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Synlett 1995; 1995(4): 315-316
DOI: 10.1055/s-1995-4969
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A Simple and Practical Synthesis of 1-β-Methylcarbapenems Based on the Counterattack Strategy

Masahiko Seki, Kazuhiko Kondo* , Tameo Iwasaki
  • *Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co. Ltd., 16-89, Kashima-3-chome, Yodogawa-ku, Osaka 532, Japan
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Publication Date:
31 December 2000 (online)

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A convenient synthesis of 1-β-methylcarbapenems from thioesters via chlorotrimethylsilane mediated Dieckmann-type cyclization followed by counterattack of thiolate anion is described.

1-β-methylcarbapenem - counterattack reagent - Dieckmann-type cyclization

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