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. 2020 Sep 15:315:24-28.
doi: 10.1016/j.ijcard.2020.04.060. Epub 2020 Apr 22.

Left ventricular size and function after percutaneous closure of patent ductus arteriosus in Chinese adults

Zhi Zhan  1 , Lihua Guan  1 , Wenzhi Pan  1 , Xiaochun Zhang  1 , Lei Zhang  1 , Daxin Zhou  2 , Junbo Ge  3
Affiliations

Left ventricular size and function after percutaneous closure of patent ductus arteriosus in Chinese adults

Zhi Zhan et al. Int J Cardiol. .

Abstract

Background: Left ventricular (LV) systolic dysfunction can occur after patent ductus arteriosus (PDA) closure and data in adult Chinese patients are lacking.

Methods: We examined adult Chinese patients who underwent successful transcatheter PDA closure at Zhongshan Hospital. Echocardiographic studies were performed before closure, before discharge, and at 1, 3, 6, and 12 months after closure. A total of 430 patients were included between January 2010 and December 2016. Patients were divided into two groups based on LV end-diastolic diameter (LVEDD): Dilated LV Group: >56 mm (n = 191) and Non-dilated LV Group: ≤56 mm (n = 239).

Results: LVEDD and LV ejection fraction (LVEF) were significantly decreased immediately after closure. Reductions in LVEDD (-10.5% ± 7.1% vs. -4.6% ± 7.0%, P < 0.001) and LVEF (-8.9% ± 12.6% vs. -2.1% ± 8.6%, P < 0.001) were greater in the Dilated LV Group. LV end-systolic diameter (LVESD) remained unchanged compared to levels before closure (-4.0% ± 5.4%, P = 0.257; -2.6% ± 5.4%, P = 0.201). 48 patients in the Dilated LV Group (25.1%) and 7 patients in the Non-dilated LV Group (2.9%) developed late LV systolic dysfunction. In multivariable analysis, LVEF ≥60%, LVEDD <63 mm, and mean pulmonary arterial pressure (mPAP) <29 mmHg were predictive of normal LV function after closure.

Conclusion: Many adult Chinese patients developed early LV dysfunction after PDA closure and some patients developed late LV dysfunction. LVEF, LVEDD, and mPAP were identified as significant predictors of late LV systolic function.

Keywords: Follow-up studies; Left ventricular function; Patent ductus arteriosus; Risk factor.

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Conflict of interest statement

Declaration of competing interest The authors have no conflicts of interest to disclose.

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