doi: 10.1126/science.1107470.
Epub 2005 Jan 27.
Control of excitatory and inhibitory synapse formation by neuroligins
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- PMID: 15681343
- DOI: 10.1126/science.1107470
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Control of excitatory and inhibitory synapse formation by neuroligins
Science.
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Erratum in
- Science. 2005 Jun 3;308(5727):1413
Abstract
The normal function of neural networks depends on a delicate balance between excitatory and inhibitory synaptic inputs. Synapse formation is thought to be regulated by bidirectional signaling between pre- and postsynaptic cells. We demonstrate that members of the Neuroligin family promote postsynaptic differentiation in cultured rat hippocampal neurons. Down-regulation of neuroligin isoform expression by RNA interference results in a loss of excitatory and inhibitory synapses. Electrophysiological analysis revealed a predominant reduction of inhibitory synaptic function. Thus, neuroligins control the formation and functional balance of excitatory and inhibitory synapses in hippocampal neurons.
Comment in
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Neuroscience. Making synapses: a balancing act.Science. 2005 Feb 25;307(5713):1207-8. doi: 10.1126/science.1110011. Science. 2005. PMID: 15731430 No abstract available.
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