Chem. 2012 Dec 21; 287(52): 43927. doi: 10.1074/jbc.P112.417899
PMCID:
PMC3527975
Article PDF–355K

Protein Synthesis and Degradation

The Stability of the Small Nucleolar Ribonucleoprotein (snoRNP) Assembly Protein Pih1 in Saccharomyces cerevisiae Is Modulated by Its C Terminus
Alexandr Paci, Xiao Hu Liu, Hao Huang, Abelyn Lim, Walid A. Houry, Rongmin Zhao
J Biol Chem. 2012 Dec 21; 287(52): 43205–43214. Published online 2012 Nov 8. doi: 10.1074/jbc.M112.408849
PMCID:
PMC3527908
Abstract Article PDF–1.9M
Ubiquitin-specific Protease 9x Deubiquitinates and Stabilizes the Spinal Muscular Atrophy Protein-Survival Motor Neuron
Ke-Jun Han, Daniel G. Foster, Nan-Yan Zhang, Kavdia Kanisha, Monika Dzieciatkowska, Robert A. Sclafani, Kirk C. Hansen, Junmin Peng, Chang-Wei Liu
J Biol Chem. 2012 Dec 21; 287(52): 43741–43752. Published online 2012 Oct 30. doi: 10.1074/jbc.M112.372318
PMCID:
PMC3527959
Abstract Article PDF–1.9M

Signal Transduction

G Protein-coupled Estrogen Receptor Mediates the Up-regulation of Fatty Acid Synthase Induced by 17β-Estradiol in Cancer Cells and Cancer-associated Fibroblasts
Maria Francesca Santolla, Rosamaria Lappano, Paola De Marco, Marco Pupo, Adele Vivacqua, Diego Sisci, Sergio Abonante, Domenico Iacopetta, Anna Rita Cappello, Vincenza Dolce, Marcello Maggiolini
J Biol Chem. 2012 Dec 21; 287(52): 43234–43245. Published online 2012 Nov 7. doi: 10.1074/jbc.M112.417303
PMCID:
PMC3527911
Abstract Article PDF–4.5M
Selective Proteasomal Degradation of the B′β Subunit of Protein Phosphatase 2A by the E3 Ubiquitin Ligase Adaptor Kelch-like 15
Elizabeth A. Oberg, Shanna K. Nifoussi, Anne-Claude Gingras, Stefan Strack
J Biol Chem. 2012 Dec 21; 287(52): 43378–43389. Published online 2012 Nov 7. doi: 10.1074/jbc.M112.420281
PMCID:
PMC3527925
Abstract Article PDF–2.5M
The F-BAR Protein PACSIN2 Regulates Epidermal Growth Factor Receptor Internalization
Bart-Jan de Kreuk, Eloise C. Anthony, Dirk Geerts, Peter L. Hordijk
J Biol Chem. 2012 Dec 21; 287(52): 43438–43453. Published online 2012 Nov 5. doi: 10.1074/jbc.M112.391078
PMCID:
PMC3527931
Abstract Article PDF–5.0M
PheVI:09 (Phe6.44) as a Sliding Microswitch in Seven-transmembrane (7TM) G Protein-coupled Receptor Activation
Louise Valentin-Hansen, Birgitte Holst, Thomas M. Frimurer, Thue W. Schwartz
J Biol Chem. 2012 Dec 21; 287(52): 43516–43526. Published online 2012 Nov 7. doi: 10.1074/jbc.M112.395137
PMCID:
PMC3527938
Abstract Article PDF–2.9M
Rho-associated Coiled-coil Kinase (ROCK) Protein Controls Microtubule Dynamics in a Novel Signaling Pathway That Regulates Cell Migration
Alice V. Schofield, Rohan Steel, Ora Bernard
J Biol Chem. 2012 Dec 21; 287(52): 43620–43629. Published online 2012 Oct 23. doi: 10.1074/jbc.M112.394965
PMCID:
PMC3527948
Abstract Article PDF–2.6M
RNase L Induces Autophagy via c-Jun N-terminal Kinase and Double-stranded RNA-dependent Protein Kinase Signaling Pathways
Mohammad Adnan Siddiqui, Krishnamurthy Malathi
J Biol Chem. 2012 Dec 21; 287(52): 43651–43664. Published online 2012 Oct 29. doi: 10.1074/jbc.M112.399964
PMCID:
PMC3527951
Abstract Article PDF–4.2M
Regulation of Endothelial Nitric-oxide Synthase (NOS) S-Glutathionylation by Neuronal NOS: EVIDENCE OF A FUNCTIONAL INTERACTION BETWEEN MYOCARDIAL CONSTITUTIVE NOS ISOFORMS
Winifred O. Idigo, Svetlana Reilly, Mei Hua Zhang, Yin Hua Zhang, Raja Jayaram, Ricardo Carnicer, Mark J. Crabtree, Jean-Luc Balligand, Barbara Casadei
J Biol Chem. 2012 Dec 21; 287(52): 43665–43673. Published online 2012 Oct 22. doi: 10.1074/jbc.M112.412031
PMCID:
PMC3527952
Abstract Article PDF–2.3M
Identification of Functionally Critical Residues in the Channel Domain of Inositol Trisphosphate Receptors
Cunnigaiper Bhanumathy, Paula C. A. da Fonseca, Edward P. Morris, Suresh K. Joseph
J Biol Chem. 2012 Dec 21; 287(52): 43674–43684. Published online 2012 Oct 18. doi: 10.1074/jbc.M112.415786
PMCID:
PMC3527953
Abstract Article PDF–1.8M
A Novel Role of Krüppel-like Factor 8 in DNA Repair in Breast Cancer Cells
Heng Lu, Liu Hu, Tianshu Li, Satadru Lahiri, Chao Shen, Melissa S. Wason, Debarati Mukherjee, Hui Xie, Lin Yu, Jihe Zhao
J Biol Chem. 2012 Dec 21; 287(52): 43720–43729. Published online 2012 Oct 26. doi: 10.1074/jbc.M112.418053
PMCID:
PMC3527957
Abstract Article PDF–2.0M
A Small Novel A-Kinase Anchoring Protein (AKAP) That Localizes Specifically Protein Kinase A-Regulatory Subunit I (PKA-RI) to the Plasma Membrane
Pepijn P. Burgers, Yuliang Ma, Luigi Margarucci, Mason Mackey, Marcel A. G. van der Heyden, Mark Ellisman, Arjen Scholten, Susan S. Taylor, Albert J. R. Heck
J Biol Chem. 2012 Dec 21; 287(52): 43789–43797. Published online 2012 Oct 31. doi: 10.1074/jbc.M112.395970
PMCID:
PMC3527963
Abstract Article PDF–1.5M
Articles from The Journal of Biological Chemistry are provided here courtesy of American Society for Biochemistry and Molecular Biology
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