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Synthesis
DOI: 10.1055/a-2338-4462
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Asymmetric Total Synthesis of Lobophopyranone A and B

Debendra Mohapatra
1   Organic Synthesis and Process Chemistry, Indian Institute of Chemical Technology CSIR, Hyderabad, India (Ringgold ID: RIN62391)
,
Sudhakar Reddy Guvvala
2   Organic Synthesis and Process Chemistry, Indian Institute of Chemical Technology CSIR, Hyderabad, India (Ringgold ID: RIN62391)
,
Utkal Mani Choudhury
3   Organic Synthesis and Process Chemistry, Indian Institute of Chemical Technology CSIR, Hyderabad, India (Ringgold ID: RIN62391)
,
Sai Keerthana Haritha
4   Organic Synthesis and Process Chemistry, Indian Institute of Chemical Technology CSIR, Hyderabad, India (Ringgold ID: RIN62391)
,
Karamtothu Charan Naik
5   Organic Synthesis and Process Chemistry, Indian Institute of Chemical Technology CSIR, Hyderabad, India (Ringgold ID: RIN62391)
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The first asymmetric total synthesis and structural confirmation of lobophopyranone A and B have been accomplished from commercially available starting materials. Reagent-controlled Keck-Maruoka allylation, Grignard reaction, chelation-controlled Sakurai allylation, and acid-mediated one-step TBS ether deprotection followed by cyclization are the crucial stages in this synthesis that create the 2,6-disubstituted dihydropyranone component.



Publikationsverlauf

Eingereicht: 06. Mai 2024

Angenommen nach Revision: 04. Juni 2024

Accepted Manuscript online:
04. Juni 2024

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