Volume 287(53); 2012 Dec 28

Reflections

My Life with Bacteriophage φ29

Margarita Salas

J Biol Chem. 2012 Dec 28; 287(53): 44568–44579. Published online 2012 Nov 2. doi: 10.1074/jbc.X112.433458

PMCID:: PMC3531770

Abstract Article PDF–1.3M

Cell Biology

The Hect Domain E3 Ligase Tom1 and the F-box Protein Dia2 Control Cdc6 Degradation in G₁ Phase

Dong-Hwan Kim, Wei Zhang, Deanna M. Koepp

J Biol Chem. 2012 Dec 28; 287(53): 44212–44220. Published online 2012 Nov 5. doi: 10.1074/jbc.M112.401778

PMCID:: PMC3531737

Abstract Article PDF–1.6M

The Cannabinoid Receptor CB1 Modulates the Signaling Properties of the Lysophosphatidylinositol Receptor GPR55

Julia Kargl, Nariman Balenga, Gerald P. Parzmair, Andrew J. Brown, Akos Heinemann, Maria Waldhoer

J Biol Chem. 2012 Dec 28; 287(53): 44234–44248. Published online 2012 Nov 16. doi: 10.1074/jbc.M112.364109

PMCID:: PMC3531739

Abstract Article PDF–2.9M

Atg9 Vesicles Recruit Vesicle-tethering Proteins Trs85 and Ypt1 to the Autophagosome Formation Site

Soichiro Kakuta, Hayashi Yamamoto, Lumi Negishi, Chika Kondo-Kakuta, Nobuhiro Hayashi, Yoshinori Ohsumi

J Biol Chem. 2012 Dec 28; 287(53): 44261–44269. Published online 2012 Nov 5. doi: 10.1074/jbc.M112.411454

PMCID:: PMC3531741

Abstract Article PDF–1.8M

Uncoupling Proteostasis and Development in Vitro with a Small Molecule Inhibitor of the Pancreatic Endoplasmic Reticulum Kinase, PERK

Heather P. Harding, Alisa F. Zyryanova, David Ron

J Biol Chem. 2012 Dec 28; 287(53): 44338–44344. Published online 2012 Nov 12. doi: 10.1074/jbc.M112.428987

PMCID:: PMC3531748

Abstract Article PDF–1.3M

Mouse Sperm Membrane Potential Hyperpolarization Is Necessary and Sufficient to Prepare Sperm for the Acrosome Reaction

Jose Luis De La Vega-Beltran, Claudia Sánchez-Cárdenas, Darío Krapf, Enrique O. Hernandez-González, Eva Wertheimer, Claudia L. Treviño, Pablo E. Visconti, Alberto Darszon

J Biol Chem. 2012 Dec 28; 287(53): 44384–44393. Published online 2012 Oct 24. doi: 10.1074/jbc.M112.393488

PMCID:: PMC3531752

Abstract Article PDF–1.5M

SUMO-specific Protease 1 Regulates Mitochondrial Biogenesis through PGC-1α

Rong Cai, Tingting Yu, Chao Huang, Xuefeng Xia, Xiaobing Liu, Jianmin Gu, Song Xue, Edward T.H. Yeh, Jinke Cheng

J Biol Chem. 2012 Dec 28; 287(53): 44464–44470. Published online 2012 Nov 14. doi: 10.1074/jbc.M112.422626

PMCID:: PMC3531759

Abstract Article PDF–1.5M

Tropomyosin Dephosphorylation Results in Compensated Cardiac Hypertrophy

Emily M. Schulz, Richard N. Correll, Hajer N. Sheikh, Marco S. Lofrano-Alves, Patti L. Engel, Gilbert Newman, Jo El J. Schultz, Jeffery D. Molkentin, Beata M. Wolska, R. John Solaro, David F. Wieczorek

J Biol Chem. 2012 Dec 28; 287(53): 44478–44489. Published online 2012 Nov 12. doi: 10.1074/jbc.M112.402040

PMCID:: PMC3531761

Abstract Article PDF–2.9M

Histone Demethylase KDM6B Promotes Epithelial-Mesenchymal Transition

Sivakumar Ramadoss, Xiaohong Chen, Cun-Yu Wang

J Biol Chem. 2012 Dec 28; 287(53): 44508–44517. Published online 2012 Nov 14. doi: 10.1074/jbc.M112.424903

Correction in:: J Biol Chem. 2020 May 8; 295(19): 6781.

PMCID:: PMC3531764

Abstract Article PDF–2.3M

Sphingosine 1-Phosphate (S1P) Carrier-dependent Regulation of Endothelial Barrier: HIGH DENSITY LIPOPROTEIN (HDL)-S1P PROLONGS ENDOTHELIAL BARRIER ENHANCEMENT AS COMPARED WITH ALBUMIN-S1P VIA EFFECTS ON LEVELS, TRAFFICKING, AND SIGNALING OF S1P1

Brent A. Wilkerson, G. Daniel Grass, Shane B. Wing, W. Scott Argraves, Kelley M. Argraves

J Biol Chem. 2012 Dec 28; 287(53): 44645–44653. Published online 2012 Nov 7. doi: 10.1074/jbc.M112.423426

PMCID:: PMC3531779

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Epigenetic Regulation of Galectin-3 Expression by β1 Integrins Promotes Cell Adhesion and Migration

Coert Margadant, Iman van den Bout, Antonius L. van Boxtel, Victor L. Thijssen, Arnoud Sonnenberg

J Biol Chem. 2012 Dec 28; 287(53): 44684–44693. Published online 2012 Nov 1. doi: 10.1074/jbc.M112.426445

PMCID:: PMC3531783

Abstract Article PDF–1.2M

Novel α2β1 Integrin Inhibitors Reveal That Integrin Binding to Collagen under Shear Stress Conditions Does Not Require Receptor Preactivation

Liisa Nissinen, Jarkko Koivunen, Jarmo Käpylä, Maria Salmela, Jonna Nieminen, Johanna Jokinen, Kalle Sipilä, Marjo Pihlavisto, Olli T. Pentikäinen, Anne Marjamäki, Jyrki Heino

J Biol Chem. 2012 Dec 28; 287(53): 44694–44702. Published online 2012 Nov 6. doi: 10.1074/jbc.M111.309450

PMCID:: PMC3531784

Abstract Article PDF–1.6M

Developmental Biology

The Wnt Coreceptor Ryk Regulates Wnt/Planar Cell Polarity by Modulating the Degradation of the Core Planar Cell Polarity Component Vangl2

Philipp Andre, Qianyi Wang, Na Wang, Bo Gao, Arielle Schilit, Michael M. Halford, Steven A. Stacker, Xuemin Zhang, Yingzi Yang

J Biol Chem. 2012 Dec 28; 287(53): 44518–44525. Published online 2012 Nov 9. doi: 10.1074/jbc.M112.414441

PMCID:: PMC3531765

Abstract Article PDF–3.0M

Enzymology

Purification and Characterization of a Novel Galloyltransferase Involved in Catechin Galloylation in the Tea Plant (Camellia sinensis)

Yajun Liu, Liping Gao, Li Liu, Qin Yang, Zhongwei Lu, Zhiyin Nie, Yunsheng Wang, Tao Xia

J Biol Chem. 2012 Dec 28; 287(53): 44406–44417. Published online 2012 Nov 6. doi: 10.1074/jbc.M112.403071

PMCID:: PMC3531754

Abstract Article PDF–2.8M

Characterization of Patient Mutations in Human Persulfide Dioxygenase (ETHE1) Involved in H₂S Catabolism

Omer Kabil, Ruma Banerjee

J Biol Chem. 2012 Dec 28; 287(53): 44561–44567. Published online 2012 Nov 9. doi: 10.1074/jbc.M112.407411

PMCID:: PMC3531769

Abstract Article PDF–1.5M

Structural Characterization of Human Cytochrome P450 2C19: ACTIVE SITE DIFFERENCES BETWEEN P450s 2C8, 2C9, AND 2C19

R. Leila Reynald, Stefaan Sansen, C. David Stout, Eric F. Johnson

J Biol Chem. 2012 Dec 28; 287(53): 44581–44591. Published online 2012 Nov 1. doi: 10.1074/jbc.M112.424895

PMCID:: PMC3531772

Abstract Article PDF–4.2M

Structure of Human Cytochrome P450 2C19, a Critical Enzyme for Drug Metabolism♦: Structural Characterization of Human Cytochrome P450 2C19. Active Site Differences between P450s 2C8, 2C9, and 2C19

J Biol Chem. 2012 Dec 28; 287(53): 44592. doi: 10.1074/jbc.P112.424895

PMCID:: PMC3531773

Article PDF–643K

Transglycosylation by Chitinase D from Serratia proteamaculans Improved through Altered Substrate Interactions

Jogi Madhuprakash, Karunakar Tanneeru, Pallinti Purushotham, Lalitha Guruprasad, Appa Rao Podile

J Biol Chem. 2012 Dec 28; 287(53): 44619–44627. Published online 2012 Oct 31. doi: 10.1074/jbc.M112.400879

PMCID:: PMC3531777

Abstract Article PDF–1.6M

Gene Regulation

Mediator Phosphorylation Prevents Stress Response Transcription During Non-stress Conditions

Christian Miller, Ivan Matic, Kerstin C. Maier, Björn Schwalb, Susanne Roether, Katja Strässer, Achim Tresch, Matthias Mann, Patrick Cramer

J Biol Chem. 2012 Dec 28; 287(53): 44017–44026. Published online 2012 Nov 7. doi: 10.1074/jbc.M112.430140

PMCID:: PMC3531718

Abstract Article PDF–2.1M

Involvement of GDH3-encoded NADP⁺-dependent Glutamate Dehydrogenase in Yeast Cell Resistance to Stress-induced Apoptosis in Stationary Phase Cells

Yong Joo Lee, Kyung Jin Kim, Hong Yong Kang, Hye-Rim Kim, Pil Jae Maeng

J Biol Chem. 2012 Dec 28; 287(53): 44221–44233. Published online 2012 Oct 26. doi: 10.1074/jbc.M112.375360

PMCID:: PMC3531738

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Hypoxia-inducible Factor 1-α Induces miR-210 in Normoxic Differentiating Myoblasts

Lucia Cicchillitti, Valeria Di Stefano, Eleonora Isaia, Luca Crimaldi, Pasquale Fasanaro, Valeria Ambrosino, Annalisa Antonini, Maurizio C. Capogrossi, Carlo Gaetano, Giulia Piaggio, Fabio Martelli

J Biol Chem. 2012 Dec 28; 287(53): 44761–44771. Published online 2012 Nov 12. doi: 10.1074/jbc.M112.421255

PMCID:: PMC3531789

Abstract Article PDF–1.8M

Glycobiology and Extracellular Matrices

Laminin Network Formation Studied by Reconstitution of Ternary Nodes in Solution

Alan Purvis, Erhard Hohenester

J Biol Chem. 2012 Dec 28; 287(53): 44270–44277. Published online 2012 Nov 19. doi: 10.1074/jbc.M112.418426

PMCID:: PMC3531742

Abstract Article PDF–1.7M

Biosynthesis of the Fungal Cell Wall Polysaccharide Galactomannan Requires Intraluminal GDP-mannose

Jakob Engel, Philipp S. Schmalhorst, Françoise H. Routier

J Biol Chem. 2012 Dec 28; 287(53): 44418–44424. Published online 2012 Nov 8. doi: 10.1074/jbc.M112.398321

PMCID:: PMC3531755

Abstract Article PDF–857K

Cyclooxygenase-2 Enzyme Induces the Expression of the α-2,3-Sialyltransferase-3 (ST3Gal-I) in Breast Cancer

Daisy Sproviero, Sylvain Julien, Brian Burford, Joyce Taylor-Papadimitriou, Joy M. Burchell

J Biol Chem. 2012 Dec 28; 287(53): 44490–44497. Published online 2012 Nov 13. doi: 10.1074/jbc.M112.427827

PMCID:: PMC3531762

Abstract Article PDF–1.5M

The NC2 Domain of Type IX Collagen Determines the Chain Register of the Triple Helix

Sergei P. Boudko, Hans Peter Bächinger

J Biol Chem. 2012 Dec 28; 287(53): 44536–44545. Published online 2012 Nov 6. doi: 10.1074/jbc.M112.417543

PMCID:: PMC3531767

Abstract Article PDF–1.4M

A Lectin from the Mussel Mytilus galloprovincialis Has a Highly Novel Primary Structure and Induces Glycan-mediated Cytotoxicity of Globotriaosylceramide-expressing Lymphoma Cells

Yuki Fujii, Naoshi Dohmae, Koji Takio, Sarkar M. A. Kawsar, Ryo Matsumoto, Imtiaj Hasan, Yasuhiro Koide, Robert A. Kanaly, Hidetaro Yasumitsu, Yukiko Ogawa, Shigeki Sugawara, Masahiro Hosono, Kazuo Nitta, Jiharu Hamako, Taei Matsui, Yasuhiro Ozeki

J Biol Chem. 2012 Dec 28; 287(53): 44772–44783. Published online 2012 Oct 23. doi: 10.1074/jbc.M112.418012

Correction in:: J Biol Chem. 2013 Mar 1; 288(9): 6588.

PMCID:: PMC3531790

Abstract Article PDF–3.0M

Functional Glycomic Analysis of Human Milk Glycans Reveals the Presence of Virus Receptors and Embryonic Stem Cell Biomarkers

Ying Yu, Shreya Mishra, Xuezheng Song, Yi Lasanajak, Konrad C. Bradley, Mary M. Tappert, Gillian M. Air, David A. Steinhauer, Sujata Halder, Susan Cotmore, Peter Tattersall, Mavis Agbandje-McKenna, Richard D. Cummings, David F. Smith

J Biol Chem. 2012 Dec 28; 287(53): 44784–44799. Published online 2012 Oct 31. doi: 10.1074/jbc.M112.425819

PMCID:: PMC3531791

Abstract Article PDF–1.2M

Immunology

Differential Arabinan Capping of Lipoarabinomannan Modulates Innate Immune Responses and Impacts T Helper Cell Differentiation

Arun K. Mishra, Joana E. Alves, Karin Krumbach, Jerome Nigou, António G. Castro, Jeroen Geurtsen, Lothar Eggeling, Margarida Saraiva, Gurdyal S. Besra

J Biol Chem. 2012 Dec 28; 287(53): 44173–44183. Published online 2012 Nov 9. doi: 10.1074/jbc.M112.402396

PMCID:: PMC3531733

Abstract Article PDF–1.8M

MUNC13-4 Protein Regulates the Oxidative Response and Is Essential for Phagosomal Maturation and Bacterial Killing in Neutrophils

Jlenia Monfregola, Jennifer Linda Johnson, Michael M. Meijler, Gennaro Napolitano, Sergio Daniel Catz

J Biol Chem. 2012 Dec 28; 287(53): 44603–44618. Published online 2012 Oct 31. doi: 10.1074/jbc.M112.414029

PMCID:: PMC3531776

Abstract Article PDF–3.4M

Structural Basis for Galectin-1-dependent Pre-B Cell Receptor (Pre-BCR) Activation

Latifa Elantak, Marion Espeli, Annie Boned, Olivier Bornet, Jeremy Bonzi, Laurent Gauthier, Mikael Feracci, Philippe Roche, Françoise Guerlesquin, Claudine Schiff

J Biol Chem. 2012 Dec 28; 287(53): 44703–44713. Published online 2012 Nov 2. doi: 10.1074/jbc.M112.395152

PMCID:: PMC3531785

Abstract Article PDF–3.3M

Lipids

Conjugated Linoleic Acid Is a Preferential Substrate for Fatty Acid Nitration

Gustavo Bonacci, Paul R. S. Baker, Sonia R. Salvatore, Darla Shores, Nicholas K. H. Khoo, Jeffrey R. Koenitzer, Dario A. Vitturi, Steven R. Woodcock, Franca Golin-Bisello, Marsha P. Cole, Simon Watkins, Claudette St. Croix, Carlos I. Batthyany, Bruce A. Freeman, Francisco J. Schopfer

J Biol Chem. 2012 Dec 28; 287(53): 44071–44082. Published online 2012 Nov 9. doi: 10.1074/jbc.M112.401356

PMCID:: PMC3531723

Abstract Article PDF–3.0M

Interleukin 1β Regulation of FoxO1 Protein Content and Localization: EVIDENCE FOR A NOVEL CERAMIDE-DEPENDENT MECHANISM

Aneta Dobierzewska, Lihua Shi, Alexander A. Karakashian, Mariana N. Nikolova-Karakashian

J Biol Chem. 2012 Dec 28; 287(53): 44749–44760. Published online 2012 Oct 26. doi: 10.1074/jbc.M112.378836

PMCID:: PMC3531788

Abstract Article PDF–4.1M

Membrane Biology

Role of the Wrist Domain in the Response of the Epithelial Sodium Channel to External Stimuli

Shujie Shi, Marcelo D. Carattino, Thomas R. Kleyman

J Biol Chem. 2012 Dec 28; 287(53): 44027–44035. Published online 2012 Nov 9. doi: 10.1074/jbc.M112.421743

PMCID:: PMC3531719

Abstract Article PDF–2.2M

Cortactin Controls Surface Expression of the Voltage-gated Potassium Channel K_V10.1

Solveig Herrmann, Milena Ninkovic, Tobias Kohl, Éva Lörinczi, Luis A. Pardo

J Biol Chem. 2012 Dec 28; 287(53): 44151–44163. Published online 2012 Nov 9. doi: 10.1074/jbc.M112.372540

PMCID:: PMC3531731

Abstract Article PDF–2.7M

Metabolism

Role of Pin1 Protein in the Pathogenesis of Nonalcoholic Steatohepatitis in a Rodent Model

Yusuke Nakatsu, Yuichiro Otani, Hideyuki Sakoda, Jun Zhang, Ying Guo, Hirofumi Okubo, Akifumi Kushiyama, Midori Fujishiro, Takako Kikuch, Toshiaki Fukushima, Haruya Ohno, Yoshihiro Tsuchiya, Hideaki Kamata, Akiko Nagamachi, Toshiya Inaba, Fusanori Nishimura, Hideki Katagiri, Shin-ichiro Takahashi, Hiroki Kurihara, Takafumi Uchida, Tomoichiro Asano

J Biol Chem. 2012 Dec 28; 287(53): 44526–44535. Published online 2012 Oct 29. doi: 10.1074/jbc.M112.397133

PMCID:: PMC3531766

Abstract Article PDF–3.0M

Microbiology

Mycobacterium tuberculosis ESAT-6 Exhibits a Unique Membrane-interacting Activity That Is Not Found in Its Ortholog from Non-pathogenic Mycobacterium smegmatis

Joaquin De Leon, Guozhong Jiang, Yue Ma, Eric Rubin, Sarah Fortune, Jianjun Sun

J Biol Chem. 2012 Dec 28; 287(53): 44184–44191. Published online 2012 Nov 13. doi: 10.1074/jbc.M112.420869

PMCID:: PMC3531734

Abstract Article PDF–1.7M

Molecular Bases of Disease

Loss of Timp3 Gene Leads to Abdominal Aortic Aneurysm Formation in Response to Angiotensin II

Ratnadeep Basu, Dong Fan, Vijay Kandalam, Jiwon Lee, Subhash K. Das, Xiuhua Wang, Troy A. Baldwin, Gavin Y. Oudit, Zamaneh Kassiri

J Biol Chem. 2012 Dec 28; 287(53): 44083–44096. Published online 2012 Nov 9. doi: 10.1074/jbc.M112.425652

PMCID:: PMC3531724

Abstract Article PDF–6.0M

Retinoid Binding Properties of Nucleotide Binding Domain 1 of the Stargardt Disease-associated ATP Binding Cassette (ABC) Transporter, ABCA4

Esther E. Biswas-Fiss, Stephanie Affet, Malissa Ha, Subhasis B. Biswas

J Biol Chem. 2012 Dec 28; 287(53): 44097–44107. Published online 2012 Nov 9. doi: 10.1074/jbc.M112.409623

PMCID:: PMC3531725

Abstract Article PDF–3.6M

Cyclosporin A Impairs the Secretion and Activity of ADAMTS13 (A Disintegrin and Metalloprotease with Thrombospondin Type 1 Repeat)

Klilah Hershko, Vijaya L. Simhadri, Adam Blaisdell, Ryan C. Hunt, Jordan Newell, Sandra C. Tseng, Alon Y. Hershko, Jae Won Choi, Zuben E. Sauna, Andrew Wu, Richard J. Bram, Anton A. Komar, Chava Kimchi-Sarfaty

J Biol Chem. 2012 Dec 28; 287(53): 44361–44371. Published online 2012 Nov 9. doi: 10.1074/jbc.M112.383968

PMCID:: PMC3531750

Abstract Article PDF–2.1M

An Advanced Glycation End Product (AGE)-Receptor for AGEs (RAGE) Axis Restores Adipogenic Potential of Senescent Preadipocytes through Modulation of p53 Protein Function

Chih-Yu Chen, Allison Martorano Abell, Yang Soo Moon, Kee-Hong Kim

J Biol Chem. 2012 Dec 28; 287(53): 44498–44507. Published online 2012 Nov 13. doi: 10.1074/jbc.M112.399790

Correction in:: J Biol Chem. 2013 Apr 12; 288(15): 10949.

Correction in:: J Biol Chem. 2014 Apr 18; 289(16): 11570.

PMCID:: PMC3531763

Abstract Article PDF–1.5M

Multiple NF-κB Sites in HIV-1 Subtype C Long Terminal Repeat Confer Superior Magnitude of Transcription and Thereby the Enhanced Viral Predominance

Mahesh Bachu, Swarupa Yalla, Mangaiarkarasi Asokan, Anjali Verma, Ujjwal Neogi, Shilpee Sharma, Rajesh V. Murali, Anil Babu Mukthey, Raghavendra Bhatt, Snehajyoti Chatterjee, Roshan Elizabeth Rajan, Narayana Cheedarla, Venkat S. Yadavalli, Anita Mahadevan, Susarla K. Shankar, Nirmala Rajagopalan, Anita Shet, Shanmugam Saravanan, Pachamuthu Balakrishnan, Suniti Solomon, Madhu Vajpayee, Kadappa Shivappa Satish, Tapas K. Kundu, Kuan-Teh Jeang, Udaykumar Ranga

J Biol Chem. 2012 Dec 28; 287(53): 44714–44735. Published online 2012 Nov 6. doi: 10.1074/jbc.M112.397158

PMCID:: PMC3531786

Abstract Article PDF–3.8M

Molecular Biophysics

Conservation of Flexible Residue Clusters among Structural and Functional Enzyme Homologues

Donald Gagné, Laurie-Anne Charest, Sébastien Morin, Evgenii L. Kovrigin, Nicolas Doucet

J Biol Chem. 2012 Dec 28; 287(53): 44289–44300. Published online 2012 Nov 7. doi: 10.1074/jbc.M112.394866

PMCID:: PMC3531744

Abstract Article PDF–2.8M

Neurobiology

Kinin-B2 Receptor Activity Determines the Differentiation Fate of Neural Stem Cells

Cleber A. Trujillo, Priscilla D. Negraes, Telma T. Schwindt, Claudiana Lameu, Cassiano Carromeu, Alysson R. Muotri, João B. Pesquero, Débora M. Cerqueira, Micheli M. Pillat, Héllio D. N. de Souza, Lauro T. Turaça, José G. Abreu, Henning Ulrich

J Biol Chem. 2012 Dec 28; 287(53): 44046–44061. Published online 2012 Nov 6. doi: 10.1074/jbc.M112.407197

PMCID:: PMC3531721

Abstract Article PDF–5.0M

Rescue of PINK1 Protein Null-specific Mitochondrial Complex IV Deficits by Ginsenoside Re Activation of Nitric Oxide Signaling

Kyung-Hee Kim, Karen Song, Seung-Hee Yoon, Omer Shehzad, Yeong-Shik Kim, Jin H. Son

J Biol Chem. 2012 Dec 28; 287(53): 44109–44120. Published online 2012 Nov 9. doi: 10.1074/jbc.M112.408146

PMCID:: PMC3531727

Abstract Article PDF–2.2M

Identification of Three Residues Essential for 5-Hydroxytryptamine 2A-Metabotropic Glutamate 2 (5-HT_2A·mGlu2) Receptor Heteromerization and Its Psychoactive Behavioral Function

José L. Moreno, Carolina Muguruza, Adrienne Umali, Steven Mortillo, Terrell Holloway, Fuencisla Pilar-Cuéllar, Giuseppe Mocci, Jeremy Seto, Luis F. Callado, Rachael L. Neve, Graeme Milligan, Stuart C. Sealfon, Juan F. López-Giménez, J. Javier Meana, Deanna L. Benson, Javier González-Maeso

J Biol Chem. 2012 Dec 28; 287(53): 44301–44319. Published online 2012 Nov 5. doi: 10.1074/jbc.M112.413161

PMCID:: PMC3531745

Abstract Article PDF–3.3M

Lipid Raft-dependent Endocytosis of Close Homolog of Adhesion Molecule L1 (CHL1) Promotes Neuritogenesis

Nan Tian, Iryna Leshchyns'ka, Jeffrey H. Welch, Witold Diakowski, Hongyuan Yang, Melitta Schachner, Vladimir Sytnyk

J Biol Chem. 2012 Dec 28; 287(53): 44447–44463. Published online 2012 Nov 9. doi: 10.1074/jbc.M112.394973

PMCID:: PMC3531758

Abstract Article PDF–4.8M

Contrasting Effects of α-Synuclein and γ-Synuclein on the Phenotype of Cysteine String Protein α (CSPα) Null Mutant Mice Suggest Distinct Function of these Proteins in Neuronal Synapses

Natalia Ninkina, Owen M. Peters, Natalie Connor-Robson, Olga Lytkina, Essam Sharfeddin, Vladimir L. Buchman

J Biol Chem. 2012 Dec 28; 287(53): 44471–44477. Published online 2012 Nov 5. doi: 10.1074/jbc.M112.422402

PMCID:: PMC3531760

Abstract Article PDF–1021K

Differential Regulation of Amyloid-β Endocytic Trafficking and Lysosomal Degradation by Apolipoprotein E Isoforms

Jie Li, Takahisa Kanekiyo, Mitsuru Shinohara, Yunwu Zhang, Mary Jo LaDu, Huaxi Xu, Guojun Bu

J Biol Chem. 2012 Dec 28; 287(53): 44593–44601. Published online 2012 Nov 6. doi: 10.1074/jbc.M112.420224

PMCID:: PMC3531774

Abstract Article PDF–3.3M

Apolipoprotein E Isoforms Help in the Uptake and Degradation of Amyloid-β in Alzheimer disease ♦: Differential Regulation of Amyloid-β Endocytic Trafficking and Lysosomal Degradation by Apolipoprotein E Isoforms

J Biol Chem. 2012 Dec 28; 287(53): 44602. doi: 10.1074/jbc.P112.420224

PMCID:: PMC3531775

Article PDF–146K

The Specificity Protein Factor Sp1 Mediates Transcriptional Regulation of P2X7 Receptors in the Nervous System

Paula García-Huerta, Miguel Díaz-Hernandez, Esmerilda G. Delicado, María Pimentel-Santillana, Mª Teresa Miras-Portugal, Rosa Gómez-Villafuertes

J Biol Chem. 2012 Dec 28; 287(53): 44628–44644. Published online 2012 Nov 8. doi: 10.1074/jbc.M112.390971

PMCID:: PMC3531778

Abstract Article PDF–6.2M

Peptide Derived from HIV-1 TAT Protein Destabilizes a Monolayer of Endothelial Cells in an in Vitro Model of the Blood-Brain Barrier and Allows Permeation of High Molecular Weight Proteins

Itzik Cooper, Keren Sasson, Vivian I. Teichberg, Michal Schnaider-Beeri, Mati Fridkin, Yoram Shechter

J Biol Chem. 2012 Dec 28; 287(53): 44676–44683. Published online 2012 Nov 13. doi: 10.1074/jbc.M112.395384

PMCID:: PMC3531782

Abstract Article PDF–1.0M

Plant Biology

A Na⁺/Ca²⁺ Exchanger-like Protein (AtNCL) Involved in Salt Stress in Arabidopsis

Peng Wang, Zhaowei Li, Jingshuang Wei, Zenglin Zhao, Daye Sun, Sujuan Cui

J Biol Chem. 2012 Dec 28; 287(53): 44062–44070. Published online 2012 Nov 12. doi: 10.1074/jbc.M112.351643

PMCID:: PMC3531722

Abstract Article PDF–2.5M

Protein Structure and Folding

Cysteine Cross-linking Defines the Extracellular Gate for the Leishmania donovani Nucleoside Transporter 1.1 (LdNT1.1)

Raquel Valdés, Ujwal Shinde, Scott M. Landfear

J Biol Chem. 2012 Dec 28; 287(53): 44036–44045. Published online 2012 Nov 13. doi: 10.1074/jbc.M112.414433

PMCID:: PMC3531720

Abstract Article PDF–1.2M

Hepatitis C Virus NS5B and Host Cyclophilin A Share a Common Binding Site on NS5A

Claire Rosnoblet, Bernd Fritzinger, Dominique Legrand, Hélène Launay, Jean-Michel Wieruszeski, Guy Lippens, Xavier Hanoulle

J Biol Chem. 2012 Dec 28; 287(53): 44249–44260. Published online 2012 Nov 14. doi: 10.1074/jbc.M112.392209

PMCID:: PMC3531740

Abstract Article PDF–3.5M

The Size and Conservation of a Coiled-coil Structure in the Ectodomain of Human BST-2/Tetherin Is Dispensable for Inhibition of HIV-1 Virion Release

Amy J. Andrew, Christopher E. Berndsen, Sandra Kao, Klaus Strebel

J Biol Chem. 2012 Dec 28; 287(53): 44278–44288. Published online 2012 Nov 14. doi: 10.1074/jbc.M112.418822

PMCID:: PMC3531743

Abstract Article PDF–2.1M

Evaluating Drosophila p53 as a Model System for Studying Cancer Mutations

Gal Herzog, Andreas C. Joerger, Merav D. Shmueli, Alan R. Fersht, Ehud Gazit, Daniel Segal

J Biol Chem. 2012 Dec 28; 287(53): 44330–44337. Published online 2012 Nov 7. doi: 10.1074/jbc.M112.417980

PMCID:: PMC3531747

Abstract Article PDF–1.4M

Crystal Structure of Reduced MsAcg, a Putative Nitroreductase from Mycobacterium smegmatis and a Close Homologue of Mycobacterium tuberculosis Acg

François-Xavier Chauviac, Martin Bommer, Jun Yan, Gary Parkin, Tina Daviter, Philip Lowden, Emma L. Raven, Konstantinos Thalassinos, Nicholas H. Keep

J Biol Chem. 2012 Dec 28; 287(53): 44372–44383. Published online 2012 Nov 12. doi: 10.1074/jbc.M112.406264

PMCID:: PMC3531751

Abstract Article PDF–3.4M

Novel Clostridium thermocellum Type I Cohesin-Dockerin Complexes Reveal a Single Binding Mode

Joana L. A. Brás, Victor D. Alves, Ana Luísa Carvalho, Shabir Najmudin, José A. M. Prates, Luís M. A. Ferreira, David N. Bolam, Maria João Romão, Harry J. Gilbert, Carlos M. G. A. Fontes

J Biol Chem. 2012 Dec 28; 287(53): 44394–44405. Published online 2012 Nov 1. doi: 10.1074/jbc.M112.407700

PMCID:: PMC3531753

Abstract Article PDF–3.9M

An Ultra-specific Avian Antibody to Phosphorylated Tau Protein Reveals a Unique Mechanism for Phosphoepitope Recognition

Heather H. Shih, Chao Tu, Wei Cao, Anne Klein, Renee Ramsey, Brian J. Fennell, Matthew Lambert, Deirdre Ní Shúilleabháin, Bénédicte Autin, Eugenia Kouranova, Sri Laxmanan, Steven Braithwaite, Leeying Wu, Mostafa Ait-Zahra, Anthony J. Milici, Jo Ann Dumin, Edward R. LaVallie, Maya Arai, Christopher Corcoran, Janet E. Paulsen, Davinder Gill, Orla Cunningham, Joel Bard, Lydia Mosyak, William J. J. Finlay

J Biol Chem. 2012 Dec 28; 287(53): 44425–44434. Published online 2012 Nov 12. doi: 10.1074/jbc.M112.415935

PMCID:: PMC3531756

Abstract Article PDF–1.7M

Hsp33 Controls Elongation Factor-Tu Stability and Allows Escherichia coli Growth in the Absence of the Major DnaK and Trigger Factor Chaperones

Nicolas Bruel, Marie-Pierre Castanié-Cornet, Anne-Marie Cirinesi, Gregory Koningstein, Costa Georgopoulos, Joen Luirink, Pierre Genevaux

J Biol Chem. 2012 Dec 28; 287(53): 44435–44446. Published online 2012 Nov 12. doi: 10.1074/jbc.M112.418525

PMCID:: PMC3531757

Abstract Article PDF–1.4M

Binding of the N-terminal Region of Coactivator TIF2 to the Intrinsically Disordered AF1 Domain of the Glucocorticoid Receptor Is Accompanied by Conformational Reorganizations

Shagufta H. Khan, Smita Awasthi, Chunhua Guo, Devrishi Goswami, Jun Ling, Patrick R. Griffin, S. Stoney Simons, Jr., Raj Kumar

J Biol Chem. 2012 Dec 28; 287(53): 44546–44560. Published online 2012 Nov 6. doi: 10.1074/jbc.M112.411330

PMCID:: PMC3531768

Abstract Article PDF–3.2M

The Structural Basis of Force Generation by the Mitotic Motor Kinesin-5

Adeline Goulet, William M. Behnke-Parks, Charles V. Sindelar, Jennifer Major, Steven S. Rosenfeld, Carolyn A. Moores

J Biol Chem. 2012 Dec 28; 287(53): 44654–44666. Published online 2012 Nov 7. doi: 10.1074/jbc.M112.404228

PMCID:: PMC3531780

Abstract Article PDF–3.0M

The First Structure of Polarity Suppression Protein, Psu from Enterobacteria Phage P4, Reveals a Novel Fold and a Knotted Dimer

Ramanuj Banerjee, Seema Nath, Amitabh Ranjan, Susmita Khamrui, Bibhusita Pani, Ranjan Sen, Udayaditya Sen

J Biol Chem. 2012 Dec 28; 287(53): 44667–44675. Published online 2012 Nov 12. doi: 10.1074/jbc.M112.423202

PMCID:: PMC3531781

Abstract Article PDF–2.5M

Solution Structure of IseA, an Inhibitor Protein of dl-Endopeptidases from Bacillus subtilis, Reveals a Novel Fold with a Characteristic Inhibitory Loop

Ryoichi Arai, Sadaharu Fukui, Naoya Kobayashi, Junichi Sekiguchi

J Biol Chem. 2012 Dec 28; 287(53): 44736–44748. Published online 2012 Oct 22. doi: 10.1074/jbc.M112.414763

PMCID:: PMC3531787

Abstract Article PDF–5.0M

Protein Synthesis and Degradation

The Ubiquitin Ligase Synoviolin Up-regulates Amyloid β Production by Targeting a Negative Regulator of γ-Secretase, Rer1, for Degradation

Chiaki Tanabe, Tomoji Maeda, Kun Zou, Junjun Liu, Shuyu Liu, Toshihiro Nakajima, Hiroto Komano

J Biol Chem. 2012 Dec 28; 287(53): 44203–44211. Published online 2012 Nov 5. doi: 10.1074/jbc.M112.365296

PMCID:: PMC3531736

Abstract Article PDF–2.3M

A Novel SUMO1-specific Interacting Motif in Dipeptidyl Peptidase 9 (DPP9) That Is Important for Enzymatic Regulation

Esther Pilla, Ulrike Möller, Guido Sauer, Francesca Mattiroli, Frauke Melchior, Ruth Geiss-Friedlander

J Biol Chem. 2012 Dec 28; 287(53): 44320–44329. Published online 2012 Nov 14. doi: 10.1074/jbc.M112.397224

PMCID:: PMC3531746

Abstract Article PDF–2.2M

Signal Transduction

Metformin Regulates Glucose Transporter 4 (GLUT4) Translocation through AMP-activated Protein Kinase (AMPK)-mediated Cbl/CAP Signaling in 3T3-L1 Preadipocyte Cells

Jung Ok Lee, Soo Kyung Lee, Ji Hae Kim, Nami Kim, Ga Young You, Ji Wook Moon, Su Jin Kim, Sun Hwa Park, Hyeon Soo Kim

J Biol Chem. 2012 Dec 28; 287(53): 44121–44129. Published online 2012 Nov 7. doi: 10.1074/jbc.M112.361386

PMCID:: PMC3531728

Abstract Article PDF–1.7M

In Vivo Phosphorylation of Ser²¹ and Ser⁸³ during Nutrient-induced Activation of the Yeast Protein Kinase A (PKA) Target Trehalase

Wim Schepers, Griet Van Zeebroeck, Martijn Pinkse, Peter Verhaert, Johan M. Thevelein

J Biol Chem. 2012 Dec 28; 287(53): 44130–44142. Published online 2012 Nov 15. doi: 10.1074/jbc.M112.421503

PMCID:: PMC3531729

Abstract Article PDF–1.7M

Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) and TGFβ-activated Kinase 1 (TAK1) Play Essential Roles in the C-type Lectin Receptor Signaling in Response to Candida albicans Infection

Sara Gorjestani, Bryant G. Darnay, Xin Lin

J Biol Chem. 2012 Dec 28; 287(53): 44143–44150. Published online 2012 Nov 12. doi: 10.1074/jbc.M112.414276

PMCID:: PMC3531730

Abstract Article PDF–1.3M

PAX2 Protein Induces Expression of Cyclin D1 through Activating AP-1 Protein and Promotes Proliferation of Colon Cancer Cells

Hai-Sheng Zhang, Bing Yan, Xue-Bing Li, Li Fan, Yun-Fang Zhang, Guo-Hao Wu, Min Li, Jing Fang

J Biol Chem. 2012 Dec 28; 287(53): 44164–44172. Published online 2012 Nov 7. doi: 10.1074/jbc.M112.401521

PMCID:: PMC3531732

Abstract Article PDF–1.6M

Identification of a Tetrahydroquinoline Analog as a Pharmacological Inhibitor of the cAMP-binding Protein Epac

Delphine Courilleau, Malik Bisserier, Jean-Christophe Jullian, Alexandre Lucas, Pascal Bouyssou, Rodolphe Fischmeister, Jean-Paul Blondeau, Frank Lezoualc'h

J Biol Chem. 2012 Dec 28; 287(53): 44192–44202. Published online 2012 Nov 8. doi: 10.1074/jbc.M112.422956

PMCID:: PMC3531735

Abstract Article PDF–1.6M

Canonical Transient Receptor Potential Channel 2 (TRPC2) as a Major Regulator of Calcium Homeostasis in Rat Thyroid FRTL-5 Cells: IMPORTANCE OF PROTEIN KINASE C δ (PKCδ) AND STROMAL INTERACTION MOLECULE 2 (STIM2)

Pramod Sukumaran, Christoffer Löf, Kati Kemppainen, Pasi Kankaanpää, Ilari Pulli, Johnny Näsman, Tero Viitanen, Kid Törnquist

J Biol Chem. 2012 Dec 28; 287(53): 44345–44360. Published online 2012 Nov 9. doi: 10.1074/jbc.M112.374348

PMCID:: PMC3531749

Abstract Article PDF–3.4M

Additions and Corrections

Bax channel inhibitors prevent mitochondrion-mediated apoptosis and protect neurons in a model of global brain ischemia.

Claudio Hetz, Pierre-Alain Vitte, Agnes Bombrun, Tatiana K. Rostovtseva, Sylvie Montessuit, Agnes Hiver, Matthias K. Schwarz, Dennis J. Church, Stanley J. Korsmeyer, Jean-Claude Martinou, Bruno Antonsson

J Biol Chem. 2012 Dec 28; 287(53): 44108. doi: 10.1074/jbc.A112.505843