DOI: 10.1055/s-00000131

Synfacts

Issue 07 · Volume 20 · July 2024 DOI: 10.1055/s-014-59791

Synform

A103
Zanda, Matteo: SYNFORM ISSUE 2024/07

Synthesis of Natural Products

z0671
All PDFs of this category
0671
Total Synthesis of (±)-Keramaphidin B and (±)-Ingenamine
0672
Formal Total Synthesis of (±)-Arborisidine
0673
Total Synthesis of (±)-Rhynchine E
0674
Total Synthesis of Nominal Melognine
0675
Total Synthesis of (+)-Randainin D
0676
Total Synthesis of (±)-Pepluacetal
0677
Total Synthesis of (+)-Saxitoxin

Synthesis of Heterocycles

z0679
All PDFs of this category
0679
Asymmetric Hydrogenation of Heteroaromatics Using Brønsted and Lewis Acid Substrate Activation
0680
Copper Catalysis for the Formation of Quaternary Carbon Containing Azepino[4,5-b]indoles
0681
Synthesis of Versatile Pyridinimine Precursors to Access N-Heterocyclic Scaffolds
0682
Base-Promoted Direct C–H Hydroxylation of N-Heteroarenes
0683
‘Flash-Flow’ Generation and Exploitation of 3-Oxetanyllithium as a Reactive Nucleophile
0684
Diaziridinones as an Amine Source for the Synthesis of Fused Indoles
0685
Flow Synthesis of Functionalized 1,2,4-Triazolo[1,5-a]pyridines
0686
Desmethyl SuFEx-IT as a Novel, Stable FSO2 Donor for SuFEx Click Chemistry
0687
Ylide-le Bit of Cycloaddition and Ylide-le Bit of Ring Expansion: Divergent Reactivity of Pyrazolium Ylides
0688
One-Pot Synthesis of 1,2-Diamines
0689
Direct Aryl/Aliphatic Amide Formation through Ring Opening of Non-Activated Aziridines
0690
Synthesis and Reactivity of Housanes and Azahousanes in the Formation of 2-Azanorbornanes

Synthesis of Materials and Unnatural Products

z0691
All PDFs of this category
0691
Polyethylene with Laddered Long-Chain Branching
0692
Ligand-Tuned Open- and Closed-Shell Diborepins
0693
Molecular Cages of Dibenzocyclooctatetraene
0694
A Room-Temperature-Stable, Antiaromatic Cyclopentadienyl Cation
0695
Cyclic Diaryl λ3-Bromanes for Regiodivergent Alkynylation
0696
A Recyclable Polyolefin
0697
Solventless Depolymerization of Nylon-6
0698
Synthesis of carbo-Stilbenes
0699
Tetra- and Dianionic [18]Annulenes
0700
Radical and Cation Reactivity in One Ring
0701
Cyanoketene Anion and Its Reactivity
0702
Torsional Tension-Driven Polymerization

Metals in Synthesis

z0703
All PDFs of this category
0703
Dyotropic Rearrangement of Tertiary Alcohols for the Synthesis of Fluorinated Tetrasubstituted Carbons
0704
Copper-Catalyzed Enantioconvergent C(sp3)–N Cross-Coupling of Aryl Amines and α-Bromo Amides
0705
Iridium-Photocatalyzed Hydrodecyanation of Alkyl Isonitriles with NHC–Borane
0706
Nickel-Catalyzed Divergent Synthesis of Bisboronic Esters
0707
Photoinduced Decarboxylative Aminoalkylation of Vinyl Cyclic Carbonates to Access Stereodefined Olefins
0708
Alkene Dialkylation with Alkyl Halides and Hypervalent Iodine Reagents by Dual Photoredox/Nickel Catalysis
0709
Two-Step Synthesis of 3-Amido-benzo[b]silines via Formal Silyformylation of Ynamides and Friedel-Crafts–Cyclization
0710
Cobalt-Catalyzed Regiodivergent and Asymmetric Reductive Coupling of 1,3-Dienes with Aldehydes
0711
Enantioselective Coupling of Aldehydes with C=O and C=N Bonds via Photoredox-Coupled Cobalt Catalysis
0712
Synthesis of Chiral Naphthalene Isosteres via Copper-Catalyzed Hydroboration
0713
Photocatalytic Aminoalkylation of Alkenes via a Brook Rearrangement Provides Access to γ-Amino Alcohols
0714
Directed C–H Alkylation of Heterobiaryls via Iridium Catalysis
0715
Enantioconvergent C(sp3)–C(sp) Cross-Electrophile Coupling Enabled by Halogen Atom Transfer
0716
Manganese(I)-Catalyzed C(sp3)–H Bond Functionalization of 8-Methylquinolines
0717
Nickel-Catalyzed Reductive Methylation of Secondary Mesylates with Methyl Tosylate
0718
Synthesis of Polysubstituted Vinylsilanes via anti-Selective Carbosilylation of Alkynes
0719
Asymmetric α-Alkylation of β-Ketocarbonyls by Photoredox-Iron-Chiral Primary Amine Triple Catalysis
0720
Ru/Photocatalyzed Decarboxylative Coupling of α-Fluoroacrylic Acids with Difluoroalkyl Bromides
0721
Photo-Induced Copper-Catalyzed C–H Arylation of 1,3-Azoles
0722
Enantioselective Palladium-Catalyzed Synthesis of Polyarenes
0723
Rhodium-Catalyzed Synthesis of Phenanthrenes from Biarylboronic Acids and Sulfoxonium or Iodonium Ylides
0724
Nickel-Catalyzed Asymmetric Hydroalkylation of Alkenyl Fluorides
0725
Direct Allylic C–H Amination of Alkenes with Amines to Branched Allylic Amines under Dual Catalysis
0726
Turning Alkyl Iodides into Acyl Fluorides by Photoinduced Copper-Catalyzed Fluorocarbonylation
0727
Pd(II)-Promoted Addition of Organometallic Reagents to Olefins: Pd-Catalyzed C–C Bond-Forming Reactions
0728
2,5-Hydrofunctionalization of Allene-Ynes

Polymer-Supported Synthesis

z0729
All PDFs of this category
0729
Amination of Aryl Chlorides via Benzynes Catalyzed by Sodium Alkoxide Clusters
0730
Synthesis of Thioxoimidazolidinones Bearing 4-Indolyl/Indenyl Substituents in Water
0731
Continuous-Flow Asymmetric Hydrogenation Using a Silica-PS-Supported Homochiral Iridium Catalyst
0732
Dehydrogenation of α-Cyclohexene-Substituted Nitriles to Benzyl Cyanides
0733
C–H Annulation of Benzoic Acids and Alkynes Using Rh (III) Complex Immobilized onto COF-316
0734
Controlled Hydrogenation of Nitroarenes to Bisaryldiazene Oxides with Single Atomic Co on Nb2O5
0735
Chemoselective Carbene Insertion of N−H Bond Using a Single-Atom Rhodium Catalyst
0736
An Anthraquinone-Based COF: A Direct Hydrogen-Atom Transfer Photocatalyst for C–N/C–C Couplings
0737
Sulfur-Tolerant Reductive Amination by Ruthenium Phosphide Nanoparticles Supported on Carbon
0738
Borylation of Aryl Halides Using a Nickel-Based MOF

Organo- and Biocatalysis

z0739
All PDFs of this category
0739
Photocatalysis Enables the Hydroamidation of Alkenes Using Sulfonyl Azides and Hantzsch Esters
0740
Photocatalyst Enables the Phosphonylation of Unactivated C(sp3)–H Bonds
0741
Brønsted Acid Catalyzes Intramolecular Allylic Substitution Reaction of Allylic Alcohols
0742
Organocatalytic Asymmetric Construction of Vicinal Stereocenters via α-Alkylation
0743
Decarboxylative Sulfhydrylation of Carboxylic Acids Enabled by Multimodal Acridine Photocatalysis
0744
N-Heterocyclic Carbenes Catalyze the Formation of Fused 6-5-5 Tricyclic Natural-Product Frameworks
0745
Enantioselective Access to β,β-Difluorinated Carbocycles
0746
Stereodivergent Radical Cyclizations Enabled by Directed Evolution of Fatty Acid Photodecarboxylases
0747
Hydrodeamination through in situ Generation of Diazonium Species by ortho-Naphthoquinone Catalysis
0748
Organocatalytic Stereodivergent Intramolecular Synthesis of Spiroaminals
0749
Asymmetric Photoredox Catalytic de Mayo Reaction

Innovative Drug Discovery and Development

z0751
All PDFs of this category
0751
Using Artificial Intelligence to Identify TRAF2- and NCK-Interacting Kinase as a Target for Fibrosis
0752
Late-Stage Aromatic-Ring Reduction within Drug Molecules
0753
Mastering Cell Penetration: Wash-Free Fluorogenic Probes for Membrane Damage
0754
An 8 Step Total Synthesis of Tabernanthine and Ibogaline
0755
Late-Stage Diversification of Phenol Containing Compounds via para- to meta-Isomerization
0756
Ligand-Controlled Divergent Coupling with Cobalt Catalysis
0757
A Copper Metallaphotoredox-Catalyzed Dehydroxylative Radical Approach to N-Glycosylation
0758
Synthesis of Ferulic Acid Derivatives Uncovers Potential Candidate for Alzheimer’s Disease Management
0759
TNG908, a Clinical Candidate for PRMT5 Inhibition Exploiting Synthetic Lethality with MTAP
0760
LXRβ-Selective Tricyclic Agonist Developed with New [4σ+4π] and [4σ+4π–1] Cycloaddition Strategy
0761
Discovery of a Potent and Long-Acting Seretonin 5-HT2 Receptor Agonist
0762
Substrate-Induced Regioselectivity in Intermolecular [2+2+2] Cyclotrimerizations
0763
Mechanistic Studies and Reaction Calorimetry Enable Safe Scale-up of a Reduction with NaBH4 and TFA
0764
Ester Synthesis from Methyl Ketones
0765
A Classic Route to the Synthesis of Tamiflu®

Peptide Chemistry

z0767
All PDFs of this category
0767
Utilizing Proline Surrogates in the Synthesis of ‘Difficult’ Peptides
0768
Photoredox-Catalyzed C–H Decyanative Pyridination of N-Arylated Glycine Derivatives with Cyanopyridines
0769
Photoredox-Catalyzed C–H Alkylation of N-Arylated Glycine Derivatives
0770
Synergistic Pd/Cu Catalysis for the Synthesis of Unnatural Quaternary Amino Acids
0771
Deoxyfluorinated Amidation of Carboxylic Acids Using Pyridinesulfonyl Fluoride
0772
The Peptide Backbone-Targeted Installation of (4H)-Imidazolone cis-Amide Bioisosteres Synthetic Strategy
0773
Deprotection of Fmoc Group Using Catalytic Amounts of DMAP under Solvent-Free Conditions
0774
[2,3]-Sigmatropic Rearrangement for the Synthesis of Unnatural α,α-Disubstituted α-Amino Acid Derivatives
0775
Dual Metal-Catalyzed Electrocatalytic Synthesis of Unnatural Amino Acids
0776
AlCl3- and HFIP-Mediated Selective Deprotection of the N-Cbz Group
0777
Ir-Catalyzed Synthesis of β-Substituted α-Amino Acids Using Alkene and Glycine Derivatives
0778
Distal Amino Acids Formation by Amidation of Cyclic Ketones
0779
Efficient Method for the Synthesis of N-Methylated Peptides
0780
Synthesis of Amino Acids with Axially Chiral Diaryl Ethers Units

Flow Chemistry

z0781
All PDFs of this category
0781
Oxidative Asymmetric Catalysis via Microfluidic Flow Electrochemistry
0782
Scalable Synthesis of Glycerol Carbonate Using Serially Connected Mesofluidic-Plate Reactors